{"id":"https://openalex.org/W2091823971","doi":"https://doi.org/10.1007/s12522-014-0191-3","title":"Effects of Hachimijiogan, a Kampo powder, on epididymidis sperm characteristics in healthy male rats","display_name":"Effects of Hachimijiogan, a Kampo powder, on epididymidis sperm characteristics in healthy male rats","publication_year":2014,"publication_date":"2014-08-14","ids":{"openalex":"https://openalex.org/W2091823971","doi":"https://doi.org/10.1007/s12522-014-0191-3","mag":"2091823971","pmid":"https://pubmed.ncbi.nlm.nih.gov/29259400","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5715816"},"language":"en","primary_location":{"id":"doi:10.1007/s12522-014-0191-3","doi":"https://doi.org/10.1007/s12522-014-0191-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12522-014-0191-3","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-014-0191-3","source":{"id":"https://openalex.org/S86486980","display_name":"Reproductive Medicine and Biology","issn_l":"1445-5781","issn":["1445-5781","1447-0578"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Medicine and Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-014-0191-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108049403","display_name":"Yuying Wang","orcid":"https://orcid.org/0009-0007-9924-4409","observed_orcids":["https://orcid.org/0009-0007-9924-4409"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuying Wang","raw_affiliation_strings":["Behavioral Neuroscience Laboratory, Graduate School of Veterinary Medicine, Nippon Veterinary and Life Science University, 180-8602 Musashino, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Laboratory, Graduate School of Veterinary Medicine, Nippon Veterinary and Life Science University, 180-8602 Musashino, Tokyo, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034692201","display_name":"Chiaki Murayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143848","display_name":"Kracie (Japan)","ror":"https://ror.org/03z0jrc25","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210143848"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiaki Murayama","raw_affiliation_strings":["Kampo Research Laboratories, Kracie Pharma, Ltd., 3-1 Kanebo-machi, 933-0856 Takaoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo Research Laboratories, Kracie Pharma, Ltd., 3-1 Kanebo-machi, 933-0856 Takaoka, Japan","institution_ids":["https://openalex.org/I4210143848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010502909","display_name":"Seiwa Michihara","orcid":"https://orcid.org/0000-0002-6774-478X","observed_orcids":["https://orcid.org/0000-0002-6774-478X"]},"institutions":[{"id":"https://openalex.org/I4210143848","display_name":"Kracie (Japan)","ror":"https://ror.org/03z0jrc25","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210143848"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiwa Michihara","raw_affiliation_strings":["Kampo Research Laboratories, Kracie Pharma, Ltd., 3-1 Kanebo-machi, 933-0856 Takaoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo Research Laboratories, Kracie Pharma, Ltd., 3-1 Kanebo-machi, 933-0856 Takaoka, Japan","institution_ids":["https://openalex.org/I4210143848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087154845","display_name":"T\u00f4ru Sait\u00f4","orcid":"https://orcid.org/0000-0002-8388-4555","observed_orcids":["https://orcid.org/0000-0002-8388-4555"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru R. Saito","raw_affiliation_strings":["Behavioral Neuroscience Laboratory, Graduate School of Veterinary Medicine, Nippon Veterinary and Life Science University, 180-8602 Musashino, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Laboratory, Graduate School of Veterinary Medicine, Nippon Veterinary and Life Science University, 180-8602 Musashino, Tokyo, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089571563","display_name":"Hisayoshi Norimoto","orcid":"https://orcid.org/0000-0003-1036-9736","observed_orcids":["https://orcid.org/0000-0003-1036-9736"]},"institutions":[{"id":"https://openalex.org/I4210143848","display_name":"Kracie (Japan)","ror":"https://ror.org/03z0jrc25","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210143848"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hisayoshi Norimoto","raw_affiliation_strings":["Kampo Research Laboratories, Kracie Pharma, Ltd., 3-1 Kanebo-machi, 933-0856 Takaoka, Japan","+81-766-28-7953"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo Research Laboratories, Kracie Pharma, Ltd., 3-1 Kanebo-machi, 933-0856 Takaoka, Japan","institution_ids":["https://openalex.org/I4210143848"]},{"raw_affiliation_string":"+81-766-28-7953","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089571563"],"corresponding_institution_ids":["https://openalex.org/I4210143848"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.27,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5507157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"1","first_page":"33","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hachimijiogan","display_name":"Hachimijiogan","score":0.996999979019165},{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epididymal-spermatozoa","display_name":"epididymal sperm","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sperm-count","display_name":"sperm count","score":0.9010000228881836},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.7329999804496765},{"id":"https://openalex.org/keywords/oligospermia","display_name":"oligozoospermia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/seminal-vesicle","display_name":"seminal vesicle","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.781000018119812},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.8759999871253967},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/androgenic-activity","display_name":"androgenic activity","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2779626144","wikidata":"https://www.wikidata.org/wiki/Q403356","display_name":"Kampo","level":3,"score":0.7937664985656738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6718814969062805},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6289563775062561},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5884607434272766},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.5764630436897278},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5190528035163879},{"id":"https://openalex.org/C2777632594","wikidata":"https://www.wikidata.org/wiki/Q27116486","display_name":"Sperm