{"id":"https://openalex.org/W2091498722","doi":"https://doi.org/10.1016/j.freeradbiomed.2008.05.025","title":"Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide","display_name":"Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide","publication_year":2008,"publication_date":"2008-06-07","ids":{"openalex":"https://openalex.org/W2091498722","doi":"https://doi.org/10.1016/j.freeradbiomed.2008.05.025","mag":"2091498722","pmid":"https://pubmed.ncbi.nlm.nih.gov/18572022"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2008.05.025","doi":"https://doi.org/10.1016/j.freeradbiomed.2008.05.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2008.05.025","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033725058","display_name":"Antti J. V\u00e4\u00e4n\u00e4nen","orcid":"https://orcid.org/0000-0003-2385-7448","observed_orcids":["https://orcid.org/0000-0003-2385-7448"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antti J. V\u00e4\u00e4n\u00e4nen","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland","The Brain laboratory, Department of Biological and Environmental Sciences, P.O. Box 65, FIN-00014 University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"The Brain laboratory, Department of Biological and Environmental Sciences, P.O. Box 65, FIN-00014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005476134","display_name":"Pertteli Salmenper\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pertteli Salmenper\u00e4","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042103616","display_name":"Mika Hukkanen","orcid":"https://orcid.org/0000-0001-9687-9571","observed_orcids":["https://orcid.org/0000-0001-9687-9571"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mika Hukkanen","raw_affiliation_strings":["Department of Anatomy, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028796924","display_name":"Katrina M. Miranda","orcid":"https://orcid.org/0000-0002-9175-5091","observed_orcids":["https://orcid.org/0000-0002-9175-5091"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina M. Miranda","raw_affiliation_strings":["Department of Chemistry, University of Arizona, P.O. Box 210041, Tucson, AZ 85721-0041, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Arizona, P.O. Box 210041, Tucson, AZ 85721-0041, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014638310","display_name":"Ari L.J. Harjula","orcid":"https://orcid.org/0000-0001-6691-3636","observed_orcids":["https://orcid.org/0000-0001-6691-3636"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ari Harjula","raw_affiliation_strings":["Cell Therapy Research Consortium, Helsinki University Central Hospital, 3rd Department of Surgery, P.O. Box 340, FIN-00029 HUS, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Research Consortium, Helsinki University Central Hospital, 3rd Department of Surgery, P.O. Box 340, FIN-00029 HUS, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050053403","display_name":"Pekka Veli Rauhala","orcid":"https://orcid.org/0000-0003-2036-3522","observed_orcids":["https://orcid.org/0000-0003-2036-3522"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pekka Rauhala","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082077763","display_name":"Esko M Kankuri","orcid":"https://orcid.org/0000-0002-2193-8773","observed_orcids":["https://orcid.org/0000-0002-2193-8773"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Esko Kankuri","raw_affiliation_strings":["Cell Therapy Research Consortium, Helsinki University Central Hospital, 3rd Department of Surgery, P.O. Box 340, FIN-00029 HUS, Finland","Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Research Consortium, Helsinki University Central Hospital, 3rd Department of Surgery, P.O. Box 340, FIN-00029 HUS, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedicine, Biomedicum Helsinki, P.O. Box 63, FIN-00014 University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082077763"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":1.1397,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.75624928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"45","issue":"6","first_page":"749","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.09910000115633011,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nitroxyl","display_name":"nitroxyl","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endogenous-nitric-oxide","display_name":"endogenous nitric oxide","score":0.7839999794960022},{"id":"https://openalex.org/keywords/irreversible-enzyme-inhibition","display_name":"irreversible enzyme inhibition","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cysteine-protease","display_name":"cysteine protease","score":0.9020000100135803},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.699999988079071},{"id":"https://openalex.org/keywords/angeli-s-salt","display_name":"Angeli's salt","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dea-no","display_name":"DEA/NO","score":0.8759999871253967},{"id":"https://openalex.org/keywords/papain","display_name":"papain","score":0.9390000104904175},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.7829999923706055},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7720000147819519},{"id":"https://openalex.org/keywords/active-site-cysteine","display_name":"active site cysteine","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2776142628","wikidata":"https://www.wikidata.org/wiki/Q2919470","display_name":"Nitroxyl","level":2,"score":0.7962871789932251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7427821159362793},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6607872247695923},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6318753957748413},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.4188447892665863},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.2807122468948364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2529428005218506},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22076839208602905},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11201518774032593}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009589","descriptor_name":"Nitrogen Oxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2008.05.025","doi":"https://doi.org/10.1016/j.freeradbiomed.2008.05.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2008.05.025","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:18572022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18572022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W172242129","https://openalex.org/W1484675846","https://openalex.org/W1488020481","https://openalex.org/W1547781918","https://openalex.org/W1964058023","https://openalex.org/W1972297823","https://openalex.org/W1985289402","https://openalex.org/W1987862298","https://openalex.org/W1998879311","https://openalex.org/W2003946735","https://openalex.org/W2006172842","https://openalex.org/W2008448580","https://openalex.org/W2032841110","https://openalex.org/W2036551340","https://openalex.org/W2037621947","https://openalex.org/W2041206896","https://openalex.org/W2059349192","https://openalex.org/W2062055145","https://openalex.org/W2062445457","https://openalex.org/W2062483277","https://openalex.org/W2065494054","https://openalex.org/W2067821736","https://openalex.org/W2070625731","https://openalex.org/W2070820427","https://openalex.org/W2087042403","https://openalex.org/W2125380292","https://openalex.org/W2128635872","https://openalex.org/W2167712347","https://openalex.org/W2169232518","https://openalex.org/W2322243747","https://openalex.org/W2951552442","https://openalex.org/W3139190200"],"related_works":["https://openalex.org/W2037621947","https://openalex.org/W2112884164","https://openalex.org/W2293795909","https://openalex.org/W2892224459","https://openalex.org/W1208724953","https://openalex.org/W2507304015","https://openalex.org/W2041071737","https://openalex.org/W2077472996","https://openalex.org/W1997488413","https://openalex.org/W1973138891"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
