{"id":"https://openalex.org/W2092232641","doi":"https://doi.org/10.1210/endo-120-3-874","title":"Functional Variations among Prolactin Cells from Different Pituitary Regions*","display_name":"Functional Variations among Prolactin Cells from Different Pituitary Regions*","publication_year":1987,"publication_date":"1987-03-01","ids":{"openalex":"https://openalex.org/W2092232641","doi":"https://doi.org/10.1210/endo-120-3-874","mag":"2092232641","pmid":"https://pubmed.ncbi.nlm.nih.gov/3100286"},"language":"en","primary_location":{"id":"doi:10.1210/endo-120-3-874","doi":"https://doi.org/10.1210/endo-120-3-874","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-120-3-874","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109226141","display_name":"F. R. Boockfor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. R. BOOCKFOR","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Medical University of South Carolina Charleston, South Carolina 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Medical University of South Carolina Charleston, South Carolina 29425","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111820231","display_name":"L. Stephen Frawley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. STEPHEN FRAWLEY","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Medical University of South Carolina Charleston, South Carolina 29425"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Medical University of South Carolina Charleston, South Carolina 29425","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.503,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.97336962,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"120","issue":"3","first_page":"874","last_page":"879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactotrophs","display_name":"lactotrophs","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pituitary-adenohypophysis","display_name":"pituitary adenohypophysis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.4569999873638153},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.6340000033378601},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gh-releasing-factor","display_name":"GH-releasing factor","score":0.7260000109672546},{"id":"https://openalex.org/keywords/hypothalamic-regulation","display_name":"hypothalamic regulation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/prolactin-secretion","display_name":"prolactin secretion","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7870446443557739},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7781655192375183},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.7098504900932312},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.5515992045402527},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.5212317705154419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5079002976417542},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.5049136281013489},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.5018384456634521},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.38387924432754517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3727145493030548},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16524618864059448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12771070003509521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06593510508537292}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006462","descriptor_name":"Hemolytic Plaque Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-120-3-874","doi":"https://doi.org/10.1210/endo-120-3-874","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-120-3-874","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:3100286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3100286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5726758228","display_name":null,"funder_award_id":"AM-38212","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W650038680","https://openalex.org/W1028186983","https://openalex.org/W1979545125","https://openalex.org/W1980983147","https://openalex.org/W1982397116","https://openalex.org/W1984097353","https://openalex.org/W1993789735","https://openalex.org/W1998503558","https://openalex.org/W1999850737","https://openalex.org/W2000272090","https://openalex.org/W2018791707","https://openalex.org/W2027090499","https://openalex.org/W2036274563","https://openalex.org/W2036689132","https://openalex.org/W2041208207","https://openalex.org/W2044852976","https://openalex.org/W2044957410","https://openalex.org/W2050563481","https://openalex.org/W2051321517","https://openalex.org/W2058433375","https://openalex.org/W2115887017","https://openalex.org/W2140429388","https://openalex.org/W2149405070","https://openalex.org/W2152038541","https://openalex.org/W2276917974","https://openalex.org/W2751859373"],"related_works":["https://openalex.org/W2116277848","https://openalex.org/W2061122184","https://openalex.org/W2051321517","https://openalex.org/W2036689132","https://openalex.org/W2149405070","https://openalex.org/W2091798413","https://openalex.org/W1979545125","https://openalex.org/W2055667160","https://openalex.org/W4230922841","https://openalex.org/W2082220352"],"abstract_inverted_index":{"Reverse":[0],"hemolytic":[1],"plaque":[2,71,83,106,113,131,188],"assays":[3,72,84,189],"were":[4,50,57,67],"used":[5],"to":[6,16,69,98,117,177,190,293],"compare":[7],"the":[8,17,32,38,55,62,75,109,193,215,226,240,249,255,258,271,282,290],"responsiveness":[9,250],"of":[10,20,43,79,104,111,195,234,260,273,289],"cells":[11,56,66,123,150,169,196],"from":[12,31,45,93,124,147,170,262],"different":[13],"pituitary":[14,172,291],"regions":[15,173],"modulatory":[18],"effects":[19],"human":[21],"pancreatic":[22],"GH-releasing":[23],"factor":[24],"(GRF),":[25],"TRH,":[26,155],"and":[27,37,54,81,90,119,209,217,264,269],"dopamine":[28],"(DA).":[29],"Tissues":[30],"peripheral":[33],"rim":[34],"(outer":[35],"zone)":[36,42],"central":[39],"region":[40,288],"(inner":[41],"adenohypophyses":[44],"day":[46],"10":[47],"lactating":[48],"rats":[49],"dispersed":[51],"with":[52,86,100,135,248],"trypsin,":[53],"placed":[58],"into":[59],"culture.":[60],"On":[61],"following":[63],"day,":[64],"these":[65,125,171,274],"subjected":[68],"GH":[70,105,208],"(conducted":[73],"in":[74,115,280,284],"presence":[76],"or":[77,87,203],"absence":[78],"GRF)":[80],"PRL":[82,112,199,210,261],"(performed":[85],"without":[88],"TRH":[89,118,136],"DA).":[91],"Cells":[92],"both":[94,207],"zones":[95],"responded":[96],"similarly":[97],"GRF":[99],"a":[101,230,286],"rapid":[102],"acceleration":[103],"formation.":[107],"However,":[108],"rate":[110],"formation":[114,146],"response":[116],"DA":[120],"differed":[121,213],"between":[122,214],"regions.":[126],"For":[127],"outer":[128,218,227],"zone":[129,149,228],"cells,":[130],"development":[132],"increased":[133],"greatly":[134],"treatment,":[137],"but":[138,156,166],"was":[139,151],"only":[140,200],"moderately":[141],"affected":[142],"by":[143,154,159],"DA.":[144,160],"Plaque":[145],"inner":[148,216,241],"influenced":[152],"slightly":[153],"markedly":[157],"inhibited":[158],"These":[161,243],"results":[162],"suggest":[163],"that":[164,197,205,225,257,270],"PRL,":[165],"not":[167],"GH,":[168],"are":[174],"differentially":[175],"responsive":[176],"at":[178],"least":[179],"two":[180,275],"hypothalamic":[181,294],"secretagogues.":[182],"We":[183],"then":[184],"performed":[185],"fixed":[186],"sequential":[187],"determine":[191],"whether":[192],"proportions":[194],"released":[198,206],"(classical":[201],"mammotropes)":[202],"those":[204],"(mammosomatotropes)":[211],"also":[212],"zones.":[219],"Using":[220],"this":[221],"approach,":[222],"we":[223],"found":[224],"contained":[229],"much":[231],"larger":[232],"proportion":[233],"dual":[235],"hormone":[236],"secretors":[237],"than":[238],"did":[239],"zone.":[242],"results,":[244],"when":[245],"taken":[246],"together":[247],"differences":[251],"discussed":[252],"above,":[253],"raise":[254],"possibility":[256],"release":[259],"mammotropes":[263],"mammosomatotropes":[265],"is":[266],"regulated":[267],"differently":[268],"ratio":[272],"cell":[276],"types":[277],"may":[278],"dictate,":[279],"part,":[281],"manner":[283],"which":[285],"specific":[287],"responds":[292],"input.":[295]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}