{"id":"https://openalex.org/W2092004124","doi":"https://doi.org/10.1210/mend.14.10.0542","title":"Tumor Necrosis Factor \u03b1-Mediated Insulin Resistance, but Not Dedifferentiation, Is Abrogated by MEK1/2 Inhibitors in 3T3-L1 Adipocytes","display_name":"Tumor Necrosis Factor \u03b1-Mediated Insulin Resistance, but Not Dedifferentiation, Is Abrogated by MEK1/2 Inhibitors in 3T3-L1 Adipocytes","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2092004124","doi":"https://doi.org/10.1210/mend.14.10.0542","mag":"2092004124","pmid":"https://pubmed.ncbi.nlm.nih.gov/11043572"},"language":"en","primary_location":{"id":"doi:10.1210/mend.14.10.0542","doi":"https://doi.org/10.1210/mend.14.10.0542","is_oa":true,"landing_page_url":"https://doi.org/10.1210/mend.14.10.0542","pdf_url":"https://academic.oup.com/mend/article-pdf/14/10/1557/8946910/mend1557.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mend/article-pdf/14/10/1557/8946910/mend1557.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040093136","display_name":"Jeffrey A. Engelman","orcid":"https://orcid.org/0009-0004-0775-4523","observed_orcids":["https://orcid.org/0009-0004-0775-4523"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Engelman","raw_affiliation_strings":["Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461","Department of Molecular Pharmacology and Diabetes Research and Training Center (J.A.E., M.P.L.) Albert Einstein College of Medicine Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Diabetes Research and Training Center (J.A.E., M.P.L.) Albert Einstein College of Medicine Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028559337","display_name":"Anders Hayden Berg","orcid":"https://orcid.org/0000-0002-5736-0686","observed_orcids":["https://orcid.org/0000-0002-5736-0686"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders H. Berg","raw_affiliation_strings":["Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065508725","display_name":"Ren\u00e9e Y. Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rene\u0301e Y. Lewis","raw_affiliation_strings":["Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016681558","display_name":"Michael P. Lisanti","orcid":"https://orcid.org/0000-0003-2034-1382","observed_orcids":["https://orcid.org/0000-0003-2034-1382"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Lisanti","raw_affiliation_strings":["Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461","Department of Molecular Pharmacology and Diabetes Research and Training Center (J.A.E., M.P.L.) Albert Einstein College of Medicine Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Diabetes Research and Training Center (J.A.E., M.P.L.) Albert Einstein College of Medicine Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077747436","display_name":"Philipp E. Scherer","orcid":"https://orcid.org/0000-0003-0680-3392","observed_orcids":["https://orcid.org/0000-0003-0680-3392"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philipp E. Scherer","raw_affiliation_strings":["Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Diabetes Research and Training Center (A.H.B., R.Y.L., P.E.S.) Albert Einstein College of Medicine Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077747436"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":4.0086,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.93416073,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"10","first_page":"1557","last_page":"1569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/irs-1-serine-phosphorylation","display_name":"IRS-1 serine phosphorylation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/adipocyte-dedifferentiation","display_name":"adipocyte dedifferentiation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7009999752044678},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9009193181991577},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7615038156509399},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6558597087860107},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.530860960483551},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4653955399990082},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45427167415618896},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4417990744113922},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4384698271751404},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4372081160545349},{"id":"https://openalex.org/C142536801","wikidata":"https://www.wikidata.org/wiki/Q4636414","display_name":"3T3-L1","level":4,"score":0.43303343653678894},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40026646852493286},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.3080388009548187},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2365221083164215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10144633054733276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010768","descriptor_name":"Phosphoserine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048370","descriptor_name":"MAP Kinase Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/mend.14.10.0542","doi":"https://doi.org/10.1210/mend.14.10.0542","is_oa":true,"landing_page_url":"https://doi.org/10.1210/mend.14.10.0542","pdf_url":"https://academic.oup.com/mend/article-pdf/14/10/1557/8946910/mend1557.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:11043572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11043572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/mend.14.10.0542","doi":"https://doi.org/10.1210/mend.14.10.0542","is_oa":true,"landing_page_url":"https://doi.org/10.1210/mend.14.10.0542","pdf_url":"https://academic.oup.com/mend/article-pdf/14/10/1557/8946910/mend1557.