{"id":"https://openalex.org/W2092409342","doi":"https://doi.org/10.1210/endo-116-5-1997","title":"Hormone Ontogeny in the Ovine Fetus. XVIII. The Effect of an Opioid Antagonist on Luteinizing Hormone Secretion*","display_name":"Hormone Ontogeny in the Ovine Fetus. XVIII. The Effect of an Opioid Antagonist on Luteinizing Hormone Secretion*","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W2092409342","doi":"https://doi.org/10.1210/endo-116-5-1997","mag":"2092409342","pmid":"https://pubmed.ncbi.nlm.nih.gov/3987627"},"language":"en","primary_location":{"id":"doi:10.1210/endo-116-5-1997","doi":"https://doi.org/10.1210/endo-116-5-1997","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-116-5-1997","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049641886","display_name":"Leona Cuttler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LEONA CUTTLER","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036979069","display_name":"CATHERINE A. EGLI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CATHERINE A. EGLI","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111726316","display_name":"Dennis M. Styne","orcid":"https://orcid.org/0000-0002-9978-5244","observed_orcids":["https://orcid.org/0000-0002-9978-5244"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DENNIS M. STYNE","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108398767","display_name":"Selna L. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SELNA L. KAPLAN","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011827648","display_name":"Melvin M. Grumbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MELVIN M. GRUMBACH","raw_affiliation_strings":["Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.18302055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"116","issue":"5","first_page":"1997","last_page":"2002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/opioid-peptides","display_name":"opioid peptides","score":0.7879999876022339},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9359999895095825},{"id":"https://openalex.org/keywords/opioid-receptor-antagonism","display_name":"opioid antagonism","score":0.7960000038146973},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.854782223701477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.82856285572052},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.712353527545929},{"id":"https://openalex.org/C2775962371","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Opioid antagonist","level":5,"score":0.6919049024581909},{"id":"https://openalex.org/C3017995582","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Endogenous opioid","level":4,"score":0.6840224862098694},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6470678448677063},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6434382200241089},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5649333596229553},{"id":"https://openalex.org/C2908806481","wikidata":"https://www.wikidata.org/wiki/Q282902","display_name":"Naloxone Hydrochloride","level":5,"score":0.5484618544578552},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.5019021034240723},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.49371251463890076},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.47232288122177124},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.4657728374004364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45248889923095703},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37061774730682373},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2915852665901184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25061213970184326},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21558144688606262},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-116-5-1997","doi":"https://doi.org/10.1210/endo-116-5-1997","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-116-5-1997","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:3987627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3987627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1566369689","https://openalex.org/W1965584350","https://openalex.org/W1965657035","https://openalex.org/W1966566725","https://openalex.org/W1967477824","https://openalex.org/W1975832789","https://openalex.org/W1977307719","https://openalex.org/W1979708973","https://openalex.org/W1980539818","https://openalex.org/W1981548