{"id":"https://openalex.org/W2092079486","doi":"https://doi.org/10.1172/jci111319","title":"Cleavage of human high molecular weight kininogen markedly enhances its coagulant activity. Evidence that this molecule exists as a procofactor.","display_name":"Cleavage of human high molecular weight kininogen markedly enhances its coagulant activity. Evidence that this molecule exists as a procofactor.","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2092079486","doi":"https://doi.org/10.1172/jci111319","mag":"2092079486","pmid":"https://pubmed.ncbi.nlm.nih.gov/6561202","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/425106"},"language":"en","primary_location":{"id":"doi:10.1172/jci111319","doi":"https://doi.org/10.1172/jci111319","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111319","pdf_url":"http://www.jci.org/articles/view/111319/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/111319/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109438465","display_name":"Cheryl F. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C F Scott","raw_affiliation_strings":["Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I4210122924","https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003868834","display_name":"Lee D. Silver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L D Silver","raw_affiliation_strings":["Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I4210122924","https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008948102","display_name":"Marc Schapira","orcid":"https://orcid.org/0000-0003-0384-0075","observed_orcids":["https://orcid.org/0000-0003-0384-0075"]},"institutions":[{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Schapira","raw_affiliation_strings":["Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I4210122924","https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Colman","raw_affiliation_strings":["Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center and the Hematology/Oncology Section of the Department ofMedicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I4210122924","https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":8.1888,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.98123436,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"73","issue":"4","first_page":"954","last_page":"962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.949999988079071},{"id":"https://openalex.org/keywords/contact-system-activation","display_name":"contact activation","score":0.5450000166893005},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/factor-xii","display_name":"factor XII","score":0.6370000243186951},{"id":"https://openalex.org/keywords/prekallikrein","display_name":"prekallikrein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/factor-xi","display_name":"factor XI","score":0.9750000238418579},{"id":"https://openalex.org/keywords/kaolin-adsorption","display_name":"kaolin adsorption","score":0.824999988079071},{"id":"https://openalex.org/keywords/negatively-charged-surfaces","display_name":"negatively charged surfaces","score":0.7910000085830688},{"id":"https://openalex.org/keywords/protein-adsorption","display_name":"protein adsorption","score":0.5619999766349792},{"id":"https://openalex.org/keywords/contact-system","display_name":"contact system","score":0.4169999957084656},{"id":"https://openalex.org/keywords/kininogen-cleavage","display_name":"kininogen cleavage","score":0.6150000095367432},{"id":"https://openalex.org/keywords/zymogen-activation","display_name":"zymogen activation","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.934361457824707},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.9183464050292969},{"id":"https://openalex.org/C152328610","wikidata":"https://www.wikidata.org/wiki/Q7240014","display_name":"Prekallikrein","level":4,"score":0.8989388942718506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.785351037979126},{"id":"https://openalex.org/C2777167447","wikidata":"https://www.wikidata.org/wiki/Q339499","display_name":"Factor