{"id":"https://openalex.org/W2091743718","doi":"https://doi.org/10.1007/s40256-012-0002-3","title":"Icosapent Ethyl, a Pure Ethyl Ester of Eicosapentaenoic Acid: Effects on Circulating Markers of Inflammation from the MARINE and ANCHOR Studies","display_name":"Icosapent Ethyl, a Pure Ethyl Ester of Eicosapentaenoic Acid: Effects on Circulating Markers of Inflammation from the MARINE and ANCHOR Studies","publication_year":2013,"publication_date":"2013-01-16","ids":{"openalex":"https://openalex.org/W2091743718","doi":"https://doi.org/10.1007/s40256-012-0002-3","mag":"2091743718","pmid":"https://pubmed.ncbi.nlm.nih.gov/23325450","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3572383"},"language":"en","primary_location":{"id":"doi:10.1007/s40256-012-0002-3","doi":"https://doi.org/10.1007/s40256-012-0002-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40256-012-0002-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40256-012-0002-3.pdf","source":{"id":"https://openalex.org/S151621711","display_name":"American Journal of Cardiovascular Drugs","issn_l":"1175-3277","issn":["1175-3277","1179-187X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Cardiovascular Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s40256-012-0002-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053191013","display_name":"Harold Edward Bays","orcid":"https://orcid.org/0000-0001-9912-1408","observed_orcids":["https://orcid.org/0000-0001-9912-1408"]},"institutions":[{"id":"https://openalex.org/I4210132010","display_name":"Louisville Metabolic and Atherosclerosis Research Center","ror":"https://ror.org/030y83r80","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210132010"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harold E. Bays","raw_affiliation_strings":["Louisville Metabolic and Atherosclerosis Research Center, 3288 Illinois Avenue, Louisville, KY 40213, USA. HBaysMD@aol.com","Louisville Metabolic and Atherosclerosis Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisville Metabolic and Atherosclerosis Research Center, 3288 Illinois Avenue, Louisville, KY 40213, USA. HBaysMD@aol.com","institution_ids":["https://openalex.org/I4210132010"]},{"raw_affiliation_string":"Louisville Metabolic and Atherosclerosis Research Center","institution_ids":["https://openalex.org/I4210132010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052604218","display_name":"Christie Mitchell Ballantyne","orcid":"https://orcid.org/0000-0002-6432-1730","observed_orcids":["https://orcid.org/0000-0002-6432-1730"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christie M. Ballantyne","raw_affiliation_strings":["Baylor College of Medicine and the Methodist DeBakey Heart and Vascular Center, Houston, TX, USA","Baylor College of Medicine and the Methodist DeBakey Heart and Vascular Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine and the Methodist DeBakey Heart and Vascular Center, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine and the Methodist DeBakey Heart and Vascular Center","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023941702","display_name":"Rene A. Braeckman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130338","display_name":"Amarin (United States)","ror":"https://ror.org/0353d6x38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113585","https://openalex.org/I4210130338"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rene A. Braeckman","raw_affiliation_strings":["Amarin Pharma, Inc., Bedminster, NJ, USA","Amarin Pharma, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amarin Pharma, Inc., Bedminster, NJ, USA","institution_ids":["https://openalex.org/I4210130338"]},{"raw_affiliation_string":"Amarin Pharma, Inc","institution_ids":["https://openalex.org/I4210130338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072198197","display_name":"William G. Stirtan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130338","display_name":"Amarin (United States)","ror":"https://ror.org/0353d6x38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113585","https://openalex.org/I4210130338"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William G. Stirtan","raw_affiliation_strings":["Amarin Pharma, Inc., Groton, CT, USA","Amarin Pharma, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amarin Pharma, Inc., Groton, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Amarin Pharma, Inc","institution_ids":["https://openalex.org/I4210130338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111956234","display_name":"Paresh N. Soni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130338","display_name":"Amarin (United States)","ror":"https://ror.org/0353d6x38","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113585","https://openalex.org/I4210130338"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paresh N. Soni","raw_affiliation_strings":["Amarin Pharma, Inc., Groton, CT, USA","Amarin Pharma, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amarin Pharma, Inc., Groton, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Amarin