{"id":"https://openalex.org/W2091990304","doi":"https://doi.org/10.1097/ajp.0b013e318159f94a","title":"Mirtazapine Decreases the Pain Feeling in Healthy Participants","display_name":"Mirtazapine Decreases the Pain Feeling in Healthy Participants","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W2091990304","doi":"https://doi.org/10.1097/ajp.0b013e318159f94a","mag":"2091990304","pmid":"https://pubmed.ncbi.nlm.nih.gov/18209516"},"language":"en","primary_location":{"id":"doi:10.1097/ajp.0b013e318159f94a","doi":"https://doi.org/10.1097/ajp.0b013e318159f94a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ajp.0b013e318159f94a","pdf_url":null,"source":{"id":"https://openalex.org/S102460418","display_name":"Clinical Journal of Pain","issn_l":"0749-8047","issn":["0749-8047","1536-5409"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical Journal of Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110149118","display_name":"Pierre Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210115126","display_name":"H\u00f4pital Orthop\u00e9dique de la Suisse Romande","ror":"https://ror.org/022vd9g66","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]},{"id":"https://openalex.org/I4210165539","display_name":"Clinique Romande de R\u00e9adaptation","ror":"https://ror.org/05kz5x194","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210165539"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Pierre Arnold","raw_affiliation_strings":["Service de r\u00e9adaptation neurologique Clinique romande de r\u00e9adaptation SuvaCare, Sion, Switzerland. pierre.arnold@crr-suva.ch","Service de neurologie, CHUV, Lausanne, Switzerland","Service de r\u00e9adaptation neurologique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de r\u00e9adaptation neurologique Clinique romande de r\u00e9adaptation SuvaCare, Sion, Switzerland. pierre.arnold@crr-suva.ch","institution_ids":["https://openalex.org/I4210165539"]},{"raw_affiliation_string":"Service de neurologie, CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]},{"raw_affiliation_string":"Service de r\u00e9adaptation neurologique","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109278796","display_name":"Philippe Vuadens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210115126","display_name":"H\u00f4pital Orthop\u00e9dique de la Suisse Romande","ror":"https://ror.org/022vd9g66","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Philippe Vuadens","raw_affiliation_strings":["Service de neurologie, CHUV, Lausanne, Switzerland","Service de r\u00e9adaptation neurologique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie, CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]},{"raw_affiliation_string":"Service de r\u00e9adaptation neurologique","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032536875","display_name":"Thierry K\u00fcntzer","orcid":"https://orcid.org/0000-0002-7788-1673","observed_orcids":["https://orcid.org/0000-0002-7788-1673"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210115126","display_name":"H\u00f4pital Orthop\u00e9dique de la Suisse Romande","ror":"https://ror.org/022vd9g66","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thierry Kuntzer","raw_affiliation_strings":["Service de neurologie, CHUV, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de neurologie, CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086524670","display_name":"Charles Gobelet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Gobelet","raw_affiliation_strings":["Service de r\u00e9adaptation g\u00e9n\u00e9rale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de r\u00e9adaptation g\u00e9n\u00e9rale","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040645048","display_name":"O. D\u00e9riaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165539","display_name":"Clinique Romande de R\u00e9adaptation","ror":"https://ror.org/05kz5x194","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210165539"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Olivier Deriaz","raw_affiliation_strings":["Service de recherche, Clinique romande de r\u00e9adaptation SuvaCare, Sion"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de recherche, Clinique romande de r\u00e9adaptation SuvaCare, Sion","institution_ids":["https://openalex.org/I4210165539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109278796","https://openalex.org/A5110149118"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I4210115126","https://openalex.org/I4210165539"],"apc_list":null,"apc_paid":null,"fwci":2.2561,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.86938003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"2","first_page":"116","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mirtazapine","display_name":"mirtazapine","score":1.0},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.925000011920929},{"id":"https://openalex.org/keywords/pain-threshold","display_name":"pain threshold","score":0.8069999814033508},{"id":"https://openalex.org/keywords/nociceptive-flexion-reflex","display_name":"nociceptive flexion reflex","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pain-tolerance","display_name":"pain