{"id":"https://openalex.org/W2092192589","doi":"https://doi.org/10.1016/s0014-2999(96)00906-5","title":"Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A receptors","display_name":"Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A receptors","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2092192589","doi":"https://doi.org/10.1016/s0014-2999(96)00906-5","mag":"2092192589","pmid":"https://pubmed.ncbi.nlm.nih.gov/9085039"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(96)00906-5","doi":"https://doi.org/10.1016/s0014-2999(96)00906-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-2999(96)00906-5","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014299996009065/pdf","source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0014299996009065/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072395467","display_name":"Anissa Abi\u2010Dargham","orcid":"https://orcid.org/0000-0002-5039-5069","observed_orcids":["https://orcid.org/0000-0002-5039-5069"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anissa Abi-Dargham","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084979953","display_name":"Yolanda Zea\u2010Ponce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yolanda Zea-Ponce","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030100014","display_name":"Dirk Terriere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dirk Terriere","raw_affiliation_strings":["VUB-Cyclotron, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VUB-Cyclotron, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110180584","display_name":"Mohamed Al-Tikriti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Al-Tikriti","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112761609","display_name":"Ronald M. Baldwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M Baldwin","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109067382","display_name":"Paul B. Hoffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Hoffer","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012699156","display_name":"Dennis S. Charney","orcid":"https://orcid.org/0000-0003-0610-3433","observed_orcids":["https://orcid.org/0000-0003-0610-3433"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Charney","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111527585","display_name":"Jos\u00e9e E. Leysen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jos\u00e9e E Leysen","raw_affiliation_strings":["Janssen Research Foundation, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research Foundation, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087635866","display_name":"Marc A. Laruelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Laruelle","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068527894","display_name":"John J. R. Mertens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"John Mertens","raw_affiliation_strings":["VUB-Cyclotron, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VUB-Cyclotron, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079125204","display_name":"Robert B. Innis","orcid":"https://orcid.org/0000-0003-1238-7209","observed_orcids":["https://orcid.org/0000-0003-1238-7209"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B Innis","raw_affiliation_strings":["Yale University School of Medicine/VA Medical Center, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine/VA Medical Center, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072395467"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":{"value":3230,"currency":"USD","value_usd":3230},"fwci":0.6553,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.64542819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"321","issue":"3","first_page":"285","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.1768999993801117,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0820000022649765,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/serotonin-receptor-imaging","display_name":"serotonin receptor imaging","score":0.8029999732971191},{"id":"https://openalex.org/keywords/spect-tracers","display_name":"SPECT radiotracer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/radioiodination","display_name":"radioiodination","score":0.5979999899864197},{"id":"https://openalex.org/keywords/baboon-brain","display_name":"baboon brain","score":0.7889999747276306},{"id":"https://openalex.org/keywords/binding-potential","display_name":"binding potential","score":0.7960000038146973},{"id":"https://openalex.org/keywords/brain-uptake","display_name":"brain uptake","score":0.5220000147819519},{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":0.878000020980835},{"id":"https://openalex.org/keywords/raclopride","display_name":"raclopride","score":0.9049999713897705},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7350000143051147},{"id":"https://openalex.org/keywords/time-activity-curves","display_name":"time-activity curves","score":0.7360000014305115},{"id":"https://openalex.org/keywords/receptor-quantification","display_name":"receptor quantification","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2777785214","wikidata":"https://www.wikidata.org/wiki/Q415997","display_name":"Ketanserin","level":5,"score":0.8876370787620544},{"id":"https://openalex.org/C2781069445","wikidata":"https://www.wikidata.org/wiki/Q7279814","display_name":"Raclopride","level":4,"score":0.8506479263305664},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6956260800361633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5838156938552856},{"id":"https://openalex.org/C2779190346","wikidata":"https://www.wikidata.org/wiki/Q3801335","display_name":"Iodine-123","level":2,"score":0.5740536451339722},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.5631754994392395},{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.5136181712150574},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5054187774658203},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4990243911743164},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.4523927569389343},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.43876945972442627},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.4294695556163788},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4265784025192261},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41832488775253296},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4156598150730133},