{"id":"https://openalex.org/W2091782967","doi":"https://doi.org/10.1093/jnci/dji240","title":"Cancer Incidence and Mortality in Men with Klinefelter Syndrome: A Cohort Study","display_name":"Cancer Incidence and Mortality in Men with Klinefelter Syndrome: A Cohort Study","publication_year":2005,"publication_date":"2005-08-16","ids":{"openalex":"https://openalex.org/W2091782967","doi":"https://doi.org/10.1093/jnci/dji240","mag":"2091782967","pmid":"https://pubmed.ncbi.nlm.nih.gov/16106025"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/dji240","doi":"https://doi.org/10.1093/jnci/dji240","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/dji240","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34619247","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028614473","display_name":"Anthony J. Swerdlow","orcid":"https://orcid.org/0000-0001-5550-4159","observed_orcids":["https://orcid.org/0000-0001-5550-4159"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4210129558","display_name":"Wessex Regional Genetics Laboratory","ror":"https://ror.org/02t83f864","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210129558","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Anthony J. Swerdlow","raw_affiliation_strings":["Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom. anthony.swerdlow@icr.ac.uk","Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom. anthony.swerdlow@icr.ac.uk","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","institution_ids":["https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I2799594651","https://openalex.org/I4210129558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005110817","display_name":"Minouk J. Schoemaker","orcid":"https://orcid.org/0000-0001-8403-2234","observed_orcids":["https://orcid.org/0000-0001-8403-2234"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4210129558","display_name":"Wessex Regional Genetics Laboratory","ror":"https://ror.org/02t83f864","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210129558","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Minouk J. Schoemaker","raw_affiliation_strings":["Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2799594651","https://openalex.org/I4210129558","https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","institution_ids":["https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I2799594651","https://openalex.org/I4210129558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111591872","display_name":"Craig D. Higgins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4210129558","display_name":"Wessex Regional Genetics Laboratory","ror":"https://ror.org/02t83f864","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210129558","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Craig D. Higgins","raw_affiliation_strings":["Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2799594651","https://openalex.org/I4210129558","https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","institution_ids":["https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I2799594651","https://openalex.org/I4210129558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109181222","display_name":"Alan F. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4210129558","display_name":"Wessex Regional Genetics Laboratory","ror":"https://ror.org/02t83f864","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210129558","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan F. Wright","raw_affiliation_strings":["Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2799594651","https://openalex.org/I4210129558","https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","institution_ids":["https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I2799594651","https://openalex.org/I4210129558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110153121","display_name":"Patricia A. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4210129558","display_name":"Wessex Regional Genetics Laboratory","ror":"https://ror.org/02t83f864","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210129558","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patricia A. Jacobs","raw_affiliation_strings":["Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH); Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW); Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2799594651","https://openalex.org/I4210129558","https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Affiliations of authors: Section of Epidemiology, Institute of Cancer Research, Sutton, United Kingdom (AJS, MJS, CDH)","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Cell and Molecular Genetics Section, MRC Human Genetics Unit, Edinburgh, United Kingdom (AFW)","institution_ids":["https://openalex.org/I4387154614"]},{"raw_affiliation_string":"Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom (PAJ)","institution_ids":["https://openalex.org/I2799594651","https://openalex.org/I4210129558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028614473"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2799594651","https://openalex.org/I4210129558","https://openalex.org/I4387154614"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":5.1901,"has_fulltext":false,"cited_by_count":314,"citation_normalized_percentile":{"value":0.96761717,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"97","issue":"16","first_page":"1204","last_page":"1210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klinefelter-syndrome","display_name":"Klinefelter syndrome","score":1.0},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cancer-mortality","display_name":"cancer mortality","score":1.0},{"id":"https://openalex.org/keywords/male-breast-cancer","display_name":"male breast cancer","score":0.7760000228881836},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/standardized-mortality-ratio","display_name":"standardized mortality ratio","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C102803821","wikidata":"https://www.wikidata.org/wiki/Q7598403","display_name":"Standardized mortality ratio","level":3,"score":0.7841958999633789},{"id":"https://openalex.org/C2776314099","wikidata":"https://www.wikidata.org/wiki/Q207133","display_name":"Klinefelter