{"id":"https://openalex.org/W2091708447","doi":"https://doi.org/10.1084/jem.20082845","title":"Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2)","display_name":"Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2)","publication_year":2009,"publication_date":"2009-10-19","ids":{"openalex":"https://openalex.org/W2091708447","doi":"https://doi.org/10.1084/jem.20082845","mag":"2091708447","pmid":"https://pubmed.ncbi.nlm.nih.gov/19841087","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2768859"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20082845","doi":"https://doi.org/10.1084/jem.20082845","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20082845","pdf_url":"https://rupress.org/jem/article-pdf/206/11/2397/1197826/jem_20082845.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/206/11/2397/1197826/jem_20082845.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011320255","display_name":"Per Fogelstrand","orcid":"https://orcid.org/0000-0003-1879-6441","observed_orcids":["https://orcid.org/0000-0003-1879-6441"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Per Fogelstrand","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084415045","display_name":"Chlo\u00e9 C. F\u00e9ral","orcid":"https://orcid.org/0000-0001-9756-2082","observed_orcids":["https://orcid.org/0000-0001-9756-2082"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Chlo\u00e9 C. F\u00e9ral","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Avenir Team, U634, Nice Sophia Antipolis University, 06107 Nice, Cedex 2, France 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Avenir Team, U634, Nice Sophia Antipolis University, 06107 Nice, Cedex 2, France 2","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033038929","display_name":"Ramin Zargham","orcid":"https://orcid.org/0009-0001-8943-7115","observed_orcids":["https://orcid.org/0009-0001-8943-7115","https://orcid.org/0000-0003-2292-7862"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramin Zargham","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032907445","display_name":"Mark H. Ginsberg","orcid":"https://orcid.org/0000-0002-5685-5417","observed_orcids":["https://orcid.org/0000-0002-5685-5417"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark H. Ginsberg","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92093 1","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032907445"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":2.27,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.87268178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"206","issue":"11","first_page":"2397","last_page":"2406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.538100004196167,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.538100004196167,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.19380000233650208,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slc3a2","display_name":"SLC3A2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.796999990940094},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.8450000286102295},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.8799999952316284},{"id":"https://openalex.org/keywords/amino-acid-transporters","display_name":"amino acid transporters","score":0.8870000243186951},{"id":"https://openalex.org/keywords/in-stent-restenosis","display_name":"in-stent restenosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vein-graft-stenosis","display_name":"vein graft stenosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/transplant-vasculopathy","display_name":"transplant vasculopathy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5540000200271606},{"id":"https://openalex.org/keywords/arterial-injury","display_name":"arterial injury","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.8708720207214355},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.7450275421142578},{"id":"https://openalex.org/C2779751240","wikidata":"https://www.wikidata.org/wiki/Q16909635","display_name":"Intimal hyperplasia","level":3,"score":0.6656939387321472},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6400070190429688},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5940532088279724},{"id":"https://openalex.org/C2778095995","wikidata":"https://www.wikidata.org/wiki/Q17147174","display_name":"Neointimal hyperplasia","level":4,"score":0.5690403580665588},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5496328473091125},{"id":"https://openalex.org/C2777339539","wikidata":"https://www.wikidata.org/wiki/Q6993039","display_name":"Neointima","level":4,"score":0.5431607365608215},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4800516366958618},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4782918095588684},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4548999071121216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4075438678264618},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3676356077194214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28208494186401367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22671020030975342},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21999365091323853},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.1774137318134308},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.141264408826828},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12331444025039673},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027282","descriptor_name":"Fusion Regulatory Protein 1, Heavy Chain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.20082845","doi":"https://doi.org/10.1084/jem.20082845","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20082845","pdf_url":"https://rupress.org/jem/article-pdf/206/11/2397/1197826/jem_20082845.