Pharma, Inc","institution_ids":["https://openalex.org/I4210130338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053191013"],"corresponding_institution_ids":["https://openalex.org/I4210132010"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":8.2176,"has_fulltext":true,"cited_by_count":141,"citation_normalized_percentile":{"value":0.98115861,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"37","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icosapent-ethyl","display_name":"icosapent ethyl","score":0.8709999918937683},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid-ethyl-ester","display_name":"eicosapentaenoic acid ethyl ester","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/atherosclerotic-inflammation","display_name":"atherosclerotic inflammation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7749999761581421},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.925000011920929},{"id":"https://openalex.org/keywords/lipoprotein-associated-phospholipase-a2","display_name":"lipoprotein-associated phospholipase A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9399999976158142},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.7972462177276611},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6445889472961426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6259598135948181},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6195782423019409},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.5799176692962646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5779848694801331},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5273410081863403},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4727117717266083},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4671133756637573},{"id":"https://openalex.org/C2994242795","wikidata":"https://www.wikidata.org/wiki/Q101487","display_name":"Ethyl ester","level":2,"score":0.4309418797492981},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4236019253730774},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.4188506007194519},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3511439561843872},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34930381178855896},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2711646556854248},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24609607458114624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17489361763000488},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.15980809926986694},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1234382688999176},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015118","descriptor_name":"Eicosapentaenoic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015118","descriptor_name":"Eicosapentaenoic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s40256-012-0002-3","doi":"https://doi.org/10.1007/s40256-012-0002-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40256-012-0002-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40256-012-0002-3.pdf","source":{"id":"https://openalex.org/S151621711","display_name":"American Journal of Cardiovascular Drugs","issn_l":"1175-3277","issn":["1175-3277","1179-187X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Cardiovascular Drugs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2576048","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3572383","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3572383","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3572383","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cardiovasc Drugs","raw_type":"Text"},{"id":"pmid:23325450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23325450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cardiovascular drugs : drugs, devices, and other interventions","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.813.6854","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.813.6854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/08/ba/40256_2012_Article_2.PMC3572383.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/s40256-012-0002-3","doi":"https://doi.org/10.1007/s40256-012-0002-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40256-012-0002-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40256-012-0002-3.pdf","source":{"id":"https://openalex.org/S151621711","display_name":"American Journal of Cardiovascular Drugs","issn_l":"1175-3277","issn":["1175-3277","1179-187X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Cardiovascular Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"},{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320309466","display_name":"Medpace","ror":"https://ror.org/05mgcmd27"},{"id":"https://openalex.org/F4320310096","display_name":"Alere","ror":"https://ror.org/01zt0tq34"},{"id":"https://openalex.org/F4320315027","display_name":"Amarin Corporation","ror":"https://ror.org/02fccce66"},{"id":"https://openalex.org/F4320316238","display_name":"Kowa Company","ror":"https://ror.org/009z2z347"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320323316","display_name":"Shionogi","ror":"https://ror.org/01v3bqg10"},{"id":"https://openalex.org/F4320331660","display_name":"Esperion Therapeutics","ror":"https://ror.org/019f2k932"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320333619","display_name":"Amarin Pharma","ror":"https://ror.org/0353d6x38"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091743718.pdf","grobid_xml":"https://content.openalex.org/works/W2091743718.