syndrome","level":2,"score":0.7765858769416809},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7516472339630127},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5499871373176575},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5467499494552612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5448647737503052},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5364129543304443},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5186066627502441},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5109290480613708},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.4816940724849701},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.46217554807662964},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4300094246864319},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.41800469160079956},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4160842299461365},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018567","descriptor_name":"Breast Neoplasms, Male","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/jnci/dji240","doi":"https://doi.org/10.1093/jnci/dji240","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/dji240","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:16106025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16106025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.598.8390","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.598.8390","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnci.oxfordjournals.org/content/97/16/1204.full.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.soton.ac.uk:24972","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/24972/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"doi:10.25405/ncl.34619247","doi":"https://doi.org/10.25405/ncl.34619247","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34619247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34619247.v1","doi":"https://doi.org/10.25405/ncl.34619247.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34619247.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34619247","doi":"https://doi.org/10.25405/ncl.34619247","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34619247","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1523010115","https://openalex.org/W1560091938","https://openalex.org/W1807550697","https://openalex.org/W1847808793","https://openalex.org/W1852554427","https://openalex.org/W1963558638","https://openalex.org/W1968390142","https://openalex.org/W1976944766","https://openalex.org/W1979300931","https://openalex.org/W1980610976","https://openalex.org/W1985398262","https://openalex.org/W1990930744","https://openalex.org/W2013339735","https://openalex.org/W2016185879","https://openalex.org/W2028510236","https://openalex.org/W2045060483","https://openalex.org/W2057251160","https://openalex.org/W2058476206","https://openalex.org/W2072679514","https://openalex.org/W2078426458","https://openalex.org/W2097820552","https://openalex.org/W2126606606","https://openalex.org/W2150688618","https://openalex.org/W2159457599","https://openalex.org/W2166769215","https://openalex.org/W2166859261","https://openalex.org/W2285652407","https://openalex.org/W2312235783","https://openalex.org/W2433649640","https://openalex.org/W2494440310","https://openalex.org/W2724744060","https://openalex.org/W2921357851","https://openalex.org/W3023527264","https://openalex.org/W3041047318","https://openalex.org/W3085323863","https://openalex.org/W4243669654","https://openalex.org/W4251756331","https://openalex.org/W4285719527","https://openalex.org/W4302773063"],"related_works":["https://openalex.org/W7095485972","https://openalex.org/W4405221388","https://openalex.org/W7096286861","https://openalex.org/W2028510236","https://openalex.org/W2027103571","https://openalex.org/W2078371695","https://openalex.org/W2044300551","https://openalex.org/W1523010115","https://openalex.org/W2126606606","https://openalex.org/W134328735"],"abstract_inverted_index":{"BACKGROUND:":[0],"Men":[1],"with":[2,24,64,80,113,118,186,204,244],"Klinefelter":[3,25,65,119,245],"syndrome":[4,26,66,120,246],"have":[5,13,18,27,37],"one":[6],"or":[7],"more":[8],"extra":[9],"X":[10],"chromosomes":[11],"and":[12,73,78,147,159,198,236,240],"endocrine":[14],"abnormalities.":[15],"Case":[16],"reports":[17],"led":[19],"to":[20,47,110,134,145,157,172,196,215],"suggestions":[21],"that":[22,81,242],"men":[23,58,83,117,185,203,235,243],"elevated":[28,251],"risks":[29,252],"of":[30,56,82],"several":[31],"cancers,":[32],"but":[33],"published":[34],"cohort":[35,45,55],"studies":[36],"been":[38,61],"relatively":[39],"small.":[40],"We":[41,52],"conducted":[42],"a":[43,54,205,228],"nationwide":[44],"study":[46],"examine":[48],"these":[49,222],"risks.":[50],"METHODS:":[51],"followed":[53],"3518":[57],"who":[59],"had":[60,121],"cytogenetically":[62],"diagnosed":[63],"in":[67,84,234],"Britain":[68],"from":[69,124,162],"1959":[70],"through":[71],"2002":[72],"compared":[74],"their":[75],"cancer":[76,126,137,164,183,218,233,239],"incidence":[77,219],"mortality":[79,96,123,161,176],"the":[85,114],"national":[86],"population.":[87],"All":[88],"statistical":[89],"tests":[90],"were":[91,178],"two-sided.":[92],"RESULTS:":[93],"The":[94,174,217],"standardized":[95,175],"ratio":[97],"(SMR)":[98],"for":[99,181,199,231,237,253],"all":[100],"cancers":[101],"was":[102],"1.2":[103],"(95%":[104],"confidence":[105],"interval":[106],"[CI]":[107],"=":[108,128,132,139,143,151,155,166,170,190,194,209,213],"1.0":[109,133],"1.4).":[111],"Compared":[112],"general":[115],"population,":[116],"higher":[122],"lung":[125,260],"(SMR":[127,138,150,165,189,208],"1.5,":[129],"95%":[130,141,153,168,192,211],"CI":[131,142,154,169,193,212],"2.0),":[135],"breast":[136,182,232,256],"57.8,":[140],"18.8":[144],"135.0),":[146],"non-Hodgkin":[148,200,254],"lymphoma":[149,201],"3.5,":[152],"1.6":[156],"6.6)":[158],"lower":[160],"prostate":[163,238],"0,":[167],"0":[171],"0.7).":[173],"ratios":[177],"particularly":[179],"high":[180],"among":[184,202],"47,XXY":[187],"mosaicism":[188],"222.8,":[191],"45.9":[195],"651.0)":[197],"48,XXYY":[206],"constitution":[207],"36.7,":[210],"4.4":[214],"132.5).":[216],"data":[220],"corroborated":[221],"associations.":[223],"CONCLUSIONS:":[224],"These":[225],"results":[226],"support":[227],"hormonal":[229],"etiology":[230],"suggest":[241],"may":[247],"be":[248],"at":[249],"substantially":[250],"lymphoma,":[255],"cancer,":[257],"and,":[258],"perhaps,":[259],"cancer.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}