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2768859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2768859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:19841087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19841087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9f8986dg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9f8986dg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of experimental medicine, vol 206, iss 11","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9f8986dg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9f8986dg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Medicine, vol 206, iss 11","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1084/jem.20082845","doi":"https://doi.org/10.1084/jem.20082845","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20082845","pdf_url":"https://rupress.org/jem/article-pdf/206/11/2397/1197826/jem_20082845.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1955225794","display_name":"Regulation of Integrin Alpha4 Betal","funder_award_id":"R01AR027214","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G282693604","display_name":"PLATELETS IN RHEUMATIC DISEASE","funder_award_id":"R37AR027214","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3263340342","display_name":null,"funder_award_id":"AR 27214","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7165442718","display_name":"Cell Adhesion Mechanisms in Vascular Disease & Thrombosis","funder_award_id":"P01HL078784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G882865996","display_name":"Thrombus Formation and Antithrombotic Intervention","funder_award_id":"P01HL031950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091708447.pdf","grobid_xml":"https://content.openalex.org/works/W2091708447.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1437280","https://openalex.org/W153662504","https://openalex.org/W1509578913","https://openalex.org/W1526085928","https://openalex.org/W1651672993","https://openalex.org/W1848549644","https://openalex.org/W1887906450","https://openalex.org/W1968171440","https://openalex.org/W1968460690","https://openalex.org/W1977427723","https://openalex.org/W1986476951","https://openalex.org/W1992322558","https://openalex.org/W2001793664","https://openalex.org/W2002256788","https://openalex.org/W2002753332","https://openalex.org/W2004298264","https://openalex.org/W2005809578","https://openalex.org/W2014691356","https://openalex.org/W2015729243","https://openalex.org/W2020898985","https://openalex.org/W2023953170","https://openalex.org/W2034118963","https://openalex.org/W2035105295","https://openalex.org/W2037165553","https://openalex.org/W2042162619","https://openalex.org/W2072619403","https://openalex.org/W2087454309","https://openalex.org/W2092282197","https://openalex.org/W2103532601","https://openalex.org/W2103894337","https://openalex.org/W2108105475","https://openalex.org/W2108486099","https://openalex.org/W2137287545","https://openalex.org/W2138668121","https://openalex.org/W2141709269","https://openalex.org/W2142157313","https://openalex.org/W2147960762","https://openalex.org/W2150750426","https://openalex.org/W2151970821","https://openalex.org/W2157050965","https://openalex.org/W2158030378","https://openalex.org/W2160500503","https://openalex.org/W2161191369","https://openalex.org/W2163011809","https://openalex.org/W2168257088","https://openalex.org/W2171239535","https://openalex.org/W2321645860","https://openalex.org/W6630634289","https://openalex.org/W6639500564"],"related_works":["https://openalex.org/W93458711","https://openalex.org/W7036533684","https://openalex.org/W2006817629","https://openalex.org/W2276515547","https://openalex.org/W3165364853","https://openalex.org/W2906384245","https://openalex.org/W1971354041","https://openalex.org/W7162437775","https://openalex.org/W4410007731","https://openalex.org/W1993090905"],"abstract_inverted_index":{"Activation":[0],"of":[1,16,81,98,117,142,149,158],"vascular":[2],"smooth":[3],"muscle":[4],"cells":[5],"(VSMCs)":[6],"to":[7,75,163],"migrate":[8],"and":[9,37,52,55,70,113,121,154,180],"proliferate":[10],"is":[11,24,47,183],"essential":[12],"for":[13,64,95,139],"the":[14,76,96,140,147],"formation":[15],"intimal":[17,106],"hyperplasia.":[18],"Hence,":[19],"selectively":[20,161],"targeting":[21],"activated":[22,57,164,173],"VSMCs":[23,61,165,174],"a":[25,184],"potential":[26,185],"strategy":[27],"against":[28],"vaso-occlusive":[29,189],"disorders":[30],"such":[31],"as":[32],"in-stent":[33],"restenosis,":[34],"vein-graft":[35],"stenosis,":[36],"transplant":[38],"vasculopathy.":[39],"We":[40],"show":[41],"that":[42,56,90,132,172],"CD98":[43],"heavy":[44],"chain":[45],"(CD98hc)":[46],"markedly":[48],"up-regulated":[49],"in":[50,114,124,151,188],"neointimal":[51],"cultured":[53],"VSMCs,":[54,170],"but":[58],"not":[59,84,93],"quiescent":[60,100,169],"require":[62],"CD98hc":[63,66,82,91,103,118,129,133,150,159,182],"survival.":[65,155],"mediates":[67],"integrin":[68],"signaling":[69],"localizes":[71],"amino":[72],"acid":[73],"transporters":[74],"plasma":[77],"membrane.":[78],"SMC-specific":[79],"deletion":[80,104],"did":[83],"affect":[85],"normal":[86],"vessel":[87],"morphology,":[88],"indicating":[89],"was":[92,137,160],"required":[94],"maintenance":[97],"resident":[99,168],"VSMCs;":[101],"however,":[102],"reduced":[105],"hyperplasia":[107],"after":[108],"arterial":[109],"injury.":[110],"Ex":[111],"vivo":[112],"vitro,":[115],"loss":[116,157],"suppressed":[119],"proliferation":[120,153],"induced":[122],"apoptosis":[123],"VSMCs.":[125,143],"Furthermore,":[126,156],"reconstitution":[127],"with":[128,135],"mutants":[130],"showed":[131],"interaction":[134],"integrins":[136],"necessary":[138],"survival":[141],"These":[144],"studies":[145],"establish":[146],"importance":[148],"VSMC":[152],"deleterious":[162],"while":[166],"sparing":[167],"suggesting":[171],"are":[175],"physiologically":[176],"dependent":[177],"on":[178],"CD98hc,":[179],"hence,":[181],"therapeutic":[186],"target":[187],"disorders.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}