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W52052328","https://openalex.org/W1508808956","https://openalex.org/W1650965741","https://openalex.org/W1933509585","https://openalex.org/W1972919038","https://openalex.org/W1979893667","https://openalex.org/W1982503330","https://openalex.org/W1987709455","https://openalex.org/W1990092121","https://openalex.org/W1995350891","https://openalex.org/W1998826672","https://openalex.org/W2001687790","https://openalex.org/W2007510171","https://openalex.org/W2018239666","https://openalex.org/W2018575939","https://openalex.org/W2028936188","https://openalex.org/W2045529471","https://openalex.org/W2049746695","https://openalex.org/W2053451795","https://openalex.org/W2058023006","https://openalex.org/W2062115516","https://openalex.org/W2063668393","https://openalex.org/W2066530607","https://openalex.org/W2090162029","https://openalex.org/W2093598997","https://openalex.org/W2108868980","https://openalex.org/W2109017956","https://openalex.org/W2123713555","https://openalex.org/W2137983259","https://openalex.org/W2142347023","https://openalex.org/W2143064104","https://openalex.org/W2145009492","https://openalex.org/W2147181044","https://openalex.org/W2159526885","https://openalex.org/W2160398757","https://openalex.org/W2167747180","https://openalex.org/W2289516061","https://openalex.org/W2316243284","https://openalex.org/W2569568519","https://openalex.org/W3022401702"],"related_works":["https://openalex.org/W7100030723","https://openalex.org/W2149937091","https://openalex.org/W2546771350","https://openalex.org/W2950227430","https://openalex.org/W3200159418","https://openalex.org/W2134172530","https://openalex.org/W2472970460","https://openalex.org/W4380200478","https://openalex.org/W2057293475","https://openalex.org/W2163381397"],"abstract_inverted_index":{"BACKGROUND:":[0],"Icosapent":[1],"ethyl":[2,12],"(IPE)":[3],"is":[4],"a":[5],"high-purity":[6],"prescription":[7],"form":[8],"of":[9,93,146,267],"eicosapentaenoic":[10],"acid":[11],"ester":[13],"approved":[14],"by":[15],"the":[16,91,134,224,246],"US":[17],"Food":[18],"and":[19,51,73,79,102,109,165,199,220,286],"Drug":[20],"Administration":[21],"as":[22,150],"an":[23],"adjunct":[24],"to":[25,27,42,123,172,243,274],"diet":[26],"reduce":[28],"triglyceride":[29],"(TG)":[30],"levels":[31,54,68,83,201,255,266],"in":[32,62,74,98,141,245,276],"adult":[33],"patients":[34,63,75,99,122],"with":[35,64,76],"severe":[36],"(\u2265500":[37],"mg/dL)":[38],"hypertriglyceridemia.":[39],"In":[40,223],"addition":[41],"TG-lowering":[43],"effects,":[44],"IPE":[45,94,124,174,227,249,279],"also":[46],"reduces":[47],"non-high-density":[48],"lipoprotein":[49,59,157],"cholesterol":[50,60],"apolipoprotein":[52],"B":[53],"without":[55],"significantly":[56,177,217,232,252,264,282],"increasing":[57],"low-density":[58,156],"(LDL-C)":[61],"very":[65],"high":[66,81],"TG":[67,82],"\u2265500":[69],"mg/dL":[70,85],"(MARINE":[71],"study)":[72],"well-controlled":[77],"LDL-C":[78],"residually":[80],"200-500":[84],"(ANCHOR":[86],"study).":[87],"This":[88,131],"analysis":[89,132],"examined":[90],"effect":[92],"on":[95],"inflammatory":[96,270],"markers":[97,142],"from":[100,139],"MARINE":[101,105,225],"ANCHOR.":[103],"METHODS:":[104],"(N":[106,111],"=":[107,112],"229)":[108],"ANCHOR":[110,247],"702)":[113],"were":[114],"Phase":[115],"III,":[116],"double-blind":[117],"studies":[118],"that":[119],"randomized":[120],"hypertriglyceridemic":[121,277],"4":[125,175,280],"g/day,":[126,128],"2":[127,228,250],"or":[129,238],"placebo.":[130],"assessed":[133,269],"median":[135],"placebo-adjusted":[136],"percentage":[137],"change":[138,218,233,265],"baseline":[140],"representing":[143],"various":[144],"stages":[145],"atherosclerotic":[147],"inflammation":[148],"such":[149],"intercellular":[151],"adhesion":[152],"molecule-1":[153],"(ICAM-1),":[154],"oxidized":[155],"(Ox-LDL),":[158],"lipoprotein-associated":[159],"phospholipase":[160],"A(2)":[161],"(Lp-PLA(2)),":[162],"interleukin-6":[163],"(IL-6),":[164],"high-sensitivity":[166],"C-reactive":[167],"protein":[168],"(hsCRP).":[169],"RESULTS:":[170],"Compared":[171,273],"placebo,":[173,275],"g/day":[176,229,251,281],"decreased":[178,253,283],"Ox-LDL":[179],"(13":[180],"%,":[181,188,194,203,209,257],"p":[182,189,195,204,210,258],"<":[183,190,196,205,211,259],"0.0001,":[184,197],"ANCHOR),":[185,198,213],"Lp-PLA(2)":[186,254],"(14":[187],"0.001,":[191,212],"MARINE;":[192,207],"19":[193],"hsCRP":[200,239,287],"(36":[202],"0.01,":[206],"22":[208],"but":[214,261],"did":[215,230,262],"not":[216,231,263],"ICAM-1":[219],"IL-6":[221],"levels.":[222,240,288],"study,":[226,248],"ICAM-1,":[234],"Ox-LDL,":[235,284],"Lp-PLA(2),":[236,285],"IL-6,":[237],"Also,":[241],"compared":[242],"placebo":[244],"(8":[256],"0.0001),":[260],"other":[268],"markers.":[271],"CONCLUSION:":[272],"patients,":[278]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
