{"id":"https://openalex.org/W2092356369","doi":"https://doi.org/10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","title":"Nonlinear Effects in Asymmetric Synthesis and Stereoselective Reactions: Ten Years of Investigation","display_name":"Nonlinear Effects in Asymmetric Synthesis and Stereoselective Reactions: Ten Years of Investigation","publication_year":1998,"publication_date":"1998-11-16","ids":{"openalex":"https://openalex.org/W2092356369","doi":"https://doi.org/10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","mag":"2092356369","pmid":"https://pubmed.ncbi.nlm.nih.gov/29711141"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-3773%2819981116%2937%3A21%3C2922%3A%3AAID-ANIE2922%3E3.0.CO%3B2-1","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-3773%2819981116%2937%3A21%3C2922%3A%3AAID-ANIE2922%3E3.0.CO%3B2-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107385295","display_name":"Christian Girard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149758196","display_name":"Chimie ParisTech - PSL","ror":"https://ror.org/05q65zh81","country_code":"FR","type":"education","lineage":["https://openalex.org/I149758196","https://openalex.org/I190752583"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Girard","raw_affiliation_strings":["Laboratoire de Vectorisation Mol\u00e9culaire et Cellulaire, Ecole Nationale Sup\u00e9rieure de Chimie de Paris, 11, rue Pierre et Marie Curie, F-75231 Paris Cedex (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Vectorisation Mol\u00e9culaire et Cellulaire, Ecole Nationale Sup\u00e9rieure de Chimie de Paris, 11, rue Pierre et Marie Curie, F-75231 Paris Cedex (France)","institution_ids":["https://openalex.org/I149758196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049578590","display_name":"Henri Boris Kagan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210151467","display_name":"Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d'Orsay","ror":"https://ror.org/05wzh1m37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210151467"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Henri B. Kagan","raw_affiliation_strings":["Laboratoire des R\u00e9actions Organiques S\u00e9lectives, Institut de Chimie Mol\u00e9culaire d'Orsay, B\u00e2timent 420, Universit\u00e9 de Paris-Sud, F-91405 Orsay Cedex (France), Fax: (+33)\u2009169-15-46-80"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire des R\u00e9actions Organiques S\u00e9lectives, Institut de Chimie Mol\u00e9culaire d'Orsay, B\u00e2timent 420, Universit\u00e9 de Paris-Sud, F-91405 Orsay Cedex (France), Fax: (+33)\u2009169-15-46-80","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I4210151467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":27.6222,"has_fulltext":true,"cited_by_count":840,"citation_normalized_percentile":{"value":0.9993031,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"37","issue":"21","first_page":"2922","last_page":"2959"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13115","display_name":"Axial and Atropisomeric Chirality Synthesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/stereoselective-reactions","display_name":"stereoselective reactions","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nonlinear-effects","display_name":"nonlinear effects","score":0.8199999928474426},{"id":"https://openalex.org/keywords/enantiomeric-excess","display_name":"enantiomeric excess","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chiral-auxiliaries","display_name":"chiral auxiliaries","score":0.8610000014305115},{"id":"https://openalex.org/keywords/enantioselectivity","display_name":"enantioselectivity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/chiral-catalysis","display_name":"chiral catalysis","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.742633044719696},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.6585586071014404},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6048140525817871},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.5772060751914978},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.5392955541610718},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.537510335445404},{"id":"https://openalex.org/C186399060","wikidata":"https://www.wikidata.org/wiki/Q959962","display_name":"Diagram","level":2,"score":0.4922107756137848},{"id":"https://openalex.org/C3141732","wikidata":"https://www.wikidata.org/wiki/Q568761","display_name":"Enantiomeric excess","level":4,"score":0.4825141131877899},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.47380584478378296},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4632246494293213},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3988783359527588},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36824706196784973},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.26850253343582153},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2196134328842163},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.074787437915802},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.043708592653274536},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-3773%2819981116%2937%3A21%3C2922%3A%3AAID-ANIE2922%3E3.0.CO%3B2-1","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:29711141","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29711141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-3773(19981116)37:21<2922::aid-anie2922>3.0.co;2-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-3773%2819981116%2937%3A21%3C2922%3A%3AAID-ANIE2922%3E3.0.CO%3B2-1","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092356369.pdf","grobid_xml":"https://content.openalex.org/works/W2092356369.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W606968409","https://openalex.org/W1569052896","https://openalex.org/W2492579112","https://openalex.org/W4211186898","https://openalex.org/W6600992289","https://openalex.org/W6601566401","https://openalex.org/W6603122302","https://openalex.org/W6603410100","https://openalex.org/W6603904428","https://openalex.org/W6608854699","https://openalex.org/W6724777031","https://openalex.org/W6726050178","https://openalex.org/W6726067488","https://openalex.org/W6814321810","https://openalex.org/W6814351280"],"related_works":["https://openalex.org/W2950226701","https://openalex.org/W1980122052","https://openalex.org/W2069924568","https://openalex.org/W1969581331","https://openalex.org/W2000713249","https://openalex.org/W2022936125","https://openalex.org/W2071761581","https://openalex.org/W45084373","https://openalex.org/W2418807787","https://openalex.org/W2042049058"],"abstract_inverted_index":{"Who":[0],"would":[1],"have":[2,77],"thought":[3],"before":[4],"1986":[5],"that":[6,25,34],"an":[7,16,20,43],"enantiomerically":[8],"impure":[9],"catalyst":[10],"could":[11],"give":[12],"a":[13,59,78],"product":[14,40],"in":[15,86],"asymmetric":[17,44],"synthesis":[18,45],"with":[19],"enantiomeric":[21],"excess":[22],"higher":[23],"than":[24],"of":[26,38,53,72,80],"the":[27,35,39,50,54],"catalyst?":[28],"Until":[29],"then":[30],"it":[31],"was":[32,46],"assumed":[33],"ee":[36,51],"value":[37,52],"(eeprod)":[41],"from":[42],"linearly":[47],"correlated":[48],"to":[49],"chiral":[55],"auxiliary":[56],"(eeaux)\u2014in":[57],"fact":[58],"large":[60],"deviation":[61],"is":[62],"possible":[63],"(see":[64],"diagram).":[65],"These":[66],"nonlinear":[67],"effects":[68],"are":[69,84],"not":[70],"only":[71],"academic":[73],"interest":[74],"since":[75],"they":[76],"variety":[79],"practical":[81],"uses,":[82],"which":[83],"highlighted":[85],"this":[87],"review.":[88]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":35},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":26}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}