597","https://openalex.org/W1984345962","https://openalex.org/W1991989219","https://openalex.org/W1992534222","https://openalex.org/W1993909060","https://openalex.org/W2002109451","https://openalex.org/W2014703688","https://openalex.org/W2018505526","https://openalex.org/W2025218513","https://openalex.org/W2032248898","https://openalex.org/W2041299031","https://openalex.org/W2051303089","https://openalex.org/W2056150879","https://openalex.org/W2057611200","https://openalex.org/W2059215555","https://openalex.org/W2067419173","https://openalex.org/W2067970841","https://openalex.org/W2070292680","https://openalex.org/W2076531996","https://openalex.org/W2077016255","https://openalex.org/W2078916825","https://openalex.org/W2080044517","https://openalex.org/W2082725448","https://openalex.org/W2084413241","https://openalex.org/W2085173273","https://openalex.org/W2087064641","https://openalex.org/W2088860740","https://openalex.org/W2089583628","https://openalex.org/W2094658938","https://openalex.org/W2094804826","https://openalex.org/W2110049096","https://openalex.org/W2116972835","https://openalex.org/W2140225382","https://openalex.org/W2150480376"],"related_works":["https://openalex.org/W2088121632","https://openalex.org/W2080658871","https://openalex.org/W2007545340","https://openalex.org/W1970289054","https://openalex.org/W2083229008","https://openalex.org/W2008093988","https://openalex.org/W2102462083","https://openalex.org/W2015964630","https://openalex.org/W2035397986","https://openalex.org/W1975832789"],"abstract_inverted_index":{"Endogenous":[0],"opioid-like":[1,210],"peptides":[2,16,211],"influence":[3],"gonadotropin":[4],"release":[5,97,236],"in":[6,17,172,205,233,249,262],"adult":[7],"animals":[8],"and":[9,109,149],"man;":[10],"however,":[11],"the":[12,18,61,67,70,75,104,144,206,229,246,250,258,263],"role":[13],"of":[14,20,45,69,77,103,146,164,187,231,271],"these":[15],"regulation":[19],"fetal":[21,265],"LH":[22,79,96,123,173,218,235,266],"secretion":[23,80,124,174,219,267],"is":[24,256,269],"not":[25,99,257],"known.":[26],"We":[27],"administered":[28,114],"naloxone":[29,110,135,148,158,177,232],"hydrochloride":[30],"(1.3":[31,111],"mg/kg":[32],"iv),":[33],"a":[34,55,64,168,213],"specific":[35],"opioid":[36,254],"receptor":[37],"antagonist,":[38],"to":[39,86,116,137,157],"22":[40],"chronically":[41],"catheterized":[42],"ovine":[43,207,251],"fetuses":[44,118,186],"gestational":[46,161,188,240],"ages":[47],"94-143":[48],"days":[49,166,191,226],"(term":[50],"=":[51],"147":[52],"days).":[53],"As":[54],"control,":[56],"each":[57],"fetus":[58,208],"also":[59],"received":[60],"vehicle":[62],"on":[63,217],"separate":[65],"occasion,":[66],"sequence":[68],"studies":[71],"being":[72],"randomized.":[73],"After":[74],"administration":[76,102,145],"naloxone,":[78],"increased":[81],"from":[82,128],"38.6":[83],"+/-":[84,88,130,139,179,193],"5.8":[85],"114":[87],"21":[89],"ng/h":[90,132,141,181,195],"ml-1":[91,133,142],"(P":[92,151,197],"less":[93,152,198],"than":[94,153,183,199],"0.001);":[95],"was":[98,125],"affected":[100],"by":[101],"vehicle.":[105],"Morphine":[106],"(13":[107],"mg/kg)":[108,112],"were":[113],"together":[115],"three":[117],"(gestational":[119],"age":[120,189],"94-105":[121],"days);":[122],"sharply":[126],"reduced":[127],"411":[129],"14.3":[131],"after":[134,143],"alone":[136],"53":[138],"17.5":[140],"both":[147],"morphine":[150],"0.01).":[154],"The":[155],"response":[156],"varied":[159],"with":[160,238],"age.":[162,241],"Fetuses":[163],"94-115":[165],"showed":[167],"significantly":[169],"higher":[170],"increment":[171],"when":[175],"given":[176],"(112.3":[178],"30.7":[180],"ml-1)":[182,196],"did":[184],"older":[185],"126-143":[190],"(64.8":[192],"20.8":[194],"0.02).":[200],"These":[201],"findings":[202],"indicate":[203],"that,":[204,248],"endogenous":[209,253],"exert":[212],"tonic":[214],"suppressive":[215],"effect":[216],"at":[220],"least":[221],"as":[222,224],"early":[223],"94":[225],"gestation.":[227,273],"Moreover,":[228],"effectiveness":[230],"augmenting":[234],"decreases":[237],"advancing":[239],"This":[242],"latter":[243],"observation":[244],"supports":[245],"concept":[247],"fetus,":[252],"tone":[255],"sole":[259],"factor":[260],"involved":[261],"dampened":[264],"which":[268],"characteristic":[270],"late":[272]},"counts_by_year":[{"year":2016,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