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.4058417081832886},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3730149567127228},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3039902448654175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19370442628860474},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19293347001075745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18425825238227844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18285974860191345}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007650","descriptor_name":"Ketanserin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012457","descriptor_name":"Salicylamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020891","descriptor_name":"Raclopride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0014-2999(96)00906-5","doi":"https://doi.org/10.1016/s0014-2999(96)00906-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-2999(96)00906-5","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014299996009065/pdf","source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:9085039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9085039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:14193","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/preclinical-evaluation-of-123ir93274-as-a-spect-radiotracer-for-imaging-5ht2a-receptors(ad8db082-dee9-4b88-9aeb-f4321f5a3305).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0014-2999(96)00906-5","doi":"https://doi.org/10.1016/s0014-2999(96)00906-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-2999(96)00906-5","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014299996009065/pdf","source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092192589.pdf","grobid_xml":"https://content.openalex.org/works/W2092192589.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1540821006","https://openalex.org/W1601342503","https://openalex.org/W1957103591","https://openalex.org/W1967078951","https://openalex.org/W1968884554","https://openalex.org/W1984692581","https://openalex.org/W1985538500","https://openalex.org/W1996797606","https://openalex.org/W1997485587","https://openalex.org/W2000030766","https://openalex.org/W2000460121","https://openalex.org/W2001310902","https://openalex.org/W2005956625","https://openalex.org/W2010582729","https://openalex.org/W2017040809","https://openalex.org/W2017273367","https://openalex.org/W2018129665","https://openalex.org/W2018479022","https://openalex.org/W2020062723","https://openalex.org/W2022455207","https://openalex.org/W2032457236","https://openalex.org/W2045718077","https://openalex.org/W2046045427","https://openalex.org/W2047029640","https://openalex.org/W2049299233","https://openalex.org/W2055779291","https://openalex.org/W2056674018","https://openalex.org/W2059191745","https://openalex.org/W2063017390","https://openalex.org/W2081880500","https://openalex.org/W2088474260","https://openalex.org/W2089785160","https://openalex.org/W2089923964","https://openalex.org/W2091806102","https://openalex.org/W2092855120","https://openalex.org/W2109582544","https://openalex.org/W2112911894","https://openalex.org/W2121887890","https://openalex.org/W2123596761","https://openalex.org/W2134560546","https://openalex.org/W2151266799","https://openalex.org/W2163254941","https://openalex.org/W2256578114","https://openalex.org/W2302121233","https://openalex.org/W2304626012","https://openalex.org/W2307936244","https://openalex.org/W2400755806","https://openalex.org/W2922915278","https://openalex.org/W3152410314","https://openalex.org/W6823787695"],"related_works":["https://openalex.org/W2069395267","https://openalex.org/W4254602759","https://openalex.org/W2317464727","https://openalex.org/W2026572954","https://openalex.org/W2028342656","https://openalex.org/W1944152481","https://openalex.org/W1982204894","https://openalex.org/W2079424010","https://openalex.org/W2039605495","https://openalex.org/W2151761019"],"abstract_inverted_index":{"Studies":[0],"in":[1,34,49,56,64,81,92,155,179,199,203,210,223],"rodents":[2],"have":[3],"suggested":[4],"that":[5],"the":[6,35,44,65,68,75,89,93,97,118,130,133,152,156,180,202,224],"radioiodinated":[7],"5-HT2A":[8,32,76,112,122,208,221],"receptor":[9,77,101],"antagonist":[10,78,102],"[123I]R93274":[11,48,107,125,215],"(123-iodine-N-[(3-p-fluorophenyl-1-propyl)-4-methyl-4-piperidinyl]-4-ami":[12],"no-":[13],"5-iodo-2-methoxybenzamide)":[14],"(Kd":[15],"=":[16],"0.1":[17],"nM)":[18],"might":[19],"be":[20],"a":[21,147,192],"promising":[22],"single":[23],"photon":[24],"emission":[25],"computerized":[26],"tomography":[27],"(SPECT)":[28],"radiotracer":[29],"to":[30,88],"image":[31],"receptors":[33,113,123,209,222],"living":[36],"human":[37],"brain.":[38,212],"In":[39,213],"this":[40],"study,":[41],"we":[42],"characterized":[43],"brain":[45,52,108,157,226],"uptake":[46,53,61],"of":[47,71,74,83,96,111,121,132,137,151,163,207,220],"baboons.":[50],"Highest":[51],"was":[54,62,114],"observed":[55,63,91],"cortical":[57,84],"areas,":[58],"while":[59],"lower":[60],"striatum":[66],"and":[67,85,135,158,172,183,218],"cerebellum.":[69,94],"Injection":[70,95],"pharmacological":[72],"doses":[73],"ketanserin":[79],"resulted":[80],"reduction":[82],"striatal":[86,184],"radioactivities":[87],"level":[90],"selective":[98],"dopamine":[99],"D2":[100],"raclopride":[103],"did":[104],"not":[105],"affect":[106],"uptake.":[109],"Quantification":[110],"achieved":[115],"by":[116],"measuring":[117],"binding":[119,127,141],"potential":[120,128,142,161],"for":[124],"(the":[126],"is":[129],"product":[131],"density":[134],"affinity":[136],"available":[138],"receptors).":[139],"Regional":[140],"values":[143,162,188,197],"were":[144,177,189,198],"derived":[145,190],"with":[146,201,227],"three-compartmental":[148],"kinetic":[149],"analysis":[150],"time-activity":[153],"curves":[154],"plasma.":[159],"Binding":[160],"93":[164],"+/-":[165,169,174],"34":[166],"ml/g,":[167],"71":[168],"35":[170],"ml/g":[171,176],"31":[173],"11":[175],"measured":[178],"occipital,":[181],"temporal":[182],"regions,":[185],"respectively.":[186],"Similar":[187],"using":[191],"noncompartmental":[193],"graphical":[194],"analysis.":[195],"These":[196],"accordance":[200],"vitro":[204],"regional":[205],"distribution":[206],"primate":[211],"conclusion,":[214],"allows":[216],"visualization":[217],"quantification":[219],"baboon":[225],"SPECT.":[228]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}