{"id":"https://openalex.org/W2092436074","doi":"https://doi.org/10.1158/0008-5472.can-14-1835","title":"Plasma Choline Metabolites and Colorectal Cancer Risk in the Women's Health Initiative Observational Study","display_name":"Plasma Choline Metabolites and Colorectal Cancer Risk in the Women's Health Initiative Observational Study","publication_year":2014,"publication_date":"2014-10-21","ids":{"openalex":"https://openalex.org/W2092436074","doi":"https://doi.org/10.1158/0008-5472.can-14-1835","mag":"2092436074","pmid":"https://pubmed.ncbi.nlm.nih.gov/25336191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4268282"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-14-1835","doi":"https://doi.org/10.1158/0008-5472.can-14-1835","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-1835","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4268282","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085743761","display_name":"Sajin Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sajin Bae","raw_affiliation_strings":["1Division of Nutritional Sciences, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Nutritional Sciences, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016535463","display_name":"Cornelia M. Ulrich","orcid":"https://orcid.org/0000-0001-7641-059X","observed_orcids":["https://orcid.org/0000-0001-7641-059X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Cornelia M. Ulrich","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington","3German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany","4Huntsman Cancer Institute, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"3German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460"]},{"raw_affiliation_string":"4Huntsman Cancer Institute, Salt Lake City, Utah","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037632878","display_name":"Marian L. Neuhouser","orcid":"https://orcid.org/0000-0002-3876-0000","observed_orcids":["https://orcid.org/0000-0002-3876-0000"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian L. Neuhouser","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040098215","display_name":"Olga Malysheva","orcid":"https://orcid.org/0000-0002-8626-5071","observed_orcids":["https://orcid.org/0000-0002-8626-5071"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Malysheva","raw_affiliation_strings":["1Division of Nutritional Sciences, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Nutritional Sciences, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108350069","display_name":"Lynn B. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn B. Bailey","raw_affiliation_strings":["5Department of Foods and Nutrition, University of Georgia, Athens, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Foods and Nutrition, University of Georgia, Athens, Georgia","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112028498","display_name":"Liren Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liren Xiao","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086552148","display_name":"Elissa C. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elissa C. Brown","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023546258","display_name":"Kara L. Cushing\u2010Haugen","orcid":"https://orcid.org/0000-0003-2993-0191","observed_orcids":["https://orcid.org/0000-0003-2993-0191"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara L. Cushing-Haugen","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011932896","display_name":"Yingye Zheng","orcid":"https://orcid.org/0000-0002-3078-4200","observed_orcids":["https://orcid.org/0000-0002-3078-4200"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingye Zheng","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088345646","display_name":"Ting\u2010Yuan David Cheng","orcid":"https://orcid.org/0000-0002-4105-828X","observed_orcids":["https://orcid.org/0000-0002-4105-828X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting-Yuan David Cheng","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040268724","display_name":"Joshua W. Miller","orcid":"https://orcid.org/0000-0002-9126-0224","observed_orcids":["https://orcid.org/0000-0002-9126-0224"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua W. Miller","raw_affiliation_strings":["6Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey","7Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"7Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076155451","display_name":"Ralph Green","orcid":"https://orcid.org/0000-0002-9935-230X","observed_orcids":["https://orcid.org/0000-0002-9935-230X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Green","raw_affiliation_strings":["7Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061079061","display_name":"Dorothy S. Lane","orcid":"https://orcid.org/0000-0003-3272-0451","observed_orcids":["https://orcid.org/0000-0003-3272-0451"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy S. Lane","raw_affiliation_strings":["8Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069321664","display_name":"Shirley A.A. Beresford","orcid":"https://orcid.org/0000-0002-1631-3541","observed_orcids":["https://orcid.org/0000-0002-1631-3541"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirley A.A. Beresford","raw_affiliation_strings":["2Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077583806","display_name":"Marie