{"id":"https://openalex.org/W2092239645","doi":"https://doi.org/10.1113/expphysiol.1996.sp003992","title":"Effects of acetylcholine on a slow voltage\u2010activated non\u2010selective cation current mediated by non\u2010nicotinic receptors on isolated Ascaris muscle bags","display_name":"Effects of acetylcholine on a slow voltage\u2010activated non\u2010selective cation current mediated by non\u2010nicotinic receptors on isolated Ascaris muscle bags","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2092239645","doi":"https://doi.org/10.1113/expphysiol.1996.sp003992","mag":"2092239645","pmid":"https://pubmed.ncbi.nlm.nih.gov/8960698"},"language":"en","primary_location":{"id":"doi:10.1113/expphysiol.1996.sp003992","doi":"https://doi.org/10.1113/expphysiol.1996.sp003992","is_oa":true,"landing_page_url":"https://doi.org/10.1113/expphysiol.1996.sp003992","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.1996.sp003992","source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.1996.sp003992","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033749081","display_name":"Richard J. Martin","orcid":"https://orcid.org/0000-0003-2422-1847","observed_orcids":["https://orcid.org/0000-0003-2422-1847"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"RJ Martin","raw_affiliation_strings":["Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, Summerhall, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, Summerhall, University of Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043895155","display_name":"M. A. Valkanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210134208","display_name":"Institute of Biophysics","ror":"https://ror.org/034g04n73","country_code":"BG","type":"facility","lineage":["https://openalex.org/I4210134208"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["BG","GB"],"is_corresponding":false,"raw_author_name":"MA Valkanov","raw_affiliation_strings":["Department of Preclinical Veterinary Sciences , Royal (Dick) School of Veterinary Studies , Summerhall , University of Edinburgh , Edinburgh EH9 JQH , UK and","Institute of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical Veterinary Sciences , Royal (Dick) School of Veterinary Studies , Summerhall , University of Edinburgh , Edinburgh EH9 JQH , UK and","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Institute of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210134208"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":null,"fwci":0.3787,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.57848101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"6","first_page":"909","last_page":"925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.11010000109672546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-selective-cation-channels","display_name":"non-selective cation channels","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ascaris-suum","display_name":"Ascaris suum","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nematode-muscle","display_name":"nematode muscle","score":0.7879999876022339},{"id":"https://openalex.org/keywords/fmrfamide","display_name":"FMRFamide","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tubocurarine","display_name":"tubocurarine","score":0.8119999766349792},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tail-current","display_name":"tail current","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.7785018682479858},{"id":"https://openalex.org/C2780492224","wikidata":"https://www.wikidata.org/wiki/Q310838","display_name":"Ascaris","level":3,"score":0.739723265171051},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6470112204551697},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.6289136409759521},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.555491030216217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5546188950538635},{"id":"https://openalex.org/C45855136","wikidata":"https://www.wikidata.org/wiki/Q4734890","display_name":"Ganglion type nicotinic receptor","level":5,"score":0.4354475736618042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3767164945602417},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3734026551246643},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.3689741790294647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3575524091720581},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23808088898658752},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09595069289207458},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.0740169882774353}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000871","descriptor_name":"Anthelmintics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001464","descriptor_name":"Barium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002586","descriptor_name":"Cesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017165","descriptor_name":"Ascaris