XII","level":3,"score":0.7145743370056152},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5263917446136475},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5209082961082458},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.506930410861969},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.5057296752929688},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5012044906616211},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.4609305262565613},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2721337378025055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17815017700195312},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.058820128440856934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005173","descriptor_name":"Factor XI Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007616","descriptor_name":"Kaolin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007616","descriptor_name":"Kaolin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci111319","doi":"https://doi.org/10.1172/jci111319","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111319","pdf_url":"http://www.jci.org/articles/view/111319/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:425106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/425106","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:6561202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6561202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/67762","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/67762","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_54CBFD13AEE1","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_54CBFD13AEE1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation, vol. 73, no. 4, pp. 954-62","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci111319","doi":"https://doi.org/10.1172/jci111319","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111319","pdf_url":"http://www.jci.org/articles/view/111319/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092079486.pdf","grobid_xml":"https://content.openalex.org/works/W2092079486.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W38611617","https://openalex.org/W153387667","https://openalex.org/W294696112","https://openalex.org/W635228746","https://openalex.org/W1484240548","https://openalex.org/W1527857128","https://openalex.org/W1599155589","https://openalex.org/W1599568592","https://openalex.org/W1606378510","https://openalex.org/W1963680493","https://openalex.org/W1970772713","https://openalex.org/W1976257261","https://openalex.org/W1979886348","https://openalex.org/W1983078238","https://openalex.org/W1985334666","https://openalex.org/W1986074764","https://openalex.org/W1994610964","https://openalex.org/W1996282461","https://openalex.org/W2002983094","https://openalex.org/W2018289835","https://openalex.org/W2025562266","https://openalex.org/W2034405640","https://openalex.org/W2065141688","https://openalex.org/W2069612260","https://openalex.org/W2070598525","https://openalex.org/W2080580789","https://openalex.org/W2089682872","https://openalex.org/W2090238133","https://openalex.org/W2092462079","https://openalex.org/W2100837269","https://openalex.org/W2157488373","https://openalex.org/W2400765833","https://openalex.org/W2405234435","https://openalex.org/W2410684177","https://openalex.org/W2410915991","https://openalex.org/W4251685699"],"related_works":["https://openalex.org/W1996282461","https://openalex.org/W1979886348","https://openalex.org/W2117413916","https://openalex.org/W7098056610","https://openalex.org/W7100295638","https://openalex.org/W2401900277","https://openalex.org/W1986074764","https://openalex.org/W2058162127","https://openalex.org/W2946515129","https://openalex.org/W1985334666"],"abstract_inverted_index":{"High":[0],"molecular":[1],"weight":[2],"kininogen":[3],"(HMW)-kininogen,":[4],"the":[5,12,50,67,94,97,108,115,121,134,142,148,156,163,167,180,232,235,256,260,266,316,328,352,361,405,418,441,457,522,533],"cofactor":[6,511],"of":[7,14,52,56,71,93,96,102,136,150,158,182,234,237,259,262,299,318,324,330,364,385,420,423,444,459,481,509,518,524,530],"contact-activated":[8],"blood":[9],"coagulation,":[10],"accelerates":[11],"activation":[13],"Factor":[15,19,29,44,170,213,268,273,284,448,453,525],"XII,":[16,526],"prekallikrein,":[17],"and":[18,28,46,87,124,215,225,265,275,283,425],"XI":[20,30,269],"on":[21],"a":[22,33,74,209,242,289,388,421,472,479,482,494,498],"negatively":[23,243,290,535],"charged":[24,244