{"id":"https://openalex.org/W2091663233","doi":"https://doi.org/10.1042/bj20050533","title":"Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression","display_name":"Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression","publication_year":2005,"publication_date":"2005-10-25","ids":{"openalex":"https://openalex.org/W2091663233","doi":"https://doi.org/10.1042/bj20050533","mag":"2091663233","pmid":"https://pubmed.ncbi.nlm.nih.gov/16014005"},"language":"en","primary_location":{"id":"doi:10.1042/bj20050533","doi":"https://doi.org/10.1042/bj20050533","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20050533","pdf_url":"https://portlandpress.com/biochemj/article-pdf/391/3/503/640242/bj3910503.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/391/3/503/640242/bj3910503.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074525368","display_name":"Natalia V. Oleinik","orcid":"https://orcid.org/0000-0002-6658-9140","observed_orcids":["https://orcid.org/0000-0002-6658-9140"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia\u00a0V. Oleinik","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083752966","display_name":"Natalia I. Krupenko","orcid":"https://orcid.org/0000-0003-2977-1557","observed_orcids":["https://orcid.org/0000-0003-2977-1557"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia\u00a0I. Krupenko","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086799202","display_name":"David G. Priest","orcid":"https://orcid.org/0000-0003-0095-6718","observed_orcids":["https://orcid.org/0000-0003-0095-6718"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David\u00a0G. Priest","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067376130","display_name":"Sergey A. Krupenko","orcid":"https://orcid.org/0000-0002-6926-2776","observed_orcids":["https://orcid.org/0000-0002-6926-2776"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey\u00a0A. Krupenko","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":null,"apc_paid":null,"fwci":1.271,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.79457811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"391","issue":"3","first_page":"503","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/10-formyltetrahydrofolate-dehydrogenase","display_name":"10-formyltetrahydrofolate dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/p53-dependent-apoptosis","display_name":"p53-dependent apoptosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.9390000104904175},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.8399999737739563},{"id":"https://openalex.org/keywords/lung-cancer-cells","display_name":"lung cancer cells","score":0.621999979019165},{"id":"https://openalex.org/keywords/colorectal-cancer-cells","display_name":"colorectal cancer cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/p53-knockdown","display_name":"p53 knockdown","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dominant-negative-p53","display_name":"dominant-negative p53","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6947277784347534},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.6872941255569458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6310195922851562},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6295025944709778},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5859660506248474},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5517938137054443},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.523343026638031},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5203958749771118},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4791933298110962},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.46473219990730286},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4577348232269287},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.45424920320510864},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.446432501077652},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42958712577819824},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37409842014312744},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3666858673095703},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.30219176411628723},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2688547968864441},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2395678460597992},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1939835548400879},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16313466429710388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1254991888999939},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08041602373123169},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07714340090751648}],"mesh":[{"descriptor_ui":"D000099295","descriptor_name":"Formyltetrahydrofolate Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj20050533","doi":"https://doi.org/10.1042/bj20050533","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20050533","pdf_url":"https://portlandpress.com/biochemj/article-pdf/391/3/503/640242/bj3910503.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:16014005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16014005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1276951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1276951","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bj20050533","doi":"https://doi.org/10.1042/bj20050533","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20050533","pdf_url":"https://portlandpress.com/biochemj/article-pdf/391/3/503/640242/bj3910503.