{"id":"https://openalex.org/W2092039954","doi":"https://doi.org/10.1038/mt.2014.134","title":"The Profile of Tumor Antigens Which Can be Targeted by Immunotherapy Depends Upon the Tumor's Anatomical Site","display_name":"The Profile of Tumor Antigens Which Can be Targeted by Immunotherapy Depends Upon the Tumor's Anatomical Site","publication_year":2014,"publication_date":"2014-07-25","ids":{"openalex":"https://openalex.org/W2092039954","doi":"https://doi.org/10.1038/mt.2014.134","mag":"2092039954","pmid":"https://pubmed.ncbi.nlm.nih.gov/25059678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4429729"},"language":"en","primary_location":{"id":"doi:10.1038/mt.2014.134","doi":"https://doi.org/10.1038/mt.2014.134","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2014.134","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/mt.2014.134","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013728459","display_name":"Vanesa Alonso-Camino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vanesa Alonso-Camino","raw_affiliation_strings":["Department of Molecular Medicine, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018017760","display_name":"Karishma R. Rajani","orcid":"https://orcid.org/0000-0001-8747-1435","observed_orcids":["https://orcid.org/0000-0001-8747-1435"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karishma Rajani","raw_affiliation_strings":["Department of Molecular Medicine, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002555051","display_name":"Timothy J. Kottke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy Kottke","raw_affiliation_strings":["Department of Molecular Medicine, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091779165","display_name":"Diana M. Rommelfanger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diana Rommelfanger-Konkol","raw_affiliation_strings":["Department of Molecular Medicine, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111696716","display_name":"Shane Zaidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shane Zaidi","raw_affiliation_strings":["1] Department of Molecular Medicine, The Institute of Cancer Research, London, UK [2] The Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, UK","Department of Molecular Medicine, The Institute of Cancer Research, London, UK","The Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Molecular Medicine, The Institute of Cancer Research, London, UK [2] The Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"The Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048427923","display_name":"Jill Thompson","orcid":"https://orcid.org/0000-0001-5005-7257","observed_orcids":["https://orcid.org/0000-0001-5005-7257"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jill Thompson","raw_affiliation_strings":["Department of Molecular Medicine, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082704917","display_name":"Jos\u00e9 S. Pulido","orcid":"https://orcid.org/0000-0003-4804-8962","observed_orcids":["https://orcid.org/0000-0003-4804-8962","https://orcid.org/0000-0003-2009-3163"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Jose Pulido","raw_affiliation_strings":["1] Department of Molecular Medicine, The Institute of Cancer Research, London, UK [2] Department of Ophthalmology and Ocular Oncology Mayo Clinic, Rochester, Minnesota, USA","Department of Molecular Medicine, The Institute of Cancer Research, London, UK","Department of Ophthalmology and Ocular Oncology Mayo Clinic, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Molecular Medicine, The Institute of Cancer Research, London, UK [2] Department of Ophthalmology and Ocular Oncology Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I142947616"]},{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Department of Ophthalmology and Ocular Oncology Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064745768","display_name":"Elizabeth J. Ilett","orcid":"https://orcid.org/0000-0002-9875-0322","observed_orcids":["https://orcid.org/0000-0002-9875-0322"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Ilett","raw_affiliation_strings":["Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012559258","display_name":"Oliver Donnelly","orcid":"https://orcid.org/0000-0001-8613-6686","observed_orcids":["https://orcid.org/0000-0001-8613-6686"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver Donnelly","raw_affiliation_strings":["Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086212361","display_name":"Peter John Selby","orcid":"https://orcid.org/0000-0002-3782-069X","observed_orcids":["https://orcid.org/0000-0002-3782-069X","https://orcid.org/0000-0001-5401-2996","https://orcid.org/0000-0001-9465-9268"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Selby","raw_affiliation_strings":["Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067211956","display_name":"Hardev Pandha","orcid":"https://orcid.org/0000-0002-9420-7701","observed_orcids":["https://orcid.org/0000-0002-9420-7701"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hardev Pandha","raw_affiliation_strings":["Leggett Building, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leggett Building, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069116024","display_name":"Alan A. Melcher","orcid":"https://orcid.org/0000-0002-2042-3380","observed_orcids":["https://orcid.org/0000-0002-2042-3380"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Melcher","raw_affiliation_strings":["Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072284989","display_name":"Kevin Joseph Harrington","orcid":"https://orcid.org/0000-0002-6014-348X","observed_orcids":["https://orcid.org/0000-0002-6014-348X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Harrington","raw_affiliation_strings":["The Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, Division