suum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017165","descriptor_name":"Ascaris suum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019835","descriptor_name":"FMRFamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1113/expphysiol.1996.sp003992","doi":"https://doi.org/10.1113/expphysiol.1996.sp003992","is_oa":true,"landing_page_url":"https://doi.org/10.1113/expphysiol.1996.sp003992","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.1996.sp003992","source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},{"id":"pmid:8960698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8960698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1113/expphysiol.1996.sp003992","doi":"https://doi.org/10.1113/expphysiol.1996.sp003992","is_oa":true,"landing_page_url":"https://doi.org/10.1113/expphysiol.1996.sp003992","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.1996.sp003992","source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092239645.pdf","grobid_xml":"https://content.openalex.org/works/W2092239645.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1970988869","https://openalex.org/W2036196221","https://openalex.org/W2040911422","https://openalex.org/W2075068003","https://openalex.org/W2099656068","https://openalex.org/W2159904733","https://openalex.org/W2162301608","https://openalex.org/W2397367860","https://openalex.org/W2409286168","https://openalex.org/W4251010516","https://openalex.org/W4300791033","https://openalex.org/W4301033841","https://openalex.org/W7073695100","https://openalex.org/W7073739183","https://openalex.org/W7073998224"],"related_works":["https://openalex.org/W2126704043","https://openalex.org/W2036196221","https://openalex.org/W2199016323","https://openalex.org/W7096613466","https://openalex.org/W2095890534","https://openalex.org/W2046876882","https://openalex.org/W2044895786","https://openalex.org/W2411488674","https://openalex.org/W119699966","https://openalex.org/W2052251235"],"abstract_inverted_index":{"Isolated":[0],"muscle":[1],"bags":[2,17],"from":[3,43],"the":[4,45,68,71,101,111,114,127,134,152,170,185,190,200,219,229,246,252,259,267,273],"parasitic":[5],"nematode":[6],"Ascaris":[7],"suum":[8],"were":[9,18,221],"prepared":[10],"by":[11,110,165],"collagenase":[12],"treatment":[13],"and":[14,29,31,37,95,136,214],"dissection.":[15],"Single":[16],"mounted":[19],"in":[20,53,113,142,151,194,245],"a":[21,56,76,82,117,173,233],"V-shaped":[22],"plastic":[23],"pipette":[24],"for":[25],"voltage":[26,41,88],"clamp":[27],"application":[28],"intra-":[30,36,213],"extracellular":[32,38,215],"perfusion.":[33],"With":[34],"'physiological'":[35],"solutions,":[39],"depolarizing":[40,72],"steps":[42,89],"near":[44,85],"normal":[46],"resting":[47],"membrane":[48,231],"potential,":[49],"-40":[50],"mV,":[51],"produced":[52,90,148],"leak-corrected":[54],"currents,":[55],"slowly":[57],"activating":[58],"outward":[59,92,97],"current":[60,80,93,99],"at":[61,126],"potentials":[62],"more":[63],"positive":[64],"than":[65,145],"-20mV.":[66,86],"At":[67],"end":[69],"of":[70,116,133,154,158,172,187,202,243,248,254,264,269],"pulse":[73],"there":[74],"was":[75,160,205,209],"slow":[77,234],"inward":[78],"tail":[79,98],"with":[81,100],"reversal":[83,103],"potential":[84],"Hyperpolarizing":[87],"an":[91,96,149],"relaxation":[94],"same":[102],"potential.":[104],"The":[105,156,241,262],"observations":[106],"can":[107],"be":[108],"explained":[109],"presence":[112,171,247,253,268],"bag":[115,230,260,274],"non-selective":[118,236],"cation":[119,237],"channel":[120,135,238],"current,":[121,239],"Ibcat,":[122],"that":[123,218,228],"activates":[124],"spontaneously":[125],"holding":[128],"potential;":[129],"depolarization":[130],"increases":[131],"opening":[132],"hyperpolarization":[137],"decreases":[138],"opening.":[139],"Bath-applied":[140],"acetylcholine":[141,159,175,188,244,256],"concentrations":[143,195],"greater":[144],"10(-7)":[146],"M":[147],"increase":[150],"amplitude":[153,201],"Ibcat.":[155,203,240],"effect":[157,186,242,263],"not":[161],"antagonized":[162],"or":[163],"prevented":[164],"100":[166],"microM":[167],"tubocurarine,":[168],"suggesting":[169],"non-nicotinic":[174,255],"receptor.":[176],"Atropine":[177],"(100":[178],"microM)":[179],"had":[180],"no":[181],"detectable":[182],"influence":[183],"on":[184,258,272],"but":[189],"FMRFamide":[191],"peptide,":[192],"PF1,":[193],">":[196],"1":[197],"microM,":[198],"reduced":[199],"Ibcat":[204],"maintained":[206],"when":[207],"Cs+":[208],"used":[210],"to":[211,223],"replace":[212],"cations,":[216],"showing":[217],"channels":[220],"permeable":[222],"Cs+.":[224],"It":[225],"is":[226],"concluded":[227],"possesses":[232],"voltage-activated":[235],"nicotinic":[249],"antagonist":[250],"indicates":[251],"receptors":[257,271],"membrane.":[261,275],"PF1":[265,270],"indicated":[266]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}