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7099999785423279,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3539083011","display_name":null,"funder_award_id":"DK-54388","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G618421067","display_name":null,"funder_award_id":"R01 DK054388","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000065064","display_name":null,"funder_award_id":"DK54388","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332464","display_name":"Hollings Cancer Center, Medical University of South Carolina","ror":"https://ror.org/00w52vt71"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091663233.pdf","grobid_xml":"https://content.openalex.org/works/W2091663233.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W6853850","https://openalex.org/W48394690","https://openalex.org/W155393863","https://openalex.org/W1516866556","https://openalex.org/W1522177431","https://openalex.org/W1565881767","https://openalex.org/W1616121322","https://openalex.org/W1650797637","https://openalex.org/W1937607074","https://openalex.org/W1973569587","https://openalex.org/W1990789249","https://openalex.org/W1991544955","https://openalex.org/W1995449101","https://openalex.org/W1997607156","https://openalex.org/W2008257691","https://openalex.org/W2021229163","https://openalex.org/W2021491682","https://openalex.org/W2022162825","https://openalex.org/W2022762967","https://openalex.org/W2023917814","https://openalex.org/W2029030998","https://openalex.org/W2032603938","https://openalex.org/W2038291224","https://openalex.org/W2038783205","https://openalex.org/W2050419712","https://openalex.org/W2053462331","https://openalex.org/W2056530510","https://openalex.org/W2063669247","https://openalex.org/W2064790766","https://openalex.org/W2068691401","https://openalex.org/W2078091557","https://openalex.org/W2079706088","https://openalex.org/W2080125477","https://openalex.org/W2081115041","https://openalex.org/W2081629200","https://openalex.org/W2082979850","https://openalex.org/W2083627679","https://openalex.org/W2084220427","https://openalex.org/W2085328130","https://openalex.org/W2086144679","https://openalex.org/W2088172210","https://openalex.org/W2089082314","https://openalex.org/W2090226049","https://openalex.org/W2101859810","https://openalex.org/W2118733942","https://openalex.org/W2119683782","https://openalex.org/W2127587768","https://openalex.org/W2128366838","https://openalex.org/W2131414694","https://openalex.org/W2131876261","https://openalex.org/W2143331398","https://openalex.org/W2147550296","https://openalex.org/W2147934034","https://openalex.org/W2148607448","https://openalex.org/W2160345685","https://openalex.org/W2165047318","https://openalex.org/W2186911182","https://openalex.org/W2253146626","https://openalex.org/W2313594305","https://openalex.org/W4240132395","https://openalex.org/W4240629327","https://openalex.org/W6670696142","https://openalex.org/W6675337790","https://openalex.org/W6678886631","https://openalex.org/W6679371841","https://openalex.org/W6681867550","https://openalex.org/W6684695916","https://openalex.org/W6687063573"],"related_works":["https://openalex.org/W2044264814","https://openalex.org/W2015076784","https://openalex.org/W2088950084","https://openalex.org/W2035906232","https://openalex.org/W2049911257","https://openalex.org/W2035435589","https://openalex.org/W2315681052","https://openalex.org/W2411581817","https://openalex.org/W1966687443","https://openalex.org/W2113761414"],"abstract_inverted_index":{"A":[0],"folate":[1],"enzyme,":[2],"FDH":[3,45,148,177,202,206,241],"(10-formyltetrahydrofolate":[4],"dehydrogenase;":[5],"EC":[6],"1.5.1.6),":[7],"is":[8,24,31,76,129,172,231],"not":[9,70],"a":[10,232],"typical":[11],"tumour":[12],"suppressor,":[13],"but":[14,169],"it":[15,23],"has":[16],"two":[17],"basic":[18],"characteristics":[19],"of":[20,44,61,98,108,125,140,181,188,201,205,218,228,240],"one,":[21],"i.e.":[22],"down-regulated":[25],"in":[26,46,93,121,137,151,158,165,207,236,243],"tumours":[27],"and":[28,54,63,106,156,163,186],"its":[29,64],"expression":[30,43,187,242],"selectively":[32],"cytotoxic":[33],"to":[34,134,175,183,238],"cancer":[35,49,246],"cells.":[36,95,123,247],"We":[37,143],"have":[38,144],"recently":[39],"shown":[40,146],"that":[41,56,86,147,226],"ectopic":[42],"A549":[47,94],"lung":[48],"cells":[50,211,221],"induces":[51],"G1":[52],"arrest":[53],"apoptosis":[55,75,136],"was":[57,69,197,222],"accompanied":[58],"by":[59,111],"elevation":[60,149],"p53":[62,99,109,117,152,160,182,208,244],"downstream":[65,234],"target,":[66],"p21.":[67],"It":[68],"known,":[71],"however,":[72],"whether":[73],"FDH-induced":[74,87,119],"p53-dependent":[77,92,229],"or":[78],"not.":[79],"In":[80],"the":[81,126,138,159,166,184,189],"present":[82],"study,":[83],"we":[84],"report":[85],"suppressor":[88],"effects":[89],"are":[90],"strictly":[91,173],"Both":[96],"knockdown":[97],"using":[100],"an":[101,132],"RNAi":[102],"(RNA":[103],"interference)":[104],"approach":[105],"disabling":[107],"function":[110],"dominant-negative":[112],"inhibition":[113],"with":[114,131],"R175H":[115],"mutant":[116],"prevented":[118],"cytotoxicity":[120],"these":[122],"Ablation":[124],"FDH-suppressor":[127],"effect":[128],"associated":[130],"inability":[133],"activate":[135],"absence":[139],"functional":[141,209,245],"p53.":[142],"also":[145],"results":[150],"phosphorylation":[153],"at":[154],"Ser-6":[155,171],"Ser-20":[157],"transactivation":[161],"domain,":[162,168],"Ser-392":[164],"C-terminal":[167],"only":[170],"required":[174],"mediate":[176],"effects.":[178],"Also,":[179],"translocation":[180],"nuclei":[185],"pro-apoptotic":[190],"protein":[191],"PUMA":[192],"(Bcl2":[193],"binding":[194],"component":[195],"3)":[196],"observed":[198],"after":[199],"induction":[200,239],"expression.":[203],"Elevation":[204],"HCT116":[210,220],"induced":[212],"strong":[213],"growth":[214,217],"inhibition,":[215],"while":[216],"p53-deficient":[219],"unaffected.":[223],"This":[224],"implies":[225],"activation":[227],"pathways":[230],"general":[233],"mechanism":[235],"response":[237]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
