{"id":"https://openalex.org/W2091362072","doi":"https://doi.org/10.1038/344868a0","title":"Activin is a nerve cell survival molecule","display_name":"Activin is a nerve cell survival molecule","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W2091362072","doi":"https://doi.org/10.1038/344868a0","mag":"2091362072","pmid":"https://pubmed.ncbi.nlm.nih.gov/2330043"},"language":"en","primary_location":{"id":"doi:10.1038/344868a0","doi":"https://doi.org/10.1038/344868a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/344868a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101896253","display_name":"David A. Schubert","orcid":"https://orcid.org/0000-0002-1190-7623","observed_orcids":["https://orcid.org/0000-0002-1190-7623"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Schubert","raw_affiliation_strings":["Salk Institute, La Jolla, California 92037","The Salk Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Salk Institute, La Jolla, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076764999","display_name":"Hideo Kimura","orcid":"https://orcid.org/0000-0002-6069-0475","observed_orcids":["https://orcid.org/0000-0002-6069-0475"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Kimura","raw_affiliation_strings":["The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","The Salk Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Salk Institute, La Jolla, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049404405","display_name":"M LaCorbiere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. LaCorbiere","raw_affiliation_strings":["The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","The Salk Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Salk Institute, La Jolla, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110087639","display_name":"Joan M. Vaughan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Vaughan","raw_affiliation_strings":["The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","The Salk Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Salk Institute, La Jolla, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009094285","display_name":"David Karr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Karr","raw_affiliation_strings":["The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","The Salk Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Salk Institute, La Jolla, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111720911","display_name":"Wolfgang H. Fischer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. H. Fischer","raw_affiliation_strings":["The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","The Salk Institute, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Salk Institute, La Jolla, USA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":10.0368,"has_fulltext":false,"cited_by_count":293,"citation_normalized_percentile":{"value":0.99075391,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"344","issue":"6269","first_page":"868","last_page":"870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":1.0},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.847000002861023},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9520000219345093},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.515999972820282},{"id":"https://openalex.org/keywords/rat-eye","display_name":"rat eye","score":0.45100000500679016},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C68710172","wikidata":"https://www.wikidata.org/wiki/Q14906191","display_name":"Ciliary neurotrophic factor","level":4,"score":0.7914289236068726},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6594268083572388},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.5760184526443481},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5486491918563843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5197739005088806},{"id":"https://openalex.org/C26805974","wikidata":"https://www.wikidata.org/wiki/Q7117837","display_name":"P19 cell","level":5,"score":0.4416930079460144},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.43759816884994507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43515104055404663},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3473094403743744},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.2732926607131958},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.21655291318893433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12802177667617798},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.0800391137599945},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013724","descriptor_name":"Teratoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/344868a0","doi":"https://doi.org/10.1038/344868a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/344868a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:2330043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2330043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W210896705","https://openalex.org/W1430328139","https://openalex.org/W1502751847","https://openalex.org/W1513698169","https://openalex.org/W1551105307","https://openalex.org/W1807295484","https://openalex.org/W1858019981","https://openalex.org/W1966092687","https://openalex.org/W1969105500","https://openalex.org/W1998225973","https://openalex.org/W2003932465","https://openalex.org/W2023846059","https://openalex.org/W2024683111","https://openalex.org/W2033367566","https://openalex.org/W2045217277","https://openalex.org/W2050620572","https://openalex.org/W2055922123","https://openalex.org/W2057835832","https://openalex.org/W2058852380","https://openalex.org/W2060889469","https://openalex.org/W2062745751","https://openalex.org/W2064538264","https://openalex.org/W2065982341","https://openalex.org/W2077088537","https://openalex.org/W2081093385","https://openalex.org/W2081689397","https://openalex.org/W2089389307","https://openalex.org/W2089543118","https://openalex.org/W2121119720"],"related_works":["https://openalex.org/W2390613532","https://openalex.org/W2094941012","https://openalex.org/W2102484734","https://openalex.org/W7098278248","https://openalex.org/W296365624","https://openalex.org/W2134489721","https://openalex.org/W2057360448","https://openalex.org/W2018068734","https://openalex.org/W1995055477","https://openalex.org/W1971867070"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}