motility","level":3,"score":0.5087295174598694},{"id":"https://openalex.org/C2781171107","wikidata":"https://www.wikidata.org/wiki/Q217259","display_name":"Seminal vesicle","level":4,"score":0.4990110397338867},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46940433979034424},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.4689856171607971},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.4640777111053467},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4638298749923706},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.43032222986221313},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.41304150223731995},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.3759843409061432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1444135308265686},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07664549350738525},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06609466671943665},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12522-014-0191-3","doi":"https://doi.org/10.1007/s12522-014-0191-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12522-014-0191-3","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-014-0191-3","source":{"id":"https://openalex.org/S86486980","display_name":"Reproductive Medicine and Biology","issn_l":"1445-5781","issn":["1445-5781","1447-0578"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Medicine and Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4646434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5715816","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29259400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29259400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive medicine and biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5715816","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5715816/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reprod Med Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12522-014-0191-3","doi":"https://doi.org/10.1007/s12522-014-0191-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12522-014-0191-3","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1007/s12522-014-0191-3","source":{"id":"https://openalex.org/S86486980","display_name":"Reproductive Medicine and Biology","issn_l":"1445-5781","issn":["1445-5781","1447-0578"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Medicine and Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091823971.pdf","grobid_xml":"https://content.openalex.org/works/W2091823971.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1503659850","https://openalex.org/W2000958343","https://openalex.org/W2005767486","https://openalex.org/W2054227830","https://openalex.org/W2060414102","https://openalex.org/W2069228493","https://openalex.org/W2110544661","https://openalex.org/W2156457451","https://openalex.org/W2161344855","https://openalex.org/W2328940319","https://openalex.org/W2394648907","https://openalex.org/W2397223499","https://openalex.org/W2399850320","https://openalex.org/W2400043087","https://openalex.org/W2410929153","https://openalex.org/W2422178775","https://openalex.org/W4210663054"],"related_works":["https://openalex.org/W2086539248","https://openalex.org/W2000990626","https://openalex.org/W98144642","https://openalex.org/W2372253824","https://openalex.org/W2765336520","https://openalex.org/W3117275759","https://openalex.org/W4206891048","https://openalex.org/W2015654515","https://openalex.org/W2057424984","https://openalex.org/W6988603934"],"abstract_inverted_index":{"Purpose:":[0],"Hachimijiogan":[1],"(HJG,":[2],"Rehmannia":[3],"Eight":[4],"Formula),":[5],"a":[6,168],"kidney-replenishing":[7],"Kampo":[8],"formula,":[9],"is":[10],"clinically":[11],"known":[12],"to":[13,30,51],"be":[14],"effective":[15],"in":[16,46,48],"the":[17,32,37,70,89,92,105,134,165],"treatment":[18],"of":[19,26,34,82,136,150,171],"male":[20],"infertility":[21],"with":[22,67,80],"oligozoospermia.":[23],"The":[24],"purpose":[25],"this":[27],"study":[28],"was":[29],"evaluate":[31],"effect":[33,175],"HJG":[35,75,125,146,172],"on":[36,176],"epididymal":[38],"sperm":[39,102,127],"characteristics":[40],"and":[41,85,110,116,129,139,152],"related":[42],"serum":[43,148],"hormone":[44,154,158],"changes":[45],"rats":[47],"an":[49,174],"attempt":[50],"determine":[52],"its":[53],"mechanism.":[54],"Methods:":[55],"=":[56],"6":[57],"for":[58,77,100],"each":[59],"group).":[60],"Apart":[61],"from":[62],"one":[63],"control":[64],"group":[65],"treated":[66],"distilled":[68],"water,":[69],"other":[71],"groups":[72],"were":[73,95,113],"administered":[74],"consecutively":[76],"9-11":[78],"days":[79],"doses":[81],"250,":[83],"500":[84],"1,000":[86],"mg/kg.":[87],"After":[88],"last":[90],"administration":[91],"caude":[93],"epididymides":[94],"quickly":[96],"removed":[97,114],"under":[98],"anesthesia":[99],"assessing":[101],"characteristics.":[103],"Additionally,":[104],"testes,":[106],"seminal":[107,137],"vesicles,":[108],"prostate":[109],"adrenal":[111,140,183],"glands":[112,141],"surgically":[115],"their":[117],"wet":[118],"weights":[119,135],"measured.":[120],"Results:":[121],"Results":[122],"showed":[123],"that":[124,167],"increased":[126],"numbers":[128],"motility":[130],"as":[131,133],"well":[132],"vesicles":[138],"at":[142],"lower":[143,169],"doses.":[144],"Moreover,":[145],"decreased":[147],"levels":[149],"testosterone":[151],"luteinizing":[153],"while":[155],"increasing":[156],"follicle-stimulating":[157],"levels.":[159],"Conclusions:":[160],"Our":[161],"findings":[162],"may":[163],"support":[164],"conclusion":[166],"dosage":[170],"has":[173],"improving":[177],"local":[178,187],"spermatogenous":[179],"environments":[180],"by":[181],"activating":[182],"functions":[184],"and/or":[185],"promoting":[186],"androgen":[188],"activity.":[189]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}