{"id":"https://openalex.org/W2092580992","doi":"https://doi.org/10.1111/j.1939-1676.2009.0436.x","title":"Von Willebrand Factor Antigen Concentration in Dogs with Sepsis","display_name":"Von Willebrand Factor Antigen Concentration in Dogs with Sepsis","publication_year":2009,"publication_date":"2009-11-30","ids":{"openalex":"https://openalex.org/W2092580992","doi":"https://doi.org/10.1111/j.1939-1676.2009.0436.x","mag":"2092580992","pmid":"https://pubmed.ncbi.nlm.nih.gov/20002549"},"language":"en","primary_location":{"id":"doi:10.1111/j.1939-1676.2009.0436.x","doi":"https://doi.org/10.1111/j.1939-1676.2009.0436.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2009.0436.x","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C.L. Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.L. Rogers","raw_affiliation_strings":["Cummings School of Veterinary Medicine, Tufts University Department of Clinical Sciences, , North Grafton, MA","Department of Clinical Sciences , Cummings School of Veterinary Medicine, Tufts University , North Grafton , MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cummings School of Veterinary Medicine, Tufts University Department of Clinical Sciences, , North Grafton, MA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Clinical Sciences , Cummings School of Veterinary Medicine, Tufts University , North Grafton , MA , USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034681155","display_name":"Elizabeth A. Rozanski","orcid":"https://orcid.org/0000-0003-3233-8930","observed_orcids":["https://orcid.org/0000-0003-3233-8930"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.A. Rozanski","raw_affiliation_strings":["Cummings School of Veterinary Medicine, Tufts University Department of Clinical Sciences, , North Grafton, MA","Department of Clinical Sciences; Cummings School of Veterinary Medicine; Tufts University; North Grafton; MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cummings School of Veterinary Medicine, Tufts University Department of Clinical Sciences, , North Grafton, MA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Clinical Sciences; Cummings School of Veterinary Medicine; Tufts University; North Grafton; MA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":1.1183,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80599869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"1","first_page":"229","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-viii-related-antigen","display_name":"factor VIII-related antigen","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.9800000190734863},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"systemic inflammatory response syndrome","score":0.8600000143051147},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.8040000200271606},{"id":"https://openalex.org/keywords/critically-ill-dogs","display_name":"critically ill dogs","score":0.6850000023841858},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9104456305503845},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8312424421310425},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.7406833171844482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.580828070640564},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5604669451713562},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5421522259712219},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.5248422622680664},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.4924651086330414},{"id":"https://openalex.org/C2778780528","wikidata":"https://www.wikidata.org/wiki/Q709360","display_name":"Von Willebrand disease","level":4,"score":0.48243531584739685},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43049758672714233},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.1736384928226471},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.08869454264640808}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1939-1676.2009.0436.x","doi":"https://doi.org/10.1111/j.1939-1676.2009.0436.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2009.0436.x","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"pmid:20002549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20002549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5400000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1971381181","https://openalex.org/W1972367583","https://openalex.org/W2001291333","https://openalex.org/W2023845758","https://openalex.org/W2024628754","https://openalex.org/W2036827293","https://openalex.org/W2066057720","https://openalex.org/W2132883542","https://openalex.org/W2159826091","https://openalex.org/W2172128074","https://openalex.org/W2408854760","https://openalex.org/W2409259950"],"related_works":["https://openalex.org/W4384200549","https://openalex.org/W2363736606","https://openalex.org/W2021696851","https://openalex.org/W2906019820","https://openalex.org/W2001291333","https://openalex.org/W2911729821","https://openalex.org/W7161285750","https://openalex.org/W4415430118","https://openalex.org/W3199100302","https://openalex.org/W1972954219"],"abstract_inverted_index":{"BACKGROUND:":[0],"Von":[1],"Willebrand":[2,104],"factor":[3],"(vWF)":[4],"antigen":[5,32,123,167,202],"concentration,":[6],"a":[7,84,99,107,111,144,199],"marker":[8],"of":[9,28,55,70,86,102,110,121,204,242],"endothelial":[10,238,243],"activation,":[11],"is":[12,24,230,245],"increased":[13,231],"in":[14,37,169,208,217,232,247],"human":[15],"patients":[16],"with":[17,39,45,58,83,143,158,171,198,234],"multiorgan":[18],"failure,":[19],"sepsis,":[20,235],"or":[21,52,106],"both,":[22],"and":[23,160,196,213],"an":[25],"independent":[26],"predictor":[27],"survival.":[29],"HYPOTHESIS/OBJECTIVES:":[30],"vWF":[31,122,166,201,229],"concentrations":[33],"are":[34],"significantly":[35,179],"higher":[36,180],"dogs":[38,43,64,131,153,157,170,183,233],"sepsis.":[40,46],"ANIMALS:":[41],"Fourteen":[42],"hospitalized":[44],"Sepsis":[47],"was":[48,173,178,191],"defined":[49],"as":[50],"microbiologic":[51],"cytologic":[53],"evidence":[54,69],"infection":[56],"combined":[57],"systemic":[59],"inflammatory":[60],"response":[61],"syndrome.":[62],"Control":[63],"were":[65,88,117,128,137,154],"healthy":[66,182],"dogs,":[67],"without":[68],"disease.":[71],"METHODS:":[72],"Prospective,":[73],"observational":[74],"study.":[75,95],"Dogs":[76],"admitted":[77],"to":[78],"the":[79,94],"intensive":[80],"care":[81],"unit":[82],"diagnosis":[85,101],"sepsis":[87,159,172],"considered":[89,149],"eligible":[90],"for":[91,119],"enrollment":[92],"into":[93],"Exclusion":[96],"criteria":[97],"included":[98],"previous":[100],"von":[103],"disease":[105],"recent":[108],"history":[109],"plasma":[112,115],"transfusion.":[113],"Citrated":[114],"samples":[116,127],"collected":[118],"analysis":[120,142],"by":[124],"ELISA.":[125],"All":[126],"drawn":[129],"from":[130],"during":[132],"hospitalization.":[133],"Data":[134],"between":[135,194],"populations":[136],"analyzed":[138],"using":[139],"nonparametric":[140],"statistical":[141],"P":[145,187],"value":[146],"<":[147,188],".05":[148],"significant.":[150],"RESULTS:":[151],"Twenty-five":[152],"enrolled;":[155],"14":[156],"11":[161],"control":[162],"dogs.":[163,250],"The":[164],"median":[165,200],"concentration":[168,203],"156%":[174],"(range,":[175,206,215],"117-200%),":[176],"which":[177],"than":[181],"(105%;":[184],"range,":[185],"44-155%,":[186],".005).":[189],"There":[190],"no":[192],"difference":[193],"survivors":[195,209],"nonsurvivors":[197,218],"144%":[205],"136-201%)":[207],"(n":[210,219],"=":[211,220,223],"7)":[212,221],"159%":[214],"122-174%)":[216],"(P":[222],".5).":[224],"CONCLUSIONS":[225],"AND":[226],"CLINICAL":[227],"IMPORTANCE:":[228],"possibly":[236],"reflecting":[237],"activation.":[239],"Further":[240],"exploration":[241],"function":[244],"warranted":[246],"critically":[248],"ill":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}