{"id":"https://openalex.org/W2091385166","doi":"https://doi.org/10.4161/auto.32170","title":"A mitochondrial-associated link between an effector caspase and autophagic flux","display_name":"A mitochondrial-associated link between an effector caspase and autophagic flux","publication_year":2014,"publication_date":"2014-08-13","ids":{"openalex":"https://openalex.org/W2091385166","doi":"https://doi.org/10.4161/auto.32170","mag":"2091385166","pmid":"https://pubmed.ncbi.nlm.nih.gov/25126735","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4198371"},"language":"en","primary_location":{"id":"doi:10.4161/auto.32170","doi":"https://doi.org/10.4161/auto.32170","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.32170","pdf_url":null,"source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4161/auto.32170","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084754178","display_name":"Lindsay DeVorkin","orcid":"https://orcid.org/0000-0003-2787-5387","observed_orcids":["https://orcid.org/0000-0003-2787-5387"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lindsay DeVorkin","raw_affiliation_strings":["The Genome Sciences Centre; BC Cancer Agency; Vancouver, BC Canada; Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, BC Canada","BC Cancer Agency","Burnaby, BC Canada","Department of Molecular Biology and Biochemistry","Simon Fraser University","The Genome Sciences Centre","Vancouver, BC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genome Sciences Centre; BC Cancer Agency; Vancouver, BC Canada; Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, BC Canada","institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I18014758"]},{"raw_affiliation_string":"BC Cancer Agency","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Burnaby, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"The Genome Sciences Centre","institution_ids":[]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018920739","display_name":"Sharon M. Gorski","orcid":"https://orcid.org/0000-0002-3821-8289","observed_orcids":["https://orcid.org/0000-0002-3821-8289"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sharon M Gorski","raw_affiliation_strings":["The Genome Sciences Centre; BC Cancer Agency; Vancouver, BC Canada; Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, BC Canada","BC Cancer Agency","Burnaby, BC Canada","Department of Molecular Biology and Biochemistry","Simon Fraser University","The Genome Sciences Centre","Vancouver, BC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genome Sciences Centre; BC Cancer Agency; Vancouver, BC Canada; Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, BC Canada","institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I18014758"]},{"raw_affiliation_string":"BC Cancer Agency","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Burnaby, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"The Genome Sciences Centre","institution_ids":[]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018920739"],"corresponding_institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I18014758"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"10","first_page":"1866","last_page":"1867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/effector-caspases","display_name":"effector caspases","score":0.9750000238418579},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.9559999704360962},{"id":"https://openalex.org/keywords/adenine-nucleotide-translocator","display_name":"adenine nucleotide translocase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/starvation-induced-autophagy","display_name":"starvation-induced autophagy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/oogenesis","display_name":"oogenesis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mitochondrial-network","display_name":"mitochondrial network","score":0.6069999933242798},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7170000076293945},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.7570000290870667},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.897524356842041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8474236726760864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.823539137840271},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7224355936050415},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6833425164222717},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.5966493487358093},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5913347005844116},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5096447467803955},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.503349244594574},{"id":"https://openalex.org/C155863897","wikidata":"https://www.wikidata.org/wiki/Q14913269","display_name":"Caspase 2","level":5,"score":0.49418118596076965},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.45671311020851135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22191748023033142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09023228287696838},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059208184480667114},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009866","descriptor_name":"Oogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053470","descriptor_name":"Caspases, Effector","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4161/auto.32170","doi":"https://doi.org/10.4161/auto.32170","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.32170","pdf_url":null,"source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4198371","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4198371/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4198371/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Text"},{"id":"pmid:25126735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25126735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/auto.32170","doi":"https://doi.org/10.4161/auto.32170","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.32170","pdf_url":null,"source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G109972196","display_name":null,"funder_award_id":"MOP78882","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091385166.pdf","grobid_xml":"https://content.openalex.org/works/W2091385166.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2121222036","https://openalex.org/W2091581755","https://openalex.org/W2311943621","https://openalex.org/W2010758581","https://openalex.org/W2044515182","https://openalex.org/W2310988694","https://openalex.org/W2019644987","https://openalex.org/W2887310485","https://openalex.org/W2994895262","https://openalex.org/W7098111261"],"abstract_inverted_index":{"It":[0],"has":[1],"become":[2],"evident":[3],"that":[4,26,72],"caspases":[5,18],"function":[6],"in":[7,11,19,68,86,105],"nonapoptotic":[8],"cellular":[9],"processes":[10],"addition":[12],"to":[13,33,48,90],"the":[14,27,34,51,57],"canonical":[15],"role":[16],"for":[17],"apoptotic":[20],"cell":[21],"death.":[22],"We":[23,70],"recently":[24],"demonstrated":[25],"Drosophila":[28],"effector":[29],"caspase":[30],"Dcp-1":[31,46,82],"localizes":[32],"mitochondria":[35],"and":[36,65,81],"positively":[37],"regulates":[38],"starvation-induced":[39],"autophagic":[40,79],"flux":[41],"during":[42],"mid-oogenesis.":[43],"Loss":[44],"of":[45,50,56,78,98,103],"leads":[47],"elongation":[49],"mitochondrial":[52,99],"network,":[53],"increased":[54,62],"levels":[55],"adenine":[58],"nucleotide":[59],"translocase":[60],"sesB,":[61],"ATP":[63],"levels,":[64],"a":[66,75,87,95],"reduction":[67],"autophagy.":[69],"found":[71],"sesB":[73,85],"is":[74],"negative":[76],"regulator":[77],"flux,":[80],"interacts":[83],"with":[84],"nonproteolytic":[88],"manner":[89],"regulate":[91],"its":[92],"stability,":[93],"uncovering":[94],"novel":[96],"mechanism":[97],"associated,":[100],"caspase-mediated":[101],"regulation":[102],"autophagy":[104],"vivo.":[106]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}