{"id":"https://openalex.org/W2092355445","doi":"https://doi.org/10.1095/biolreprod45.3.471","title":"Patterns of Circulating Gonadotropins and Ovarian Steroids during the First Periovulatory Period in the Developing Sheep1","display_name":"Patterns of Circulating Gonadotropins and Ovarian Steroids during the First Periovulatory Period in the Developing Sheep1","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W2092355445","doi":"https://doi.org/10.1095/biolreprod45.3.471","mag":"2092355445","pmid":"https://pubmed.ncbi.nlm.nih.gov/1782296"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod45.3.471","doi":"https://doi.org/10.1095/biolreprod45.3.471","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod45.3.471","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089112395","display_name":"Kathleen D. Ryan","orcid":"https://orcid.org/0000-0001-9277-6364","observed_orcids":["https://orcid.org/0000-0001-9277-6364"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen D. Ryan","raw_affiliation_strings":["Department of Biology, University of Michigan, Ann Arbor 48109-0404","Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Michigan, Ann Arbor 48109-0404","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023295035","display_name":"Robert L. Goodman","orcid":"https://orcid.org/0000-0003-4080-2596","observed_orcids":["https://orcid.org/0000-0003-4080-2596"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Goodman","raw_affiliation_strings":["Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110150179","display_name":"Fred J. Karsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred J. Karsch","raw_affiliation_strings":["Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015518126","display_name":"Sandra J. Legan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra J. Legan","raw_affiliation_strings":["Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110900180","display_name":"Douglas L. Foster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas L. Foster","raw_affiliation_strings":["Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Sciences Program, Departments of Biology, Obstetrics and Gynecology, and Physiology The University of Michigan, Ann Arbor, Michigan 48109\u20130404","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110900180"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":0.7552,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.72255018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"45","issue":"3","first_page":"471","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.22949999570846558,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.7639999985694885},{"id":"https://openalex.org/keywords/first-ovulation","display_name":"first ovulation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/preovulatory-surge","display_name":"preovulatory surge","score":0.675000011920929},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.902999997138977},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.953000009059906},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9639999866485596},{"id":"https://openalex.org/keywords/luteal-phase","display_name":"luteal phase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ovarian-steroids","display_name":"ovarian steroids","score":0.5730000138282776},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.5490000247955322},{"id":"https://openalex.org/keywords/female-lambs","display_name":"female lambs","score":0.796999990940094},{"id":"https://openalex.org/keywords/estrus","display_name":"estrus","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.911646842956543},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.7052789926528931},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5059289336204529},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4583742618560791},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45085448026657104},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.4356972873210907},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2635418176651001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.02996969223022461},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004971","descriptor_name":"Estrus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010060","descriptor_name":"Ovulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1095/biolreprod45.3.471","doi":"https://doi.org/10.1095/biolreprod45.3.471","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod45.3.471","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:1782296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1782296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.846.3658","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.846.3658","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biolreprod.org/content/45/3/471.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5331672060","display_name":null,"funder_award_id":"HD-12502","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8025648028","display_name":null,"funder_award_id":"HD-05463","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8509453405","display_name":null,"funder_award_id":"HD-08333","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033039929","https://openalex.org/W2016126711","https://openalex.org/W2155056328","https://openalex.org/W2045936678","https://openalex.org/W2045250897","https://openalex.org/W1999269330","https://openalex.org/W1976313277","https://openalex.org/W2128874593","https://openalex.org/W2144018912","https://openalex.org/W2085735884"],"abstract_inverted_index":{"This":[0],"report":[1],"provides":[2,232],"evidence":[3],"that":[4,18,146,189,205,223],"an":[5,216],"increment":[6],"in":[7,14,26,29,94,116,153,192,211,218],"serum":[8,72,95,124],"gonadotropin":[9,117,220],"levels":[10,96,118,126,221],"occurs":[11],"at":[12,40,209],"puberty":[13,55,210],"the":[15,21,51,86,107,114,130,136,163,206,212,224,228,233,236],"sheep":[16,214],"and":[17,65,80,100,185,222],"this":[19,30],"reflects":[20],"critical":[22],"hormonal":[23],"event":[24,208],"culminating":[25],"first":[27,108,164,237],"ovulation":[28,66],"species.":[31],"Blood":[32],"samples":[33],"were":[34,83,151],"collected":[35],"from":[36,227],"6":[37,157],"female":[38,213],"lambs":[39],"4-h":[41],"intervals":[42],"for":[43,89,235],"a":[44,160,169,186,193],"period":[45,88],"of":[46,54,58,71,75,97,111,139,156,162,173,197],"approximately":[47,103],"2":[48,155],"mo":[49],"around":[50],"expected":[52],"time":[53],"(32":[56],"wk":[57],"age)":[59],"until":[60],"behavioral":[61],"estrus":[62],"was":[63,67,179],"observed":[64],"verified":[68],"by":[69,181],"assay":[70],"progesterone.":[73],"Patterns":[74],"circulating":[76,219],"LH,":[77],"FSH,":[78],"progesterone,":[79],"estradiol":[81,125,183,225],"concentrations":[82],"characterized":[84],"during":[85,129],"peripubertal":[87],"each":[90],"lamb.":[91],"A":[92],"rise":[93,184],"both":[98],"LH":[99],"FSH":[101],"began":[102],"7-10":[104],"days":[105],"before":[106],"preovulatory":[109,137,187,238],"surge":[110,138,188],"gonadotropins.":[112],"Although":[113],"increase":[115,217],"occurred":[119],"gradually":[120],"over":[121],"several":[122],"days,":[123],"rose":[127],"only":[128,154],"final":[131],"40-60":[132],"h":[133],"prior":[134],"to":[135],"gonadotropin.":[140],"Serum":[141],"progesterone":[142],"profiles":[143],"revealed,":[144],"however,":[145],"normal":[147],"(14-16-day)":[148],"luteal":[149,171,195],"phases":[150],"induced":[152],"females":[158],"as":[159],"result":[161],"surge.":[165,239],"In":[166],"four":[167],"lambs,":[168],"short":[170],"phase":[172,196],"2.5":[174],"days'":[175,199],"duration":[176],"occurred,":[177],"which":[178],"followed":[180],"another":[182],"then":[190],"resulted":[191],"full":[194],"14":[198],"duration.":[200],"These":[201],"data":[202],"demonstrate":[203],"clearly":[204],"precipitating":[207],"is":[215],"secreted":[226],"newly":[229],"stimulated":[230],"follicle":[231],"signal":[234]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}