{"id":"https://openalex.org/W2092401154","doi":"https://doi.org/10.1074/jbc.m703121200","title":"Integration of Inositol Phosphate Signaling Pathways via Human ITPK1","display_name":"Integration of Inositol Phosphate Signaling Pathways via Human ITPK1","publication_year":2007,"publication_date":"2007-07-07","ids":{"openalex":"https://openalex.org/W2092401154","doi":"https://doi.org/10.1074/jbc.m703121200","mag":"2092401154","pmid":"https://pubmed.ncbi.nlm.nih.gov/17616525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244811"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m703121200","doi":"https://doi.org/10.1074/jbc.m703121200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m703121200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m703121200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005830512","display_name":"Philip P. Chamberlain","orcid":"https://orcid.org/0000-0002-6407-7344","observed_orcids":["https://orcid.org/0000-0002-6407-7344"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip P. Chamberlain","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xun Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xun Qian","raw_affiliation_strings":["Inositol Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084642284","display_name":"Amanda R. Stiles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda R. Stiles","raw_affiliation_strings":["Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047085485","display_name":"Jaiesoon Cho","orcid":"https://orcid.org/0000-0002-4511-8032","observed_orcids":["https://orcid.org/0000-0002-4511-8032"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaiesoon Cho","raw_affiliation_strings":["Inositol Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053973876","display_name":"David H. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Jones","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, San Diego, California 92121","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067217335","display_name":"Scott A. Lesley","orcid":"https://orcid.org/0000-0002-7905-8840","observed_orcids":["https://orcid.org/0000-0002-7905-8840"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Lesley","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, San Diego, California 92121","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027373920","display_name":"Elizabeth A. Grabau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Grabau","raw_affiliation_strings":["Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013107971","display_name":"Stephen B. Shears","orcid":"https://orcid.org/0000-0001-7309-8916","observed_orcids":["https://orcid.org/0000-0001-7309-8916"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen B. Shears","raw_affiliation_strings":["Inositol Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016539643","display_name":"Glen Spraggon","orcid":"https://orcid.org/0000-0001-7880-8454","observed_orcids":["https://orcid.org/0000-0001-7880-8454"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Glen Spraggon","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, San Diego, California 92121","institution_ids":["https://openalex.org/I127128434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013107971","https://openalex.org/A5016539643"],"corresponding_institution_ids":["https://openalex.org/I127128434","https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.7207,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.8331988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"282","issue":"38","first_page":"28117","last_page":"28125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inositol-phosphate-signaling","display_name":"inositol phosphate signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nucleotide-binding","display_name":"nucleotide binding","score":0.6579999923706055},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.871999979019165},{"id":"https://openalex.org/keywords/enzyme-evolution","display_name":"enzyme evolution","score":0.6629999876022339},{"id":"https://openalex.org/keywords/phospholipase-c-signaling","display_name":"phospholipase C signaling","score":0.7599999904632568},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.8590511679649353},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.6625822186470032},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.6509090065956116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6423467993736267},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5529117584228516},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5398963689804077},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48696526885032654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45583298802375793},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.43027475476264954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4215920567512512},{"id":"https://openalex.org/C2781387506","wikidata":"https://www.wikidata.org/wiki/Q138145","display_name":"Inositol trisphosphate","level":4,"score":0.41249802708625793},{"id":"https://openalex.org/C66135807","wikidata":"https://www.wikidata.org/wiki/Q24726231","display_name":"Gq alpha