{"id":"https://openalex.org/W2092304683","doi":"https://doi.org/10.1016/0014-5793(94)00471-4","title":"Protein tyrosine phosphatase activity enhancement is induced upon Fc\u025b receptor activation of mast cells","display_name":"Protein tyrosine phosphatase activity enhancement is induced upon Fc\u025b receptor activation of mast cells","publication_year":1994,"publication_date":"1994-06-13","ids":{"openalex":"https://openalex.org/W2092304683","doi":"https://doi.org/10.1016/0014-5793(94)00471-4","mag":"2092304683","pmid":"https://pubmed.ncbi.nlm.nih.gov/8013632"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(94)00471-4","doi":"https://doi.org/10.1016/0014-5793(94)00471-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(94)00471-4","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036401896","display_name":"Christiane S. Hampe","orcid":"https://orcid.org/0000-0001-9111-6671","observed_orcids":["https://orcid.org/0000-0001-9111-6671"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"C S Hampe","raw_affiliation_strings":["Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021244474","display_name":"Israel Pecht","orcid":"https://orcid.org/0000-0002-1883-9547","observed_orcids":["https://orcid.org/0000-0002-1883-9547"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"I Pecht","raw_affiliation_strings":["Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Immunology, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.8856,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72303889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"346","issue":"2-3","first_page":"194","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.08489999920129776,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fc-epsilon-receptor-i","display_name":"Fc epsilon receptor I","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/receptor-clustering","display_name":"receptor clustering","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mucosal-mast-cells","display_name":"mucosal mast cells","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.8643110394477844},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.6268779635429382},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6228682398796082},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6016399264335632},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5538415908813477},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5374323725700378},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5289003252983093},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5190101861953735},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5069491863250732},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47532087564468384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46069997549057007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4260520040988922},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3876858353614807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3751581907272339},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2114650309085846},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1664847433567047}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004140","descriptor_name":"Dinitrophenols","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(94)00471-4","doi":"https://doi.org/10.1016/0014-5793(94)00471-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(94)00471-4","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:8013632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8013632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1482211797","https://openalex.org/W1487822346","https://openalex.org/W1529522766","https://openalex.org/W1537610839","https://openalex.org/W1567044759","https://openalex.org/W1673236791","https://openalex.org/W1704017123","https://openalex.org/W1964764518","https://openalex.org/W1968585354","https://openalex.org/W1977984433","https://openalex.org/W1986549185","https://openalex.org/W1988960711","https://openalex.org/W2002228183","https://openalex.org/W2010697345","https://openalex.org/W2012681367","https://openalex.org/W2024083409","https://openalex.org/W2024519053","https://openalex.org/W2025336294","https://openalex.org/W2032359283","https://openalex.org/W2035377569","https://openalex.org/W2042248645","https://openalex.org/W2048345403","https://openalex.org/W2053446564","https://openalex.org/W2060101293","https://openalex.org/W2067226707","https://openalex.org/W2069240478","https://openalex.org/W2070431736","https://openalex.org/W2071984343","https://openalex.org/W2077310918","https://openalex.org/W2103174300","https://openalex.org/W2139494439","https://openalex.org/W2172937773","https://openalex.org/W2410559866"],"related_works":["https://openalex.org/W1971579761","https://openalex.org/W2049571223","https://openalex.org/W2071229451","https://openalex.org/W2134606648","https://openalex.org/W2071984343","https://openalex.org/W2096982442","https://openalex.org/W4251889059","https://openalex.org/W1986549185","https://openalex.org/W2044618871","https://openalex.org/W2886849469"],"abstract_inverted_index":{"Immunological":[0],"stimulation":[1,101],"of":[2,28,35,75,83,108,116],"rat":[3],"mucosal":[4],"type":[5,13],"mast":[6],"cells":[7],"(line":[8],"RBL-2H3)":[9],"by":[10,102],"clustering":[11],"the":[12,33,53,71,84,117],"I":[14],"Fc":[15,62,103,118],"epsilon":[16,19,63,104,119],"receptor":[17],"(Fc":[18],"RI)":[20],"causes":[21],"a":[22,88],"fast":[23],"and":[24,41,73],"transient":[25],"tyrosine":[26,38,43],"phosphorylation":[27],"several":[29],"proteins.":[30],"This":[31],"implied":[32],"involvement":[34,113],"both,":[36],"protein":[37,42],"kinases":[39],"(PTKs)":[40],"phosphatases":[44],"(PTPases)":[45],"in":[46,56,78,114],"that":[47],"process.":[48],"In":[49,81],"order":[50],"to":[51,66,93,97],"identify":[52],"PTPases":[54,76],"involved":[55],"these":[57],"very":[58],"early":[59],"steps":[60],"coupling":[61],"RI":[64,105,120],"stimulus":[65],"cell":[67,100],"response,":[68],"we":[69],"undertook":[70],"purification":[72],"characterization":[74],"present":[77],"RBL-2H3":[79],"cells.":[80],"one":[82],"cells'":[85],"membranal":[86],"fractions,":[87],"PTPase":[89],"activity":[90,110],"was":[91],"found":[92],"be":[94],"enhanced":[95],"2-":[96],"3-fold":[98],"upon":[99],"clustering.":[106],"Characterization":[107],"this":[109],"implies":[111],"its":[112],"control":[115],"signalling":[121],"cascade.":[122]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}