A. Caudill","orcid":"https://orcid.org/0000-0002-7192-5743","observed_orcids":["https://orcid.org/0000-0002-7192-5743"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marie A. Caudill","raw_affiliation_strings":["1Division of Nutritional Sciences, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Nutritional Sciences, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5016535463","https://openalex.org/A5077583806"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I205783295","https://openalex.org/I2801159745","https://openalex.org/I4210089486","https://openalex.org/I4210111460"],"apc_list":null,"apc_paid":null,"fwci":15.193,"has_fulltext":false,"cited_by_count":253,"citation_normalized_percentile":{"value":0.99398639,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"74","issue":"24","first_page":"7442","last_page":"7452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.3962000012397766,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.3962000012397766,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.07490000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer-risk","display_name":"colorectal cancer risk","score":0.7440000176429749},{"id":"https://openalex.org/keywords/choline-metabolism","display_name":"choline metabolism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/plasma-choline","display_name":"plasma choline","score":0.8220000267028809},{"id":"https://openalex.org/keywords/betaine","display_name":"betaine","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dimethylglycine","display_name":"dimethylglycine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.7979999780654907},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8309999704360962},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.6269999742507935},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.640999972820282},{"id":"https://openalex.org/keywords/women-s-health-initiative-observational-study","display_name":"Women's Health Initiative Observational Study","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.3869999945163727},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.49000000953674316},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.7862679958343506},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6618300080299377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5748355388641357},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5298917889595032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.505511999130249},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.4871194362640381},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4426579177379608},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.36848270893096924}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001622","descriptor_name":"Betaine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016387","descriptor_name":"Women's Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-14-1835","doi":"https://doi.org/10.1158/0008-5472.can-14-1835","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-1835","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:25336191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25336191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4268282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4268282","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7d85t1q2","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7d85t1q2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, vol 74, iss 24","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4268282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4268282","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1947136479","display_name":null,"funder_award_id":"HHSN-271-2011-00004C,","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2273349799","display_name":null,"funder_award_id":"HHSN2682011-00001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2412562481","display_name":null,"funder_award_id":"HHSN2682011-00002I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3545534745","display_name":null,"funder_award_id":"HHSN268201100004C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G412187901","display_name":null,"funder_award_id":"HHSN2682011\u201000004I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4292434131","display_name":"COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE","funder_award_id":"n01wh22110-38-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5222267060","display_name":"A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation","funder_award_id":"R01CA120523","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5547620395","display_name":null,"funder_award_id":"HHSN268201100046C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5624510383","display_name":null,"funder_award_id":"HHSN268201100001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G619791618","display_name":null,"funder_award_id":"HHSN268201100002C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G673128162","display_name":null,"funder_award_id":"HHSN2682011-00003I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8536616440","display_name":null,"funder_award_id":"HHSN268201100003C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000072420","display_name":null,"funder_award_id":"N01 