subunit","level":4,"score":0.41169029474258423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3885428011417389},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3351013660430908},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23994383215904236},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.16436928510665894}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m703121200","doi":"https://doi.org/10.1074/jbc.m703121200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m703121200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17616525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17616525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2244811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244811","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m703121200","doi":"https://doi.org/10.1074/jbc.m703121200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m703121200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1252572669","display_name":"Inositol Signalling","funder_award_id":"Z01ES080046","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7295373465","display_name":null,"funder_award_id":"Z99-ES999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1512142615","https://openalex.org/W1521038582","https://openalex.org/W1539796472","https://openalex.org/W1558610458","https://openalex.org/W1561094053","https://openalex.org/W1726597626","https://openalex.org/W1810065192","https://openalex.org/W1968686367","https://openalex.org/W1988647322","https://openalex.org/W2001641653","https://openalex.org/W2004360551","https://openalex.org/W2007856178","https://openalex.org/W2008245136","https://openalex.org/W2016765195","https://openalex.org/W2023601239","https://openalex.org/W2023959712","https://openalex.org/W2031772330","https://openalex.org/W2032804212","https://openalex.org/W2033952130","https://openalex.org/W2034654184","https://openalex.org/W2035156848","https://openalex.org/W2037838485","https://openalex.org/W2038840577","https://openalex.org/W2066465046","https://openalex.org/W2069031972","https://openalex.org/W2071503618","https://openalex.org/W2080351019","https://openalex.org/W2090028833","https://openalex.org/W2090430216","https://openalex.org/W2092020049","https://openalex.org/W2093973853","https://openalex.org/W2103484811","https://openalex.org/W2105933335","https://openalex.org/W2114465292","https://openalex.org/W2117239890","https://openalex.org/W2126788666","https://openalex.org/W2144081223","https://openalex.org/W2146718650","https://openalex.org/W2257050615"],"related_works":["https://openalex.org/W7095164657","https://openalex.org/W2155043399","https://openalex.org/W569809972","https://openalex.org/W4390228384","https://openalex.org/W3044150028","https://openalex.org/W1981847269","https://openalex.org/W4407204980","https://openalex.org/W2131616659","https://openalex.org/W1600022110","https://openalex.org/W1999584710"],"abstract_inverted_index":{"Inositol":[0],"1,3,4-trisphosphate":[1],"5/6-kinase":[2],"(ITPK1)":[3],"is":[4,37,78,104],"a":[5,16,71,175,189,193],"reversible,":[6],"poly-specific":[7],"inositol":[8,31,48,63,67,81,107],"phosphate":[9,103,113,170],"kinase":[10],"that":[11,62,77,102,131],"has":[12,59],"been":[13,60],"implicated":[14],"as":[15],"modifier":[17],"gene":[18],"in":[19,70,135,141],"cystic":[20],"fibrosis.":[21],"Upon":[22],"activation":[23],"of":[24,42,73,150,178,188],"phospholipase":[25],"C":[26],"at":[27],"the":[28,34,74,92,136,185],"plasma":[29,85],"membrane,":[30],"1,4,5-trisphosphate":[32],"enters":[33],"cytosol":[35],"and":[36,44,52,163,181],"inter-converted":[38],"by":[39,126],"an":[40],"array":[41],"kinases":[43],"phosphatases":[45],"into":[46,184],"other":[47],"phosphates":[49,108],"with":[50],"diverse":[51],"critical":[53],"cellular":[54],"activities.":[55],"In":[56],"mammals":[57],"it":[58],"established":[61],"1,3,4-trisphosphate,":[64],"produced":[65],"from":[66,80,192],"1,4,5-trisphosphate,":[68],"lies":[69],"branch":[72],"metabolic":[75,194],"pathway":[76],"separate":[79],"3,4,5,6-tetrakisphosphate,":[82],"which":[83],"inhibits":[84],"membrane":[86],"chloride":[87],"channels.":[88],"We":[89,128],"have":[90],"determined":[91],"molecular":[93],"mechanism":[94,191],"for":[95],"communication":[96],"between":[97,106],"these":[98,132],"two":[99],"pathways,":[100],"showing":[101],"transferred":[105],"via":[109],"ITPK1-bound":[110],"nucleotide.":[111],"Intersubstrate":[112],"transfer":[114],"explains":[115],"how":[116],"competing":[117],"substrates":[118],"are":[119],"able":[120,158],"to":[121,159],"stimulate":[122],"each":[123],"others'":[124],"catalysis":[125],"ITPK1.":[127],"further":[129],"show":[130],"features":[133,157],"occur":[134],"human":[137,151],"protein,":[138],"but":[139],"not":[140],"plant":[142],"or":[143],"protozoan":[144],"homologues.":[145],"The":[146],"high":[147],"resolution":[148],"structure":[149],"ITPK1":[152],"identifies":[153],"novel":[154,176],"secondary":[155],"structural":[156],"impart":[160],"substrate":[161,179],"selectivity":[162],"enhance":[164],"nucleotide":[165],"binding,":[166],"thereby":[167],"promoting":[168],"intersubstrate":[169],"transfer.":[171],"Our":[172],"work":[173],"describes":[174],"mode":[177],"regulation":[180],"provides":[182],"insight":[183],"enzyme":[186],"evolution":[187],"signaling":[190],"role.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
