{"id":"https://openalex.org/W2091870640","doi":"https://doi.org/10.1074/jbc.271.29.17226","title":"Site-directed Mutagenesis of Glycine 99 to Alanine in L-Lactate Monooxygenase from","display_name":"Site-directed Mutagenesis of Glycine 99 to Alanine in L-Lactate Monooxygenase from","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2091870640","doi":"https://doi.org/10.1074/jbc.271.29.17226","mag":"2091870640","pmid":"https://pubmed.ncbi.nlm.nih.gov/8663383"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.271.29.17226","doi":"https://doi.org/10.1074/jbc.271.29.17226","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.29.17226","pdf_url":"http://www.jbc.org/article/S002192581831322X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581831322X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022261026","display_name":"Weimei Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weimei Sun","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606, USA","\u2021 Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"\u2021 Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606 and the","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089196941","display_name":"Charles H. Williams","orcid":"https://orcid.org/0000-0002-0331-5652","observed_orcids":["https://orcid.org/0000-0002-0331-5652"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210122509","display_name":"Ann Arbor VA Medical Center","ror":"https://ror.org/039n0s143","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210122509","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles H. Williams","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48105","\u2021 Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48105","institution_ids":["https://openalex.org/I4210122509"]},{"raw_affiliation_string":"\u2021 Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606 and the","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079221179","display_name":"Vincent Massey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vincent Massey","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0606 and the","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079221179"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9193,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71190658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"271","issue":"29","first_page":"17226","last_page":"17233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.925000011920929},{"id":"https://openalex.org/keywords/pyruvate-oxidation","display_name":"pyruvate oxidation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/oxidative-decarboxylation","display_name":"oxidative decarboxylation","score":0.828000009059906},{"id":"https://openalex.org/keywords/l-lactate-oxidase","display_name":"L-lactate oxidase","score":0.796999990940094},{"id":"https://openalex.org/keywords/oxygen-reactivity","display_name":"oxygen reactivity","score":0.878000020980835},{"id":"https://openalex.org/keywords/steric-hindrance","display_name":"steric hindrance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hydrogen-peroxide-production","display_name":"hydrogen peroxide production","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.8056647777557373},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.7882440090179443},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6453046202659607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6062418818473816},{"id":"https://openalex.org/C103408237","wikidata":"https://www.wikidata.org/wiki/Q2642668","display_name":"Site-directed mutagenesis","level":4,"score":0.6023901104927063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49961137771606445},{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.4825860559940338},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2764085531234741},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.17652738094329834},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1614917516708374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1270809769630432},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010070","descriptor_name":"Oxalates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.271.29.17226","doi":"https://doi.org/10.1074/jbc.271.29.17226","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.29.17226","pdf_url":"http://www.jbc.org/article/S002192581831322X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8663383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8663383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.271.29.17226","doi":"https://doi.org/10.1074/jbc.271.29.17226","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.29.17226","pdf_url":"http://www.jbc.org/article/S002192581831322X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2569404856","display_name":null,"funder_award_id":"GM21444","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2869093499","display_name":null,"funder_award_id":"GM11106","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091870640.pdf","grobid_xml":"https://content.openalex.org/works/W2091870640.