{"id":"https://openalex.org/W20916664","doi":null,"title":"Genetic tests for predicting the toxicity and efficacy of anticancer chemotherapy.","display_name":"Genetic tests for predicting the toxicity and efficacy of anticancer chemotherapy.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W20916664","mag":"20916664","pmid":"https://pubmed.ncbi.nlm.nih.gov/17447847"},"language":"en","primary_location":{"id":"pmid:17447847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17447847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049881105","display_name":"Be\u00e1ta Mladosievi\u010dov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"B Mladosievicova","raw_affiliation_strings":["Institute of Pathological Physiology, Comenius University, Bratislava, Slovakia. beata.mladosievicova@fmed.uniba.sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathological Physiology, Comenius University, Bratislava, Slovakia. beata.mladosievicova@fmed.uniba.sk","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007816608","display_name":"A Carter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007680997","display_name":"Viera Kristov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Kristova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2023,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.50140887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"54","issue":"3","first_page":"181","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.921999990940094},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8429999947547913},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7139999866485596},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.7950000166893005},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9760000109672546},{"id":"https://openalex.org/keywords/platinum-analogues","display_name":"platinum analogues","score":0.8500000238418579},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.7929999828338623},{"id":"https://openalex.org/keywords/6-thioguanine","display_name":"6-thioguanine","score":0.8399999737739563},{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.915440559387207},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.7702150344848633},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.7481110095977783},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6023046374320984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5898035764694214},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5747409462928772},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4972873032093048},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4972422420978546},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44786518812179565},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4087660014629364},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3496090769767761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30554211139678955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18106743693351746},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.15726041793823242},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11498209834098816},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08398786187171936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05966383218765259}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17447847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17447847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"},{"id":"mag:20916664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17447847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W42797104","https://openalex.org/W133121928","https://openalex.org/W235129562","https://openalex.org/W1503862265","https://openalex.org/W1507760891","https://openalex.org/W1596051841","https://openalex.org/W1626344016","https://openalex.org/W1850914599","https://openalex.org/W1863587549","https://openalex.org/W1964551051","https://openalex.org/W1965659514","https://openalex.org/W1966580149","https://openalex.org/W1967236703","https://openalex.org/W1970106379","https://openalex.org/W1970171095","https://openalex.org/W1971336136","https://openalex.org/W1974895424","https://openalex.org/W1978894185","https://openalex.org/W1982486186","https://openalex.org/W1988005402","https://openalex.org/W1988658163","https://openalex.org/W1993258963","https://openalex.org/W1995961103","https://openalex.org/W2001337137","https://openalex.org/W2010037109","https://openalex.org/W2011607101","https://openalex.org/W2024913341","https://openalex.org/W2032534059","https://openalex.org/W2042701803","https://openalex.org/W2065214599","https://openalex.org/W2071035298","https://openalex.org/W2075204434","https://openalex.org/W2076472107","https://openalex.org/W2076959644","https://openalex.org/W2078364405","https://openalex.org/W2078671723","https://openalex.org/W2081295469","https://openalex.org/W2084271415","https://openalex.org/W2090910729","https://openalex.org/W2106184659","https://openalex.org/W2107262592","https://openalex.org/W2108208897","https://openalex.org/W2109133025","https://openalex.org/W2110922057","https://openalex.org/W2111055432","https://openalex.org/W2113911127","https://openalex.org/W2116846790","https://openalex.org/W2119088090","https://openalex.org/W2121398847","https://openalex.org/W2122265695","https://openalex.org/W2122551548","https://openalex.org/W2125672083","https://openalex.org/W2127449669","https://openalex.org/W2127815633","https://openalex.org/W2132164717","https://openalex.org/W2138334001","https://openalex.org/W2138849304","https://openalex.org/W2139458933","https://openalex.org/W2146922312","https://openalex.org/W2147162951","https://openalex.org/W2155033804","https://openalex.org/W2159370558","https://openalex.org/W2248676770","https://openalex.org/W2273438898","https://openalex.org/W2286312784","https://openalex.org/W2322536880","https://openalex.org/W2335253526","https://openalex.org/W2401765975","https://openalex.org/W2407410471","https://openalex.org/W2412417703","https://openalex.org/W2412753674","https://openalex.org/W2964661187"],"related_works":["https://openalex.org/W2804668368","https://openalex.org/W2520242613","https://openalex.org/W2054558236","https://openalex.org/W3047300470","https://openalex.org/W2014722248","https://openalex.org/W1492885452","https://openalex.org/W2416104147","https://openalex.org/W4385780819","https://openalex.org/W4380290887","https://openalex.org/W155403924"],"abstract_inverted_index":{"The":[0,75],"standard":[1],"anticancer":[2,43,95],"therapy":[3],"based":[4],"\"on":[5],"one":[6],"size":[7],"fits":[8],"all\"":[9],"modality":[10],"has":[11],"been":[12,38],"determined":[13,98],"to":[14,18,58],"be":[15,19],"ineffective":[16],"or":[17],"the":[20,100],"cause":[21],"of":[22,42,66,77,88,93,102,124],"adverse":[23],"drug":[24,89],"reactions":[25],"in":[26,54,110,127],"many":[27],"oncologic":[28],"patients.":[29],"Most":[30],"pharmacogenetic":[31,79],"and":[32,73,122],"pharmacogenomic":[33],"studies":[34,80],"so":[35],"far":[36],"have":[37],"focused":[39],"on":[40,82],"toxicity":[41,123],"drugs":[44,96,125],"such":[45,68],"as":[46,69,86],"6-mercaptopurine,":[47],"thioguanine,":[48],"irinotecan,":[49],"methotrexate,":[50],"5-fluorouracil":[51],"(5-FU).":[52],"Variation":[53],"genes":[55],"are":[56,97,108],"known":[57],"influence":[59],"not":[60],"only":[61],"toxicity,":[62],"but":[63],"also":[64],"efficacy":[65,121],"chemotherapeutics":[67],"platinum":[70],"analogues,":[71],"5-FU":[72],"irinotecan.":[74],"majority":[76],"current":[78],"focus":[81],"single":[83],"enzyme":[84],"deficiencies":[85],"predictors":[87],"effects;":[90],"however":[91],"effects":[92,107],"most":[94],"by":[99],"interplay":[101],"several":[103],"gene":[104],"products.":[105],"These":[106],"polygenic":[109],"nature.":[111],"This":[112],"review":[113],"briefly":[114],"describes":[115],"genetic":[116],"variations":[117],"that":[118],"may":[119],"impact":[120],"used":[126],"cancer":[128],"chemotherapy.":[129]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}