{"id":"https://openalex.org/W2092459014","doi":"https://doi.org/10.1159/000314367","title":"Increased Adverse Drug Reactions to Cephalosporins in Penicillin Allergy Patients with Positive Penicillin Skin Test","display_name":"Increased Adverse Drug Reactions to Cephalosporins in Penicillin Allergy Patients with Positive Penicillin Skin Test","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2092459014","doi":"https://doi.org/10.1159/000314367","mag":"2092459014","pmid":"https://pubmed.ncbi.nlm.nih.gov/20484925"},"language":"en","primary_location":{"id":"doi:10.1159/000314367","doi":"https://doi.org/10.1159/000314367","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000314367","pdf_url":null,"source":{"id":"https://openalex.org/S205866209","display_name":"International Archives of Allergy and Immunology","issn_l":"1018-2438","issn":["1018-2438","1423-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018912038","display_name":"Miguel A. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel A. Park","raw_affiliation_strings":["Division of Allergic Diseases, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. park.miguel@mayo.edu","Division of Allergic Diseases, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergic Diseases, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. park.miguel@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Allergic Diseases, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082017055","display_name":"Cody A. Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cody A. Koch","raw_affiliation_strings":["Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088393903","display_name":"P.J. Klemawesch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Klemawesch","raw_affiliation_strings":["Tulane University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076514127","display_name":"Avni Y. Joshi","orcid":"https://orcid.org/0000-0002-7877-7261","observed_orcids":["https://orcid.org/0000-0002-7877-7261"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avni Joshi","raw_affiliation_strings":["Mayo Clinic College of Medicine and Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074790677","display_name":"James T. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Li","raw_affiliation_strings":["Mayo Clinic College of Medicine and Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6255,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.88379008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"153","issue":"3","first_page":"268","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cephalosporins","display_name":"cephalosporins","score":0.9179999828338623},{"id":"https://openalex.org/keywords/penicillin-allergy","display_name":"penicillin allergy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8629999756813049},{"id":"https://openalex.org/keywords/penicillin-skin-testing","display_name":"penicillin skin testing","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ige-mediated-hypersensitivity","display_name":"IgE-mediated hypersensitivity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/first-generation-cephalosporins","display_name":"first-generation cephalosporins","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antibiotic-safety","display_name":"antibiotic safety","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.8697662353515625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8340447545051575},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.7656693458557129},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.563073456287384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47273197770118713},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.467612624168396},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4143528342247009},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.39718490839004517},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.34362369775772095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3057876229286194},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.17115965485572815},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000314367","doi":"https://doi.org/10.1159/000314367","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000314367","pdf_url":null,"source":{"id":"https://openalex.org/S205866209","display_name":"International Archives of Allergy and Immunology","issn_l":"1018-2438","issn":["1018-2438","1423-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Immunology","raw_type":"journal-article"},{"id":"pmid:20484925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20484925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International archives of allergy and immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W59590514","https://openalex.org/W1512809158","https://openalex.org/W1566875691","https://openalex.org/W1635988529","https://openalex.org/W1811046990","https://openalex.org/W1987507920","https://openalex.org/W1999836718","https://openalex.org/W2006215766","https://openalex.org/W2017367662","https://openalex.org/W2026582524","https://openalex.org/W2054774286","https://openalex.org/W2062135158","https://openalex.org/W2071423724","https://openalex.org/W2072564715","https://openalex.org/W2073751032","https://openalex.org/W2075032257","https://openalex.org/W2080273768","https://openalex.org/W2085563465","https://openalex.org/W2089908113","https://openalex.org/W2095136329","https://openalex.org/W2098192238","https://openalex.org/W2113806874","https://openalex.org/W2151098717","https://openalex.org/W4243807236","https://openalex.org/W4252498764"],"related_works":["https://openalex.org/W1979470649","https://openalex.org/W1566875691","https://openalex.org/W4240312301","https://openalex.org/W1980207742","https://openalex.org/W2128968496","https://openalex.org/W1965380827","https://openalex.org/W2409170263","https://openalex.org/W2089908113","https://openalex.org/W2080273768","https://openalex.org/W4252498764"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cephalosporin":[1],"administration":[2],"in":[3,20,211],"patients":[4,21,57,77,112,126,212,232],"with":[5,22,58,78,113,127,213,233],"a":[6,23,29,33,79,85,114,128,224,234],"history":[7,24,80,115,129,235],"of":[8,18,25,36,41,50,65,76,81,116,130,143,158,160,169,184,190,203,236],"penicillin":[9,26,42,45,59,82,89,107,117,121,131,135,214,218,237],"allergy":[10,27,43,60,83,118,132],"is":[11,227],"controversial.":[12],"Studies":[13],"looking":[14],"at":[15,62],"the":[16,161,176,179,193],"safety":[17],"cephalosporin":[19,94,105,152,209],"lacked":[28,39],"control":[30],"group,":[31],"had":[32,146],"small":[34],"number":[35],"patients,":[37],"and/or":[38],"confirmation":[40],"by":[44],"skin":[46,90,108,122,136,219],"testing.":[47,109],"The":[48,167],"purpose":[49],"this":[51],"study":[52,75],"was":[53,95,181],"to":[54,104,151,155,175,187,208,228,231],"determine":[55],"whether":[56],"were":[61,98,138],"increased":[63],"risk":[64,202],"adverse":[66,101,148,172,205],"drug":[67,102,149,173,206],"reactions":[68,103,174],"when":[69,92],"administered":[70,93,139,230],"cephalosporin.":[71,140],"METHODS:":[72],"A":[73,200],"cohort":[74],"and":[84,119,124,133],"positive":[86,120],"or":[87],"negative":[88,134],"test":[91,123,137],"conducted.":[96],"Charts":[97],"reviewed":[99],"for":[100],"after":[106],"RESULTS:":[110],"Eighty-five":[111],"726":[125,159,191],"Five":[141],"(6%)":[142],"85":[144,185],"cases":[145,180],"an":[147,204],"reaction":[150,207],"as":[153],"compared":[154,186],"5":[156],"(0.7%)":[157],"referent":[162,194],"population":[163,195],"(p":[164,196],"=":[165,197],"0.0019).":[166],"rate":[168],"presumed":[170],"IgE-mediated":[171],"cephalosporins":[177],"amongst":[178,192],"2":[182],"(2%)":[183],"1":[188],"(0.1%)":[189],"0.0304).":[198],"CONCLUSION:":[199],"greater":[201],"exists":[210],"allergy.":[215,238],"We":[216],"recommend":[217],"testing":[220],"if":[221],"cephalosporin,":[222,226],"especially":[223],"first-generation":[225],"be":[229]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}