,291,536],"surface.":[25,537],"Although":[26],"prekallikrein":[27,216,263],"circulate":[31],"as":[32,81,83,155,193],"complex":[34,294],"with":[35,107,128,141,195,241,295,315,373,383,493,521],"HMW-kininogen,":[36,47,341],"no":[37],"physical":[38],"association":[39,492],"has":[40,49],"been":[41,59],"demonstrated":[42],"between":[43,120],"XII":[45,214],"nor":[48],"order":[51,218],"adsorption":[53,70,149,264,270,323,363,419,520,523],"to":[54,73,152,177,189,221,223,226,239,288,305,339,348,366,378,380,428,433,440,447,462,464,532],"surfaces":[55],"these":[57,279],"proteins":[58,95],"fully":[60,435],"clarified.":[61],"In":[62,145],"this":[63],"report":[64],"we":[65,350],"explore":[66],"requirements":[68],"for":[69,219,360,402,507],"HMW-kininogen":[72,151,168,183,202,220,238,300,325,365,370,427,437,461,470,519],"clot-promoting":[75,495],"surface":[76,245,249,292,496],"(kaolin),":[77],"in":[78,84,91,117,162,169,203,217,247,271,293,327,497],"purified":[79,369,374,445],"systems,":[80],"well":[82],"normal":[85,146,196],"plasma":[86,88,172,186,204,412,499],"genetically":[89],"deficient":[90],"each":[92,103],"contact":[98],"system.":[99],"The":[100,297],"fraction":[101],"coagulant":[104,118,229,301,332],"protein":[105],"associated":[106,140],"kaolin":[109,143,153,159,190,306,345,381,403],"pellet":[110],"was":[111,139,160,191,253,358,371,390,431],"determined":[112],"by":[113,131,208,356,396,477],"measuring":[114],"difference":[116],"activity":[119,302],"initial":[122],"sample":[123],"supernatants":[125],"after":[126,394],"incubation":[127,164],"kaolin,":[129,224,429],"or":[130],"directly":[132],"quantifying":[133],"amount":[135,317],"125I-HMW-kininogen":[137,319],"that":[138,187,201,303,322,354,469,474,504],"pellet.":[144],"plasma,":[147,349,450],"increased":[154,161,382,400],"quantity":[157,181],"mixture.":[165],"However,":[166],"XII-deficient":[171,274,449],"did":[173],"not":[174],"absorb":[175,379],"appreciably":[176],"kaolin.":[178,367,442,465],"Furthermore,":[179,409],"from":[184,255,438],"prekallikrein-deficient":[185],"adsorbed":[188,304],"decreased":[192,248],"compared":[194],"plasma.":[197],"These":[198,466,513],"observations":[199,467],"suggested":[200],"must":[205],"be":[206],"altered":[207],"reaction":[210,483],"involving":[211],"both":[212,272],"adsorb":[222,463],"express":[227],"its":[228,331,376,460,491,510],"activity.":[230,333,512],"Subsequently,":[231],"consequence":[233],"inability":[236],"associate":[240],"results":[246,326],"activation.":[250],"This":[251,487],"assessment":[252],"derived":[254],"further":[257],"observation":[258],"lack":[261],"diminished":[267],"HMW-kininogen-deficient":[276],"plasmas,":[277],"since":[278],"two":[280],"zymogens":[281],"(prekallikrein":[282],"XI)":[285],"are":[286],"transported":[287],"HMW-kininogen.":[296],"percentage":[298],"closely":[307],"correlated":[308],"(r":[309],"=":[310,313],"0.98,":[311],"slope":[312],"0.97)":[314],"adsorbed,":[320],"suggesting":[321],"expression":[329,508],"Since":[334],"kallikrein,":[335,375,397,478],"which":[336,451,484,489,527],"is":[337,342,346,471,475,501,505],"known":[338],"cleave":[340],"generated":[343],"when":[344],"added":[347],"tested":[351],"hypothesis":[353],"proteolysis":[355],"kallikrein":[357,446],"responsible":[359],"enhanced":[362],"When":[368],"incubated":[372],"ability":[377,458],"time":[384],"digestion":[386],"until":[387],"maximum":[389],"reached.":[391],"Moreover,":[392],"(125)I-HMW-kininogen,":[393],"cleavage":[395],"had":[398],"markedly":[399,416],"affinity":[401],"than":[404],"uncleaved":[406,426],"starting":[407],"material.":[408],"fibrinogen,":[410],"at":[411],"concentration":[413],"(3":[414],"mg/ml),":[415],"curtailed":[417],"mixture":[422],"cleaved":[424,436],"but":[430],"unable":[432],"prevent":[434],"adsorbing":[439],"Addition":[443],"bypasses":[452],"XII-dependent":[454],"contact-activation":[455],"amplified":[456],"indicate":[468],"procofactor":[473],"activated":[476],"product":[480],"it":[485],"accelerates.":[486],"cleavage,":[488,531],"enhances":[490],"environment,":[500],"an":[502],"event":[503],"necessary":[506],"interactions":[514],"would":[515],"allow":[516],"coordination":[517],"adsorbs":[528],"independently":[529],"same":[534]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}