{"id":"https://openalex.org/W2092575408","doi":"https://doi.org/10.1021/ja107716r","title":"A Conserved Helical Capping Hydrogen Bond in PAS Domains Controls Signaling Kinetics in the Superfamily Prototype Photoactive Yellow Protein","display_name":"A Conserved Helical Capping Hydrogen Bond in PAS Domains Controls Signaling Kinetics in the Superfamily Prototype Photoactive Yellow Protein","publication_year":2010,"publication_date":"2010-10-18","ids":{"openalex":"https://openalex.org/W2092575408","doi":"https://doi.org/10.1021/ja107716r","mag":"2092575408","pmid":"https://pubmed.ncbi.nlm.nih.gov/20954744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2999845"},"language":"en","primary_location":{"id":"doi:10.1021/ja107716r","doi":"https://doi.org/10.1021/ja107716r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja107716r","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2999845","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021936299","display_name":"Masato Kumauchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masato Kumauchi","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098972963","display_name":"Sandip Kaledhonkar","orcid":"https://orcid.org/0000-0003-3264-9878","observed_orcids":["https://orcid.org/0000-0003-3264-9878"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandip Kaledhonkar","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016875068","display_name":"Andrew F. Philip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew F. Philip","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076692013","display_name":"James Wycoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Wycoff","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008013104","display_name":"Miwa Hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miwa Hara","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081310614","display_name":"Yunxing Li","orcid":"https://orcid.org/0000-0001-8532-2006","observed_orcids":["https://orcid.org/0000-0001-8532-2006"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunxing Li","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522622","display_name":"Aihua Xie","orcid":"https://orcid.org/0000-0003-2198-3475","observed_orcids":["https://orcid.org/0000-0003-2198-3475"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aihua Xie","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022013143","display_name":"Wouter D. Hoff","orcid":"https://orcid.org/0009-0004-7523-6576","observed_orcids":["https://orcid.org/0009-0004-7523-6576"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wouter D. Hoff","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, and Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078, United States, and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022013143","https://openalex.org/A5113522622"],"corresponding_institution_ids":["https://openalex.org/I115475287","https://openalex.org/I40347166"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6454,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63188746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"132","issue":"44","first_page":"15820","last_page":"15830"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photoactive-yellow-protein","display_name":"photoactive yellow protein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pas-domain","display_name":"PAS domain","score":0.9470000267028809},{"id":"https://openalex.org/keywords/signaling-kinetics","display_name":"signaling kinetics","score":0.6190000176429749},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.765999972820282},{"id":"https://openalex.org/keywords/light-induced-conformational-change","display_name":"light-induced conformational change","score":0.7179999947547913},{"id":"https://openalex.org/keywords/protein-superfamilies","display_name":"protein superfamilies","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8676463961601257},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.752777099609375},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.723943829536438},{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.6372323036193848},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.5346217751502991},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5270158052444458},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5157151818275452},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.42126139998435974},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.4169881343841553},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40550071001052856},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.39412808418273926},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3604661822319031},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.2895878553390503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25014692544937134},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.18690967559814453},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18168479204177856},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.1729261875152588},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06831395626068115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020283","descriptor_name":"Photoreceptors, Microbial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020283","descriptor_name":"Photoreceptors, Microbial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/ja107716r","doi":"https://doi.org/10.1021/ja107716r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja107716r","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:20954744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20954744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2999845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2999845","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2999845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2999845","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6450772672","display_name":"Partial Protein Unfolding as a Novel Signaling