WH022110","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1486422396","https://openalex.org/W1496881867","https://openalex.org/W1566752830","https://openalex.org/W1904131152","https://openalex.org/W1945361080","https://openalex.org/W1964492131","https://openalex.org/W1964820180","https://openalex.org/W1969260540","https://openalex.org/W1995802267","https://openalex.org/W1996944921","https://openalex.org/W1999274023","https://openalex.org/W2005647936","https://openalex.org/W2010868528","https://openalex.org/W2014242281","https://openalex.org/W2018159164","https://openalex.org/W2026515811","https://openalex.org/W2034227377","https://openalex.org/W2039687911","https://openalex.org/W2041997761","https://openalex.org/W2042917569","https://openalex.org/W2047717400","https://openalex.org/W2050253291","https://openalex.org/W2057179832","https://openalex.org/W2078599166","https://openalex.org/W2080748385","https://openalex.org/W2083166156","https://openalex.org/W2086122221","https://openalex.org/W2094232118","https://openalex.org/W2107375724","https://openalex.org/W2107604852","https://openalex.org/W2107663617","https://openalex.org/W2108208362","https://openalex.org/W2115895853","https://openalex.org/W2115944543","https://openalex.org/W2116238178","https://openalex.org/W2117312367","https://openalex.org/W2120914209","https://openalex.org/W2137477400","https://openalex.org/W2139464173","https://openalex.org/W2142877787","https://openalex.org/W2144699481","https://openalex.org/W2146480823","https://openalex.org/W2148525284","https://openalex.org/W2149323323","https://openalex.org/W2157203835","https://openalex.org/W2158110124","https://openalex.org/W2164414963","https://openalex.org/W2167062509","https://openalex.org/W2167395179","https://openalex.org/W2167726756","https://openalex.org/W2223510917","https://openalex.org/W2223740256","https://openalex.org/W2290627980","https://openalex.org/W2480480180","https://openalex.org/W2484555569","https://openalex.org/W4247137469"],"related_works":["https://openalex.org/W7095447914","https://openalex.org/W2123689376","https://openalex.org/W2578584710","https://openalex.org/W4391309300","https://openalex.org/W2038873341","https://openalex.org/W2158110124","https://openalex.org/W2108210899","https://openalex.org/W4368376091","https://openalex.org/W2559403154","https://openalex.org/W2107160040"],"abstract_inverted_index":{"Few":[0],"studies":[1],"have":[2],"examined":[3],"associations":[4,17],"between":[5,18,275],"plasma":[6,19,93,106,133,160,204,239,276],"choline":[7,22,94,107,210,254],"metabolites":[8,95],"and":[9,27,31,56,68,79,148,194,227,278],"risk":[10,34,116,232,268,281],"of":[11,21,87,90,209,269,287],"colorectal":[12,32,139,167,230,270,279,292],"cancer.":[13,271],"Therefore,":[14],"we":[15],"investigated":[16],"biomarkers":[20],"metabolism":[23],"[choline,":[24],"betaine,":[25],"dimethylglycine,":[26],"trimethylamine":[28],"N-oxide":[29],"(TMAO)]":[30],"cancer":[33,74,115,140,168,220,231,280,293],"among":[35,233],"postmenopausal":[36],"women":[37,234],"in":[38,253,260,291],"a":[39],"case-control":[40,54],"study":[41],"nested":[42],"within":[43],"the":[44,85,159,288],"Women's":[45],"Health":[46],"Initiative":[47],"Observational":[48],"Study.":[49],"We":[50],"selected":[51],"835":[52],"matched":[53],"pairs,":[55],"cases":[57],"were":[58,96],"further":[59],"stratified":[60],"by":[61,77,81,98,212],"tumor":[62],"site":[63],"(proximal,":[64],"distal,":[65],"or":[66,71],"rectal)":[67],"stage":[69],"(local/regional":[70],"metastatic).":[72],"Colorectal":[73],"was":[75,135,163,215],"assessed":[76],"self-report":[78],"confirmed":[80],"medical":[82],"records":[83],"over":[84],"mean":[86],"5.2":[88],"years":[89],"follow-up.":[91],"Baseline":[92],"measured":[97],"LC/MS-MS.":[99],"In":[100],"multivariable-adjusted":[101],"conditional":[102],"logistic":[103],"regression":[104],"models,":[105],"tended":[108],"to":[109],"be":[110,264],"positively":[111,216],"associated":[112,137,165,217,265],"with":[113,138,149,166,179,218,228,235,266,284],"rectal":[114,187,219],"[OR":[117],"(95%":[118],"confidence":[119],"interval,":[120],"CI)(highest":[121],"vs.":[122],"lowest":[123],"quartile)":[124],"=":[125,130,146,156,174,185,192,200,225,245],"2.44":[126],"(0.93-6.40);":[127],"P":[128,144,154,172,183,190,198,223],"trend":[129,145,155,173,184,191,199,224],"0.08],":[131],"whereas":[132],"betaine":[134],"inversely":[136,164],"overall":[141,169,229],"[0.68":[142],"(0.47-0.99);":[143],"0.01]":[147],"local/regional":[150,195],"tumors":[151],"[0.64":[152],"(0.42-0.99);":[153],"0.009].":[157],"Notably,":[158],"betaine:choline":[161],"ratio":[162],"[0.56":[170],"(0.39-0.82);":[171],"0.004]":[175],"as":[176,178],"well":[177],"proximal":[180],"[0.66":[181],"(0.41-1.06);":[182],"0.049],":[186],"[0.27":[188],"(0.10-0.78);":[189],"0.02],":[193],"[0.50":[196],"(0.33-0.76);":[197],"0.001]":[201],"tumors.":[202],"Finally,":[203],"TMAO,":[205],"an":[206,285],"oxidative":[207],"derivative":[208],"produced":[211],"intestinal":[213],"bacteria,":[214],"[3.38":[221],"(1.25-9.16);":[222],"0.02]":[226],"lower":[236],"(vs.":[237],"higher)":[238],"vitamin":[240],"B12":[241],"levels":[242],"(P":[243],"interaction":[244],"0.003).":[246],"Collectively,":[247],"these":[248],"data":[249],"suggest":[250],"that":[251],"alterations":[252],"metabolism,":[255],"which":[256],"may":[257,263],"arise":[258],"early":[259],"disease":[261],"development,":[262],"higher":[267],"The":[272],"positive":[273],"association":[274],"TMAO":[277],"is":[282],"consistent":[283],"involvement":[286],"gut":[289],"microbiome":[290],"pathogenesis.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}