{"id":"https://openalex.org/W2092166405","doi":"https://doi.org/10.1038/nature09087","title":"Presynaptic activity regulates Na+ channel distribution at the axon initial segment","display_name":"Presynaptic activity regulates Na+ channel distribution at the axon initial segment","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2092166405","doi":"https://doi.org/10.1038/nature09087","mag":"2092166405","pmid":"https://pubmed.ncbi.nlm.nih.gov/20543825"},"language":"en","primary_location":{"id":"doi:10.1038/nature09087","doi":"https://doi.org/10.1038/nature09087","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature09087","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041066766","display_name":"Hiroshi Kuba","orcid":"https://orcid.org/0000-0002-9256-2726","observed_orcids":["https://orcid.org/0000-0002-9256-2726"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Kuba","raw_affiliation_strings":["Career-Path Promotion Unit for Young Life Scientists, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. kuba@nbiol.med.kyoto-u.ac.jp","Career-Path Promotion Unit for Young Life Scientists,,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Career-Path Promotion Unit for Young Life Scientists, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. kuba@nbiol.med.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Career-Path Promotion Unit for Young Life Scientists,,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001210158","display_name":"Yuki Oichi","orcid":"https://orcid.org/0000-0002-0225-8158","observed_orcids":["https://orcid.org/0000-0002-0225-8158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuki Oichi","raw_affiliation_strings":["Career-Path Promotion Unit for Young Life Scientists,,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Career-Path Promotion Unit for Young Life Scientists,,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040873940","display_name":"Harunori Ohmori","orcid":"https://orcid.org/0000-0002-4319-4947","observed_orcids":["https://orcid.org/0000-0002-4319-4947"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harunori Ohmori","raw_affiliation_strings":["Department of Physiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan,","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041066766"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":9.5574,"has_fulltext":false,"cited_by_count":445,"citation_normalized_percentile":{"value":0.99060794,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"465","issue":"7301","first_page":"1075","last_page":"1078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.35600000619888306,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axon-initial-segment","display_name":"axon initial segment","score":1.0},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.7820000052452087},{"id":"https://openalex.org/keywords/intrinsic-excitability","display_name":"intrinsic excitability","score":0.7519999742507935},{"id":"https://openalex.org/keywords/auditory-neurons","display_name":"auditory neurons","score":0.49799999594688416},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.8600000143051147},{"id":"https://openalex.org/keywords/homeostatic-plasticity","display_name":"homeostatic plasticity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.7129999995231628},{"id":"https://openalex.org/keywords/presynaptic-activity","display_name":"presynaptic activity","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7900031805038452},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6375276446342468},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.6308963298797607},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6164389848709106},{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.5603865385055542},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5003082752227783},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.4982151985168457},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.48505300283432007},{"id":"https://openalex.org/C2779083617","wikidata":"https://www.wikidata.org/wiki/Q944333","display_name":"Sensory deprivation","level":3,"score":0.46132320165634155},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.44777366518974304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43266069889068604},{"id":"https://openalex.org/C159919123","wikidata":"https://www.wikidata.org/wiki/Q7577157","display_name":"Spike-timing-dependent plasticity","level":4,"score":0.4251651167869568},{"id":"https://openalex.org/C2777918570","wikidata":"https://www.wikidata.org/wiki/Q2423067","display_name":"Axon terminal","level":3,"score":0.4199901223182678},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.3337796926498413},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.13811731338500977},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08785280585289001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001717","descriptor_name":"Birds","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014432","descriptor_name":"Tympanic Membrane","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D050599","descriptor_name":"Vesicular Glutamate Transport Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nature09087","doi":"https://doi.org/10.1038/nature09087","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature09087","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:20543825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20543825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:465:y:2010:i:7301:d:10.1038_nature09087","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature09087","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6393653137","display_name":"Identification of neurons by fluorescence spectrogram through a patch electrode, and the application to auditory neural circuits in vivo","funder_award_id":"20220008","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1482683088","https://openalex.org/W1484837231","https://openalex.org/W1963806203","https://openalex.org/W1965741585","https://openalex.org/W1973967768","https://openalex.org/W1975507486","https://openalex.org/W1982489283","https://openalex.org/W1983158636","https://openalex.org/W1992295484","https://openalex.org/W1992770435","https://openalex.org/W2002812952","https://openalex.org/W2012041126","https://openalex.org/W2013667500","https://openalex.org/W2014501805","https://openalex.org/W2015701831","https://openalex.org/W2036805535","https://openalex.org/W2048635483","https://openalex.org/W2059852978","https://openalex.org/W2065104375","https://openalex.org/W2067951702","https://openalex.org/W2083516287","https://openalex.org/W2093866049","https://openalex.org/W2114309709","https://openalex.org/W2120446671","https://openalex.org/W2122358271","https://openalex.org/W2135945594","https://openalex.org/W2137393514","https://openalex.org/W2147544306","https://openalex.org/W2156541195","https://openalex.org/W2164161545"],"related_works":["https://openalex.org/W1989092549","https://openalex.org/W2778943123","https://openalex.org/W2017612674","https://openalex.org/W7100162096","https://openalex.org/W2538155700","https://openalex.org/W1823090765","https://openalex.org/W2180441594","https://openalex.org/W2346187834","https://openalex.org/W2905460862","https://openalex.org/W1546394398"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":35},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}