tolerance","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9829999804496765},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2781068410","wikidata":"https://www.wikidata.org/wiki/Q421930","display_name":"Mirtazapine","level":4,"score":0.928768515586853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7636246085166931},{"id":"https://openalex.org/C122980154","wikidata":"https://www.wikidata.org/wiki/Q205555","display_name":"Feeling","level":2,"score":0.6427794098854065},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.40571844577789307},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.35725343227386475},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3396282494068146},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19320818781852722},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.12369447946548462},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.08033564686775208}],"mesh":[{"descriptor_ui":"D000078785","descriptor_name":"Mirtazapine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015990","descriptor_name":"Placebo Effect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/ajp.0b013e318159f94a","doi":"https://doi.org/10.1097/ajp.0b013e318159f94a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ajp.0b013e318159f94a","pdf_url":null,"source":{"id":"https://openalex.org/S102460418","display_name":"Clinical Journal of Pain","issn_l":"0749-8047","issn":["0749-8047","1536-5409"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical Journal of Pain","raw_type":"journal-article"},{"id":"pmid:18209516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18209516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical journal of pain","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/151939","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/151939","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_93E3F9BEF96A","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_93E3F9BEF96A","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Journal of Pain, vol. 24, no. 2, pp. 116-119","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W82552939","https://openalex.org/W105370144","https://openalex.org/W1555993468","https://openalex.org/W1966421650","https://openalex.org/W1969040411","https://openalex.org/W1970290447","https://openalex.org/W1975010485","https://openalex.org/W1989694732","https://openalex.org/W1996605546","https://openalex.org/W2002543001","https://openalex.org/W2008398707","https://openalex.org/W2009568727","https://openalex.org/W2026862422","https://openalex.org/W2030142338","https://openalex.org/W2039324822","https://openalex.org/W2055421991","https://openalex.org/W2057621238","https://openalex.org/W2061178662","https://openalex.org/W2131474000","https://openalex.org/W2138407894","https://openalex.org/W2143538143","https://openalex.org/W2155212844","https://openalex.org/W2159865397","https://openalex.org/W2162304282","https://openalex.org/W4250657420"],"related_works":["https://openalex.org/W3010205415","https://openalex.org/W2181638459","https://openalex.org/W1965544203","https://openalex.org/W2029606206","https://openalex.org/W2564827945","https://openalex.org/W2736886179","https://openalex.org/W2314294614","https://openalex.org/W2033108153","https://openalex.org/W2161277655","https://openalex.org/W2002867897"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,47,71,88,106,145,163],"treatment":[2],"of":[3,25,49,90,117,148,174],"neuropathic":[4,160],"pain":[5,60,85,140,152,161],"is":[6,29],"mainly":[7],"based":[8],"on":[9,97,151],"antiepileptics,":[10],"tricyclic":[11,34],"antidepressants,":[12],"and":[13,32,39],"opiates.":[14],"These":[15],"drugs":[16],"have":[17],"important":[18],"side":[19],"effects":[20],"disturbing":[21],"the":[22,59,84,110,139,172],"patient's":[23],"quality":[24],"life.":[26],"Mirtazapine":[27],"(MTZ)":[28],"a":[30,63,102,113],"new":[31],"well-tolerated":[33],"antidepressants":[35],"with":[36],"both":[37],"monoaminergic":[38],"opioid":[40],"properties":[41],"that":[42],"might":[43,165],"favorably":[44],"influence":[45],"pain.":[46],"aim":[48],"this":[50,149],"study":[51],"was":[52,80,95,108,134],"to":[53,67,76,82,93],"assess":[54],"whether":[55],"MTZ":[56,91,137],"can":[57],"reduce":[58],"induced":[61],"by":[62],"standardized":[64],"stimulus":[65,79],"presented":[66],"healthy":[68,99,143],"human":[69],"participants.":[70,144],"nociceptive":[72],"flexion":[73],"reflex":[74],"(NFR)":[75],"an":[77,168],"electric":[78],"chosen":[81],"determine":[83],"threshold.":[86],"METHODS:":[87],"effect":[89,150],"compared":[92],"placebo":[94],"assessed":[96],"10":[98],"participants":[100],"in":[101,127,142,158],"double-blinded":[103],"cross-over":[104],"design.":[105],"NFR":[107,132,164],"measured":[109],"day":[111],"after":[112],"single":[114],"oral":[115],"dose":[116],"drug":[118],"(30":[119],"mg)":[120],"or":[121],"placebo.":[122],"RESULTS:":[123],"A":[124],"significant":[125],"increase":[126],"upper":[128],"limb":[129],"(+29%,":[130],"P=0.006)":[131],"threshold":[133],"observed.":[135],"DISCUSSION:":[136],"increases":[138],"tolerance":[141],"potential":[146],"benefit":[147],"should":[153],"be":[154],"investigated":[155],"more":[156],"thoroughly":[157],"chronic":[159],"patients.":[162,176],"serve":[166],"as":[167],"additional":[169],"tool":[170],"for":[171],"monitoring":[173],"these":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}