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1487272172","https://openalex.org/W1497916245","https://openalex.org/W1502554469","https://openalex.org/W1507190190","https://openalex.org/W1507208022","https://openalex.org/W1511235644","https://openalex.org/W1513416677","https://openalex.org/W1523408240","https://openalex.org/W1526638050","https://openalex.org/W1549887344","https://openalex.org/W1570548591","https://openalex.org/W1575978929","https://openalex.org/W1590795483","https://openalex.org/W1593953517","https://openalex.org/W1785060582","https://openalex.org/W1828414421","https://openalex.org/W1970801696","https://openalex.org/W1978330219","https://openalex.org/W1979437065","https://openalex.org/W1996811682","https://openalex.org/W2003289340","https://openalex.org/W2017807287","https://openalex.org/W2047131411","https://openalex.org/W2054943036","https://openalex.org/W2065314019","https://openalex.org/W2067722023","https://openalex.org/W2082415864","https://openalex.org/W2100837269","https://openalex.org/W2102626637","https://openalex.org/W2120113652","https://openalex.org/W2131342998","https://openalex.org/W2133574204","https://openalex.org/W2160559912","https://openalex.org/W2253374603","https://openalex.org/W2292927483","https://openalex.org/W2735482738","https://openalex.org/W2943599419","https://openalex.org/W4285826988"],"related_works":["https://openalex.org/W2007359091","https://openalex.org/W2019119244","https://openalex.org/W1511235644","https://openalex.org/W2093397742","https://openalex.org/W629369887","https://openalex.org/W2895441549","https://openalex.org/W1502554469","https://openalex.org/W1487272172","https://openalex.org/W2092244503","https://openalex.org/W194069287"],"abstract_inverted_index":{"L-Lactate":[0],"monooxygenase":[1,226],"(LMO)":[2],"from":[3,223],"Mycobacterium":[4],"smegmatis":[5],"was":[6,30],"mutated":[7],"at":[8,96,147,164],"glycine":[9,39],"99":[10],"to":[11,21,32,59,78,90,100,110,118,175,190,196,228],"alanine,":[12],"and":[13,62,157,198,206,214,274],"the":[14,17,34,37,42,45,60,68,82,103,119,138,154,171,176,182,192,208,218,221,250,257,264,268,272,280],"properties":[15],"of":[16,28,44,49,65,74,81,102,108,125,181,194,202,212,256,271,289],"resulting":[18],"mutant":[19],"(referred":[20],"as":[22],"G99A)":[23],"were":[24],"studied.":[25],"Mutant":[26],"G99A":[27,86,112,130,143,160,186,237],"LMO":[29,53,75],"designed":[31],"test":[33],"postulate":[35],"that":[36,101,117,129,249,276],"smaller":[38],"residue":[40],"in":[41,51,67,76,263,267,279],"vicinity":[43],"alpha-carbon":[46],"methyl":[47],"group":[48],"lactate":[50],"wild-type":[52,104,120,139,155,172],"has":[54,87,131,187,238],"less":[55],"steric":[56,252],"hindrance,":[57],"leading":[58],"retention":[61],"oxidative":[63],"decarboxylation":[64,210],"pyruvate":[66,109,197,213],"active":[69,281],"site,":[70],"a":[71,97,132,148,165,239,260],"unique":[72],"property":[73],"contrast":[77],"other":[79],"members":[80],"FMN-dependent":[83],"oxidase/dehydrogenase":[84],"family.":[85],"been":[88,188],"shown":[89,189],"be":[91],"readily":[92],"reduced":[93,111,142,159,184],"by":[94],"L-lactate":[95,195,225,229,235],"rate":[98,149,166],"similar":[99],"enzyme.":[105,121,140,173],"The":[106],"binding":[107],"is":[113,128],"4-fold":[114],"weaker":[115],"than":[116,137,153,170],"A":[122],"dramatic":[123],"change":[124,253,262],"this":[126],"mutation":[127,219],"much":[133,240],"lower":[134,241],"oxygen":[135,179],"reactivity":[136,180,242],"Pyruvate-bound":[141],"reacts":[144,161],"with":[145,162,234],"O2":[146,163,290],"approximately":[150,167],"10(5)-fold":[151],"slower":[152,169],"enzyme,":[156,185],"free":[158],"100-fold":[168],"Due":[174],"very":[177],"low":[178],"pyruvate-bound":[183],"catalyze":[191],"oxidation":[193],"hydrogen":[199,215],"peroxide":[200],"instead":[201],"acetate,":[203],"carbon":[204],"dioxide,":[205],"water,":[207],"normal":[209],"products":[211],"peroxide.":[216],"Thus,":[217],"alters":[220],"enzyme":[222,273],"its":[224],"activity":[227],"oxidase":[230],"activity.":[231],"However,":[232],"compared":[233],"oxidase,":[236],"toward":[243],"oxygen.":[244],"Our":[245],"results":[246],"also":[247],"reveal":[248],"small":[251],"around":[254],"N-5":[255],"flavin":[258],"causes":[259],"profound":[261],"electronic":[265],"distribution":[266],"catalytic":[269],"cavity":[270],"imply":[275],"electrostatic":[277],"interactions":[278],"site":[282],"provide":[283],"an":[284],"important":[285],"factor":[286],"for":[287],"control":[288],"reactivity.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