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9451000094413757}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1452006332","display_name":null,"funder_award_id":"T32-GM-07491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2460367380","display_name":null,"funder_award_id":"T32GM07288","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G250219296","display_name":null,"funder_award_id":"1R01-DK55758","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3386465620","display_name":null,"funder_award_id":"R01CA80250","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G414603534","display_name":null,"funder_award_id":"DK 55758","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4423925290","display_name":null,"funder_award_id":"T32-GM07288","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6095495639","display_name":"Adiponectin, A Protein Secreted From Adipose Tissue","funder_award_id":"R01DK055758","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7764720279","display_name":"Training Program in Cellular and Molecular Biology and Genetics","funder_award_id":"T32GM007491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G87033130","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007288","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8971120136","display_name":null,"funder_award_id":"CA-80250","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320308949","display_name":"Sidney Kimmel Foundation for Cancer Research","ror":"https://ror.org/00wdspp82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092004124.pdf","grobid_xml":"https://content.openalex.org/works/W2092004124.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W90761774","https://openalex.org/W1528493806","https://openalex.org/W1551443142","https://openalex.org/W1570362997","https://openalex.org/W1572009433","https://openalex.org/W1591823948","https://openalex.org/W1605681980","https://openalex.org/W1764140709","https://openalex.org/W1923643609","https://openalex.org/W1968805130","https://openalex.org/W1971762417","https://openalex.org/W1974159373","https://openalex.org/W1975299036","https://openalex.org/W1977669473","https://openalex.org/W1984633752","https://openalex.org/W1988870963","https://openalex.org/W1997030207","https://openalex.org/W2003659422","https://openalex.org/W2009818179","https://openalex.org/W2022801078","https://openalex.org/W2022930571","https://openalex.org/W2040245081","https://openalex.org/W2041130899","https://openalex.org/W2045726368","https://openalex.org/W2046053482","https://openalex.org/W2053200285","https://openalex.org/W2059895279","https://openalex.org/W2061046384","https://openalex.org/W2062552463","https://openalex.org/W2066569500","https://openalex.org/W2075326322","https://openalex.org/W2086262311","https://openalex.org/W2098542111","https://openalex.org/W2102683312","https://openalex.org/W2129316761","https://openalex.org/W2140793658","https://openalex.org/W2147825853","https://openalex.org/W2155437852","https://openalex.org/W2174322658","https://openalex.org/W2342149286"],"related_works":["https://openalex.org/W2095021139","https://openalex.org/W1988870963","https://openalex.org/W2156696618","https://openalex.org/W2035129691","https://openalex.org/W1968805130","https://openalex.org/W2098542111","https://openalex.org/W2002006853","https://openalex.org/W2022930571","https://openalex.org/W2049215243","https://openalex.org/W3150003378"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor-alpha":[2],"(TNFalpha)":[3],"has":[4],"been":[5],"implicated":[6],"as":[7,19,224],"a":[8,130,193,201],"contributing":[9],"mediator":[10],"of":[11,38,53,75,93,113,152,195,204,211,229,233],"insulin":[12,33,42,105,137,185,257],"resistance":[13,34,186],"observed":[14,166],"in":[15,65,68,154],"pathophysiological":[16],"conditions":[17],"such":[18],"obesity,":[20],"cancer-induced":[21],"cachexia,":[22],"and":[23,70,184,231],"bacterial":[24],"infections.":[25],"Previous":[26],"studies":[27],"have":[28],"demonstrated":[29],"that":[30,77,90,118,141,238,255],"TNFalpha":[31,142,158,216],"confers":[32],"by":[35,132,207,226,265],"promoting":[36],"phosphorylation":[37,52,151,183,203],"serine":[39,83,126,182],"residues":[40],"on":[41],"receptor":[43],"substrate":[44],"1":[45],"(IRS-1),":[46],"thereby":[47,128],"diminishing":[48],"subsequent":[49],"insulin-induced":[50],"tyrosine":[51,150],"IRS-1.":[54],"However,":[55],"little":[56],"is":[57,121,165,263],"known":[58],"about":[59,71],"which":[60,133],"signaling":[61,106],"molecules":[62],"are":[63,187],"involved":[64],"this":[66,86,239],"process":[67],"adipocytes":[69],"the":[72,94,111,208,227,266],"temporal":[73],"sequence":[74],"events":[76],"ultimately":[78],"leads":[79],"to":[80,107,146,176],"TNFalpha-stimulated":[81],"IRS-1":[82,125,153,181,205],"phosphorylation.":[84],"In":[85],"study,":[87],"we":[88],"demonstrate":[89],"specific":[91],"inhibitors":[92,135],"MAP":[95,161,248,268],"kinase":[96,97,102,269],"(MEK)1/2-p42/44":[98],"mitogen-activated":[99],"protein":[100],"(MAP)":[101],"pathway":[103],"restore":[104,136],"normal":[108],"levels":[109,178],"despite":[110],"presence":[112],"TNFalpha.":[114],"Additional":[115],"experiments":[116],"show":[117],"MEK1/2":[119],"activity":[120,174],"required":[122],"for":[123],"TNFalpha-induced":[124,212],"phosphorylation,":[127],"suggesting":[129],"mechanism":[131,194],"these":[134],"signaling.":[138],"We":[139,236],"observe":[140,237],"requires":[143],"2.5-4":[144],"h":[145],"markedly":[147],"reduce":[148],"insulin-triggered":[149],"3T3-L1":[155],"adipocytes.":[156],"Although":[157],"activates":[159],"p42/44":[160,173,196,213,247],"kinase,":[162],"maximal":[163],"stimulation":[164],"within":[167],"10-30":[168],"min.":[169],"To":[170],"our":[171],"surprise,":[172],"returns":[175],"basal":[177],"well":[179],"before":[180],"observed.":[188],"These":[189],"activation":[190],"kinetics":[191],"suggest":[192],"action":[197],"more":[198],"complicated":[199],"than":[200],"direct":[202],"triggered":[206],"early":[209],"spike":[210],"activity.":[214],"Chronic":[215],"treatment":[217],"(>>":[218],"72":[219],"h)":[220],"causes":[221],"adipocyte":[222,261],"dedifferentiation,":[223,262],"evidenced":[225],"loss":[228],"triglycerides":[230],"down-regulation":[232],"adipocyte-specific":[234],"markers.":[235],"longer":[240],"term":[241],"TNFalpha-mediated":[242,256],"dedifferentiation":[243],"effect":[244],"utilizes":[245],"alternative,":[246],"kinase-independent":[249],"intracellular":[250],"pathways.":[251],"This":[252],"study":[253],"suggests":[254],"resistance,":[258],"but":[259],"not":[260],"mediated":[264],"MEK1/2-p42/44":[267],"pathway.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}