{"id":"https://openalex.org/W2091948231","doi":"https://doi.org/10.1117/12.2079549","title":"Optical cryoimaging of rat kidney and the effective role of chromosome 13 in salt-induced hypertension","display_name":"Optical cryoimaging of rat kidney and the effective role of chromosome 13 in salt-induced hypertension","publication_year":2015,"publication_date":"2015-03-05","ids":{"openalex":"https://openalex.org/W2091948231","doi":"https://doi.org/10.1117/12.2079549","mag":"2091948231"},"language":"en","primary_location":{"id":"doi:10.1117/12.2079549","doi":"https://doi.org/10.1117/12.2079549","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2079549","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064328823","display_name":"Fahimeh Salehpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Salehpour","raw_affiliation_strings":["Univ. of Wisconsin-Milwaukee, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin-Milwaukee, United States","institution_ids":["https://openalex.org/I43579087"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Yang","raw_affiliation_strings":["Medical College of Wisconsin, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Kurth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Kurth","raw_affiliation_strings":["Medical College of Wisconsin, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071829883","display_name":"Allen W. Cowley","orcid":"https://orcid.org/0000-0002-0801-6248","observed_orcids":["https://orcid.org/0000-0002-0801-6248"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. W. Cowley","raw_affiliation_strings":["Medical College of Wisconsin, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073960891","display_name":"Mahsa Ranji","orcid":"https://orcid.org/0000-0002-4185-5676","observed_orcids":["https://orcid.org/0000-0002-4185-5676"]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ranji","raw_affiliation_strings":["Univ. of Wisconsin-Milwaukee, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin-Milwaukee, United States","institution_ids":["https://openalex.org/I43579087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6319,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.81482296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9321","issue":null,"first_page":"932113","last_page":"932113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.4390000104904175,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.4390000104904175,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salt-induced-hypertension","display_name":"salt-induced hypertension","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dahl-salt-sensitive-rats","display_name":"Dahl salt-sensitive rats","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chromosome-13","display_name":"chromosome 13","score":0.8190000057220459},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6830000281333923},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.7429999709129333},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8690186738967896},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.6068682074546814},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5380434989929199},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5318652391433716},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5003025531768799},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4632694721221924},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.43247461318969727},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4316957890987396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4188893437385559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.394855260848999},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39142346382141113},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38260316848754883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3258313834667206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26051217317581177},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.07441496849060059},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2079549","doi":"https://doi.org/10.1117/12.2079549","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2079549","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1562365376","https://openalex.org/W2038458733","https://openalex.org/W2039642614","https://openalex.org/W2057849674","https://openalex.org/W2078593792","https://openalex.org/W2099273954","https://openalex.org/W2102659881","https://openalex.org/W2134819303","https://openalex.org/W2139901749","https://openalex.org/W2140211254","https://openalex.org/W2145934893","https://openalex.org/W2153089557","https://openalex.org/W2156312824","https://openalex.org/W2166838509","https://openalex.org/W4243772264"],"related_works":["https://openalex.org/W2014143042","https://openalex.org/W4297915848","https://openalex.org/W21714314","https://openalex.org/W2397129096","https://openalex.org/W3084225758","https://openalex.org/W2519812382","https://openalex.org/W50887041","https://openalex.org/W2039642614","https://openalex.org/W1966199110","https://openalex.org/W2351193485"],"abstract_inverted_index":{"The":[0,42,124],"objective":[1],"of":[2,50,83,100,134,146,149],"this":[3],"work":[4],"is":[5],"to":[6,20,137,140],"assess":[7],"oxidative":[8,102,147,156],"stress":[9,103,148,157],"levels":[10,158],"in":[11,104,115,130,143,165],"salt-sensitive":[12,60],"hypertension":[13],"animal":[14],"model":[15],"using":[16],"3D":[17],"optical":[18],"cryoimager":[19],"image":[21],"mitochondrial":[22,131,163],"redox":[23,90,132,164],"ratio.":[24],"We":[25],"studied":[26],"Dahl":[27],"salt-induced":[28],"(SS)":[29,61],"rats,":[30],"and":[31,64,111,159],"compared":[32,136],"the":[33,48,53,59,101,144,150,153],"results":[34,154],"with":[35],"a":[36,79,97,127],"consomic":[37],"SS":[38,135],"rat":[39,57],"strain":[40,44],"(SSBN13).":[41],"SSBN13":[43,138],"was":[45,94],"developed":[46],"by":[47],"introgression":[49],"chromosome":[51],"from":[52,68,120],"Brown":[54],"Norway":[55],"(BN)":[56],"into":[58],"genetic":[62],"background":[63],"exhibits":[65],"significant":[66],"protection":[67],"salt":[69,81,166],"induced":[70],"hypertension1":[71],".":[72],"These":[73],"two":[74],"groups":[75],"were":[76,118],"fed":[77],"on":[78,162],"high":[80],"diet":[82],"8.0%":[84],"NaCl":[85],"for":[86],"one":[87],"week.":[88],"Mitochondrial":[89],"ratio":[91,133],"(NADH/FAD=NADH":[92],"RR),":[93],"used":[95],"as":[96],"quantitative":[98],"marker":[99],"kidney":[105,122],"tissue.":[106,151],"Maximum":[107],"intensity":[108],"projected":[109],"images":[110],"their":[112],"corresponding":[113],"histograms":[114],"each":[116,121],"group":[117],"acquired":[119],"group.":[123],"result":[125],"showed":[126],"49%":[128],"decrease":[129],"translated":[139],"an":[141],"increase":[142],"level":[145],"Therefore,":[152],"quantify":[155],"its":[160],"effect":[161],"sensitive":[167],"hypertension.":[168]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}