{"id":"https://openalex.org/W2092303687","doi":"https://doi.org/10.1016/j.ab.2010.05.033","title":"Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2\u2014Discovery of LRRK2 inhibitors","display_name":"Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2\u2014Discovery of LRRK2 inhibitors","publication_year":2010,"publication_date":"2010-06-03","ids":{"openalex":"https://openalex.org/W2092303687","doi":"https://doi.org/10.1016/j.ab.2010.05.033","mag":"2092303687","pmid":"https://pubmed.ncbi.nlm.nih.gov/20566370","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921631"},"language":"en","primary_location":{"id":"doi:10.1016/j.ab.2010.05.033","doi":"https://doi.org/10.1016/j.ab.2010.05.033","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ab.2010.05.033","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921631","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100617377","display_name":"Min Liu","orcid":"https://orcid.org/0000-0003-0500-3246","observed_orcids":["https://orcid.org/0000-0003-0500-3246"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Liu","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women's Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA. mliu@rics.bwh.harvard.edu","Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women's Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA. mliu@rics.bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071096381","display_name":"Shibu M. Poulose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111395","display_name":"Jean Mayer Human Nutrition Research Center on Aging","ror":"https://ror.org/01d0zz505","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210111395","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shibu Poulose","raw_affiliation_strings":["Jean Mayer Human Nutrition Research Center on Aging, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jean Mayer Human Nutrition Research Center on Aging, Boston, MA, USA","institution_ids":["https://openalex.org/I4210111395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052788632","display_name":"Eli Schuman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Schuman","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028881320","display_name":"Alexandra D. Zaitsev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra D. Zaitsev","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072424087","display_name":"Brittany Dobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany Dobson","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014995961","display_name":"Ken Auerbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Auerbach","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005172010","display_name":"Kathleen I. Seyb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Seyb","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055567926","display_name":"Gregory D. Cuny","orcid":"https://orcid.org/0000-0002-3188-4748","observed_orcids":["https://orcid.org/0000-0002-3188-4748"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D. Cuny","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109911305","display_name":"Marcie A. Glicksman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcie A. Glicksman","raw_affiliation_strings":["Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Drug Discovery in Neurodegeneration, Brigham and Women\u2019s Hospital, 65 Landsdowne Street, Fourth Floor, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016533406","display_name":"Ross L. Stein","orcid":"https://orcid.org/0000-0002-1410-0200","observed_orcids":["https://orcid.org/0000-0002-1410-0200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ross L. Stein","raw_affiliation_strings":["Discovery Research, Sirtris Pharmaceuticals, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research, Sirtris Pharmaceuticals, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021959959","display_name":"Zhenyu Yue","orcid":"https://orcid.org/0000-0001-8730-8515","observed_orcids":["https://orcid.org/0000-0001-8730-8515"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenyu Yue","raw_affiliation_strings":["Department of Neurology and Neuroscience, Mount Sinai School of Medicine, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Mount Sinai School of Medicine, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100617377"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":2.0922,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86715165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"404","issue":"2","first_page":"186","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/leucine-rich-repeat-kinase-2","display_name":"leucine-rich repeat kinase 2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lrrk2-inhibitors","display_name":"LRRK2 inhibitors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tr-fret-assay","display_name":"TR-FRET assay","score":0.7789999842643738},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.921999990940094},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8140000104904175},{"id":"https://openalex.org/keywords/gtpase-domain","display_name":"GTPase domain","score":0.7599999904632568},{"id":"https://openalex.org/keywords/g2019s-mutation","display_name":"G2019S mutation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"kinase domain","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.8826447129249573},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.7303187847137451},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6863616704940796},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5196912884712219},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.4973473846912384},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.49230802059173584},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.4787803888320923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46249890327453613},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4587242305278778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45740488171577454},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.45529699325561523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43255186080932617},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4243537485599518},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.42015066742897034},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4000881314277649},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3924698531627655},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3692164719104767},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.28087058663368225},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2750869393348694},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12196671962738037},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.12027162313461304}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ab.2010.05.033","doi":"https://doi.org/10.1016/j.ab.2010.05.033","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ab.2010.05.033","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},{"id":"pmid:20566370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20566370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2177644","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921631","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2921631","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921631","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Biochem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2177644","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2921631","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2418441838","display_name":"Molecular Mechanism of LRRK2 Biology and Pathology in Parkinson's Disease","funder_award_id":"R01NS060809","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8107672886","display_name":"National Center for Drug Discovery in Neurodegeneration","funder_award_id":"U24NS049339","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W1518101797","https://openalex.org/W1561072761","https://openalex.org/W1970848642","https://openalex.org/W1971064755","https://openalex.org/W1986216002","https://openalex.org/W1992365739","https://openalex.org/W2003883601","https://openalex.org/W2006875797","https://openalex.org/W2032206743","https://openalex.org/W2032544795","https://openalex.org/W2036496617","https://openalex.org/W2042949114","https://openalex.org/W2045402408","https://openalex.org/W2050902269","https://openalex.org/W2063127941","https://openalex.org/W2100300726","https://openalex.org/W2100894616","https://openalex.org/W2113282929","https://openalex.org/W2116200652","https://openalex.org/W2120262230","https://openalex.org/W2160484806","https://openalex.org/W6633570245"],"related_works":["https://openalex.org/W4249263038","https://openalex.org/W2032544795","https://openalex.org/W2009303018","https://openalex.org/W1992975140","https://openalex.org/W2340373720","https://openalex.org/W2071867431","https://openalex.org/W3193261673","https://openalex.org/W1518101797","https://openalex.org/W2124681346","https://openalex.org/W2415908252"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}