of Cancer Biology, Chester Beatty Laboratories, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109094916","display_name":"Rosa Mar\u00eda D\u00edaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rosa Maria Diaz","raw_affiliation_strings":["Department of Molecular Medicine, The Institute of Cancer Research, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070554485","display_name":"Richard G. Vile","orcid":"https://orcid.org/0000-0003-2192-9372","observed_orcids":["https://orcid.org/0000-0003-2192-9372"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Richard Vile","raw_affiliation_strings":["1] Department of Molecular Medicine, The Institute of Cancer Research, London, UK [2] Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK [3] Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA","Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA","Department of Molecular Medicine, The Institute of Cancer Research, London, UK","Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Molecular Medicine, The Institute of Cancer Research, London, UK [2] Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK [3] Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I142947616"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Medicine, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070554485"],"corresponding_institution_ids":["https://openalex.org/I130828816","https://openalex.org/I1330342723","https://openalex.org/I142947616"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.2677,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78443585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"22","issue":"11","first_page":"1936","last_page":"1948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-antigen-expression","display_name":"tumor antigen expression","score":0.5600000023841858},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.6420000195503235},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.671999990940094},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.546999990940094},{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus","display_name":"vesicular stomatitis virus","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cdna-library","display_name":"cDNA library","score":0.47699999809265137},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.48100000619888306},{"id":"https://openalex.org/keywords/hif-2alpha","display_name":"HIF-2\u03b1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sox10","display_name":"SOX10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9729999899864197},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cd11b-cells","display_name":"CD11b+ cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9750000238418579},{"id":"https://openalex.org/keywords/t-cell-costimulation","display_name":"T cell costimulation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/intracranial-tumors","display_name":"intracranial tumors","score":0.6729999780654907},{"id":"https://openalex.org/keywords/subcutaneous-tumor","display_name":"subcutaneous tumor","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6891336441040039},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5994427800178528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4348573386669159},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.41575315594673157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4062770903110504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35627102851867676},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24705541133880615}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000957","descriptor_name":"Antigens, Viral, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018116","descriptor_name":"Vesiculovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018116","descriptor_name":"Vesiculovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/mt.2014.134","doi":"https://doi.org/10.1038/mt.2014.134","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2014.134","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4429729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4429729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},{"id":"pmid:25059678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25059678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:alma.44SUR_INST:11139956630002346","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=WOS:000337231300512&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=11d2a86992e85fb529977dad66a846d5","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference or Workshop Item"},{"id":"pmh:oai:alma.44SUR_INST:11140088470002346","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&amp;SrcApp=PARTNER_APP&amp;SrcAuth=LinksAMR&amp;KeyUT=WOS:000344429800011&amp;DestLinkType=FullRecord&amp;DestApp=ALL_WOS&amp;UsrCustomerID=11d2a86992e85fb529977dad66a846d5","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:eprints.whiterose.ac.uk:87577","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/87577/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:87580","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/87580/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Proceedings Paper"},{"id":"pmh:oai:epubs.surrey.ac.uk:827081","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/827081/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference or Workshop