{"id":"https://openalex.org/W2091274587","doi":"https://doi.org/10.1016/0022-4804(76)90168-2","title":"Effect of induced thrombocytopenia on experimental circulatory shock","display_name":"Effect of induced thrombocytopenia on experimental circulatory shock","publication_year":1976,"publication_date":"1976-12-01","ids":{"openalex":"https://openalex.org/W2091274587","doi":"https://doi.org/10.1016/0022-4804(76)90168-2","mag":"2091274587","pmid":"https://pubmed.ncbi.nlm.nih.gov/1011824"},"language":"en","primary_location":{"id":"doi:10.1016/0022-4804(76)90168-2","doi":"https://doi.org/10.1016/0022-4804(76)90168-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-4804(76)90168-2","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan M. Lefer","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069195632","display_name":"G. Alan Bridenbaugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.Alan Bridenbaugh","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111791442","display_name":"John T. Flynn","orcid":"https://orcid.org/0009-0007-5858-6613","observed_orcids":["https://orcid.org/0009-0007-5858-6613"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Flynn","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110287816"],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.8015,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.84674064,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":"429","last_page":"436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/shock","display_name":"shock","score":0.9480000138282776},{"id":"https://openalex.org/keywords/splanchnic-artery-occlusion","display_name":"splanchnic artery occlusion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/platelet-release","display_name":"platelet release","score":0.47999998927116394},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mdf","display_name":"MDF","score":0.4869999885559082},{"id":"https://openalex.org/keywords/portal-vein-pressure","display_name":"portal pressure","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.7630976438522339},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7168084383010864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6363994479179382},{"id":"https://openalex.org/C2775849017","wikidata":"https://www.wikidata.org/wiki/Q4121920","display_name":"Splanchnic","level":3,"score":0.5447824597358704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4862293303012848},{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.46707016229629517},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.46453744173049927},{"id":"https://openalex.org/C2781046184","wikidata":"https://www.wikidata.org/wiki/Q367570","display_name":"Superior mesenteric artery","level":2,"score":0.4562460482120514},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4334310293197632},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4264804422855377},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4239046573638916},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.41127991676330566},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36514294147491455},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.26480501890182495},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.22452899813652039},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.18430066108703613}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011460","descriptor_name":"Prostaglandins F","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-4804(76)90168-2","doi":"https://doi.org/10.1016/0022-4804(76)90168-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-4804(76)90168-2","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},{"id":"pmid:1011824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1011824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of surgical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306165","display_name":"Spinal Muscular Atrophy Foundation","ror":"https://ror.org/02hkvad16"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W24678033","https://openalex.org/W211083069","https://openalex.org/W1506043065","https://openalex.org/W1987865546","https://openalex.org/W1989001705","https://openalex.org/W1992650719","https://openalex.org/W2014986415","https://openalex.org/W2029487918","https://openalex.org/W2032195837","https://openalex.org/W2059508538","https://openalex.org/W2075323162","https://openalex.org/W2078405962","https://openalex.org/W2084671739","https://openalex.org/W2172091239","https://openalex.org/W2173711581","https://openalex.org/W2237495608","https://openalex.org/W2267580816","https://openalex.org/W2397491545","https://openalex.org/W2399392129","https://openalex.org/W2410907125","https://openalex.org/W2411446877","https://openalex.org/W2412955207","https://openalex.org/W2414005623","https://openalex.org/W2415251542","https://openalex.org/W2417786789","https://openalex.org/W4300467858"],"related_works":["https://openalex.org/W2433521320","https://openalex.org/W211083069","https://openalex.org/W2070155894","https://openalex.org/W2370609967","https://openalex.org/W3212058511","https://openalex.org/W2412250486","https://openalex.org/W2030790802","https://openalex.org/W3087771389","https://openalex.org/W2399793608","https://openalex.org/W841727126"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}