Mechanism","funder_award_id":"R01GM063805","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8614963287","display_name":null,"funder_award_id":"GM063805","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W1510749468","https://openalex.org/W1522866871","https://openalex.org/W1542384182","https://openalex.org/W1846561288","https://openalex.org/W1965076207","https://openalex.org/W1965081811","https://openalex.org/W1966024216","https://openalex.org/W1966466027","https://openalex.org/W1972230965","https://openalex.org/W1972284104","https://openalex.org/W1975961825","https://openalex.org/W1977354533","https://openalex.org/W1977922733","https://openalex.org/W1977922844","https://openalex.org/W1981057565","https://openalex.org/W1989190536","https://openalex.org/W1989730765","https://openalex.org/W1991696056","https://openalex.org/W1997220351","https://openalex.org/W1999383152","https://openalex.org/W2003997263","https://openalex.org/W2005474992","https://openalex.org/W2011972818","https://openalex.org/W2012818715","https://openalex.org/W2032281578","https://openalex.org/W2034822725","https://openalex.org/W2035453130","https://openalex.org/W2039744253","https://openalex.org/W2041459336","https://openalex.org/W2041903706","https://openalex.org/W2043046243","https://openalex.org/W2047100044","https://openalex.org/W2050922096","https://openalex.org/W2051046066","https://openalex.org/W2051178356","https://openalex.org/W2052453642","https://openalex.org/W2053430992","https://openalex.org/W2054170338","https://openalex.org/W2055414610","https://openalex.org/W2057517712","https://openalex.org/W2062395162","https://openalex.org/W2066997208","https://openalex.org/W2068704151","https://openalex.org/W2073745636","https://openalex.org/W2081823517","https://openalex.org/W2089206424","https://openalex.org/W2091010896","https://openalex.org/W2091664813","https://openalex.org/W2092002806","https://openalex.org/W2093379270","https://openalex.org/W2098666958","https://openalex.org/W2101439900","https://openalex.org/W2101775543","https://openalex.org/W2105869636","https://openalex.org/W2113113901","https://openalex.org/W2115155685","https://openalex.org/W2118668178","https://openalex.org/W2118728369","https://openalex.org/W2120063605","https://openalex.org/W2122023734","https://openalex.org/W2122178630","https://openalex.org/W2124041817","https://openalex.org/W2124228015","https://openalex.org/W2127960367","https://openalex.org/W2129080549","https://openalex.org/W2133076404","https://openalex.org/W2134059200","https://openalex.org/W2134633181","https://openalex.org/W2137955461","https://openalex.org/W2140951337","https://openalex.org/W2141885858","https://openalex.org/W2142583555","https://openalex.org/W2143332241","https://openalex.org/W2144548299","https://openalex.org/W2145502155","https://openalex.org/W2151304736","https://openalex.org/W2159426997","https://openalex.org/W2163138292","https://openalex.org/W2165588176","https://openalex.org/W2172063092","https://openalex.org/W3047703793","https://openalex.org/W4210400672"],"related_works":["https://openalex.org/W2520873411","https://openalex.org/W2167875436","https://openalex.org/W2019573907","https://openalex.org/W2563402084","https://openalex.org/W2032281578","https://openalex.org/W2087191747","https://openalex.org/W2047100044","https://openalex.org/W2015840296","https://openalex.org/W2046646354","https://openalex.org/W2001322788"],"abstract_inverted_index":{"PAS":[0,35,82,223,252],"domains":[1,26,224],"form":[2],"a":[3,15,81,107,126,132],"divergent":[4],"protein":[5,79,129,172,177],"superfamily":[6],"with":[7,37],"more":[8],"than":[9],"20":[10],"000":[11],"members":[12],"that":[13,205,226,243],"perform":[14],"wide":[16],"array":[17],"of":[18,27,44,54,93,96,117,138,142,148,161,168,192,213,217,222,231],"sensing":[19],"and":[20,64,67,87,112,131,241],"regulatory":[21],"functions":[22,53],"in":[23,34,74,121,128,135,151,187,250],"all":[24],"three":[25],"life.":[28],"Only":[29],"nine":[30,56],"residues":[31,58],"are":[32,59],"well-conserved":[33],"domains,":[36],"an":[38,91],"Asn":[39],"residue":[40,232,236],"at":[41,100],"the":[42,48,75,94,118,136,139,157,165,227],"start":[43],"\u03b1-helix":[45],"3":[46],"showing":[47],"strongest":[49],"conservation.":[50],"The":[51,85,104],"molecular":[52],"these":[55],"conserved":[57,102,240],"unknown.":[60],"We":[61],"use":[62],"static":[63],"time-resolved":[65],"visible":[66,109],"FTIR":[68,202],"spectroscopy":[69,203],"to":[70,156,174],"investigate":[71],"receptor":[72],"activation":[73,183],"photosensor":[76],"photoactive":[77],"yellow":[78],"(PYP),":[80],"domain":[83],"prototype.":[84],"N43A":[86,122],"N43S":[88],"mutants":[89,105,208],"allow":[90],"investigation":[92],"role":[95],"side-chain":[97,189,228],"hydrogen":[98,119,190,229],"bonding":[99,191,230],"this":[101,143,149],"position.":[103],"exhibit":[106],"blue-shifted":[108],"absorbance":[110],"maximum":[111],"up-shifted":[113],"chromophore":[114],"pK(a).":[115],"Disruption":[116],"bonds":[120],"PYP":[123,182],"causes":[124],"both":[125,206],"reduction":[127],"stability":[130],"3400-fold":[133],"increase":[134,150],"lifetime":[137,152],"signaling":[140,248],"state":[141],"photoreceptor.":[144],"A":[145,179],"significant":[146],"part":[147],"can":[153],"be":[154],"attributed":[155],"helical":[158,169,245],"capping":[159,170],"interaction":[160],"Asn43.":[162],"This":[163],"extends":[164],"known":[166],"importance":[167],"for":[171,181,196],"structure":[173],"regulating":[175],"functional":[176],"kinetics.":[178],"model":[180],"has":[184],"been":[185],"proposed":[186],"which":[188],"Asn43":[193,207],"is":[194,238],"critical":[195],"relaying":[197],"light-induced":[198],"conformational":[199],"changes.":[200,215],"However,":[201],"shows":[204],"retain":[209],"full":[210],"allosteric":[211],"transmission":[212],"structural":[214],"Analysis":[216],"30":[218],"available":[219],"high-resolution":[220],"structures":[221],"reveals":[225],"43":[233],"but":[234],"not":[235],"identity":[237],"highly":[239],"suggests":[242],"its":[244],"cap":[246],"affects":[247],"kinetics":[249],"other":[251],"domains.":[253]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