Item"},{"id":"pmh:oai:epubs.surrey.ac.uk:827859","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/827859/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/mt.2014.134","doi":"https://doi.org/10.1038/mt.2014.134","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2014.134","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1425549394","display_name":null,"funder_award_id":"13244","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G1567379425","display_name":null,"funder_award_id":"CL-2011-22-001","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G1922614325","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0509-10020","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4387789583","display_name":"Immune Cell Carriers for the Delivery of Oncolytic Viruses to Metastatic Tumors","funder_award_id":"R01CA107082","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5454020984","display_name":"Enhancing Systemic Delivery of Oncolytic Viruses for Cancer Therapy","funder_award_id":"R01CA130878","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6610327056","display_name":"Autoimmunity and anti tumor immunity outside of the melanocyte/melanoma paradigm","funder_award_id":"R01CA132734","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7637124021","display_name":"Mayo SPORE in Brain Cancer","funder_award_id":"P50CA108961","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8223580874","display_name":"Enhancing Therapy of Primary and Recurrent Tumors With Systemic Oncolytic Virus","funder_award_id":"R01CA175386","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8878312371","display_name":null,"funder_award_id":"CL-2012-02-002","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G9000866180","display_name":"Mayo Clinic Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA015083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1490163820","https://openalex.org/W1560869084","https://openalex.org/W1967394748","https://openalex.org/W1974620735","https://openalex.org/W1985022658","https://openalex.org/W1985157417","https://openalex.org/W1985577088","https://openalex.org/W1987069333","https://openalex.org/W1988733144","https://openalex.org/W2005654436","https://openalex.org/W2008620560","https://openalex.org/W2010709305","https://openalex.org/W2022397181","https://openalex.org/W2024449289","https://openalex.org/W2035209084","https://openalex.org/W2035442968","https://openalex.org/W2035595523","https://openalex.org/W2037800562","https://openalex.org/W2038304191","https://openalex.org/W2041912362","https://openalex.org/W2048305341","https://openalex.org/W2058016035","https://openalex.org/W2062789111","https://openalex.org/W2064058305","https://openalex.org/W2067956486","https://openalex.org/W2088594694","https://openalex.org/W2089258482","https://openalex.org/W2092585728","https://openalex.org/W2092601545","https://openalex.org/W2093141813","https://openalex.org/W2098772563","https://openalex.org/W2100070517","https://openalex.org/W2115955652","https://openalex.org/W2123863482","https://openalex.org/W2132348448","https://openalex.org/W2137990420","https://openalex.org/W2140111836","https://openalex.org/W2141436943","https://openalex.org/W2141906254","https://openalex.org/W2167034585","https://openalex.org/W2506000649"],"related_works":["https://openalex.org/W2262102254","https://openalex.org/W4244509563","https://openalex.org/W4313385681","https://openalex.org/W2130161641","https://openalex.org/W2946836115","https://openalex.org/W1981080828","https://openalex.org/W4250836231","https://openalex.org/W1987069333","https://openalex.org/W2739850597","https://openalex.org/W4403130244"],"abstract_inverted_index":{"Previously,":[0],"we":[1,37],"showed":[2],"that":[3,39,175,188],"vesicular":[4],"stomatitis":[5],"virus":[6],"(VSV)":[7],"engineered":[8],"to":[9,29],"express":[10],"a":[11,111,180],"cDNA":[12],"library":[13,47],"from":[14,65,122],"human":[15],"melanoma":[16,56],"cells":[17,140,143],"(ASMEL,":[18],"Altered":[19],"Self":[20],"Melanoma":[21],"Epitope":[22],"Library)":[23],"was":[24,48,74,89,135],"an":[25,49],"effective":[26,50,91],"systemic":[27,154],"therapy":[28],"treat":[30],"subcutaneous":[31],"(s.c.)":[32],"murine":[33],"B16":[34,71,78,94,108,132],"melanomas.":[35],"Here,":[36],"show":[38,174],"intravenous":[40],"treatment":[41,51],"with":[42,153,161],"the":[43,66,101,123,138,145,176,184],"same":[44,102],"ASMEL":[45,67,87],"VSV-cDNA":[46,155],"for":[52],"established":[53,162],"intra-cranial":[54],"(i.c.)":[55],"brain":[57,79,95,147],"tumors.":[58,80],"The":[59],"optimal":[60],"combination":[61,83],"of":[62,84,130,159,170,179,186],"antigens":[63,187],"identified":[64],"which":[68,88,119],"treated":[69],"s.c.":[70,131],"tumors":[72,103,109,164],"(VSV-N-RAS+VSV-CYTC-C+VSV-TYRP-1)":[73],"ineffective":[75],"against":[76,92,100],"i.c.":[77,93,107,163],"In":[81],"contrast,":[82],"VSV-expressed":[85],"antigens-VSV-HIF-2\u03b1+VSV-SOX-10+VSV-C-MYC+VSV-TYRP1-from":[86],"highly":[90],"tumors,":[96,133],"had":[97],"no":[98],"efficacy":[99],"growing":[104],"subcutaneously.":[105],"Correspondingly,":[106],"expressed":[110],"HIF-2\u03b1(Hi),":[112],"SOX-10(Hi),":[113],"c-myc(Hi),":[114],"TYRP1,":[115,127],"N-RAS(lo)Cytc(lo)":[116],"antigen":[117],"profile,":[118],"differed":[120],"significantly":[121],"HIF-2\u03b1(lo),":[124],"SOX-10(lo),":[125],"c-myc(lo),":[126],"N-RAS(Hi)Cytc(Hi)":[128],"phenotype":[129],"and":[134],"imposed":[136],"upon":[137],"tumor":[139,148,181],"by":[141],"CD11b(+)":[142],"within":[144],"local":[146],"microenvironment.":[149],"Combining":[150],"T-cell":[151],"costimulation":[152],"treatment,":[156],"long-term":[157],"cures":[158],"mice":[160],"were":[165],"achieved":[166],"in":[167],"about":[168],"75%":[169],"mice.":[171],"Our":[172],"data":[173],"anatomical":[177],"location":[178],"profoundly":[182],"affects":[183],"profile":[185],"it":[189],"expresses.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
