{"id":"https://openalex.org/W2091225809","doi":"https://doi.org/10.1056/nejm197908023010507","title":"Discordance between Plasma Calcitonin and Tumor-Cell Mass in Medullary Thyroid Carcinoma","display_name":"Discordance between Plasma Calcitonin and Tumor-Cell Mass in Medullary Thyroid Carcinoma","publication_year":1979,"publication_date":"1979-08-02","ids":{"openalex":"https://openalex.org/W2091225809","doi":"https://doi.org/10.1056/nejm197908023010507","mag":"2091225809","pmid":"https://pubmed.ncbi.nlm.nih.gov/449992"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197908023010507","doi":"https://doi.org/10.1056/nejm197908023010507","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197908023010507","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108200442","display_name":"Donald L. Trump","orcid":"https://orcid.org/0009-0003-1744-6412","observed_orcids":["https://orcid.org/0009-0003-1744-6412"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald L. Trump","raw_affiliation_strings":["The Johns Hopkins Oncology Center and the departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore (address reprint requests to Dr. Trump at The Johns Hopkins Oncology Center, 600 N. Wolfe St., Baltimore, MD 21205)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Oncology Center and the departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore (address reprint requests to Dr. Trump at The Johns Hopkins Oncology Center, 600 N. Wolfe St., Baltimore, MD 21205)","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015179016","display_name":"Geoffrey Mendelsohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Mendelsohn","raw_affiliation_strings":["The Johns Hopkins Oncology Center and the departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore (address reprint requests to Dr. Trump at The Johns Hopkins Oncology Center, 600 N. Wolfe St., Baltimore, MD 21205)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Oncology Center and the departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore (address reprint requests to Dr. Trump at The Johns Hopkins Oncology Center, 600 N. Wolfe St., Baltimore, MD 21205)","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Baylin","raw_affiliation_strings":["The Johns Hopkins Oncology Center and the departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore (address reprint requests to Dr. Trump at The Johns Hopkins Oncology Center, 600 N. Wolfe St., Baltimore, MD 21205)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Oncology Center and the departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore (address reprint requests to Dr. Trump at The Johns Hopkins Oncology Center, 600 N. Wolfe St., Baltimore, MD 21205)","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3892,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.92044444,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"301","issue":"5","first_page":"253","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasma-calcitonin","display_name":"plasma calcitonin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tumor-burden","display_name":"tumor burden","score":0.6380000114440918},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-biology","display_name":"tumor biology","score":0.6269999742507935},{"id":"https://openalex.org/keywords/hemithyroidectomy","display_name":"hemithyroidectomy","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.9485253095626831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8731781840324402},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.7479032278060913},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7387866973876953},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.703849732875824},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.7028388381004333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5417289733886719},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4537721574306488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4489542245864868},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4436095952987671},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43314722180366516},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4172343909740448}],"mesh":[{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197908023010507","doi":"https://doi.org/10.1056/nejm197908023010507","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197908023010507","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:449992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/449992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W133676264","https://openalex.org/W1967304777","https://openalex.org/W1979024960","https://openalex.org/W2030713454","https://openalex.org/W2044688317","https://openalex.org/W2060512249","https://openalex.org/W2124663059","https://openalex.org/W2322224647","https://openalex.org/W2339150538","https://openalex.org/W2340761814"],"related_works":["https://openalex.org/W2126171430","https://openalex.org/W2054756244","https://openalex.org/W2400509532","https://openalex.org/W2320522935","https://openalex.org/W2171325971","https://openalex.org/W2049160664","https://openalex.org/W1982387933","https://openalex.org/W2401930860","https://openalex.org/W2059445096","https://openalex.org/W7097880544"],"abstract_inverted_index":{"MEDULLARY":[0],"thyroid":[1,32,88,96],"carcinomas":[2],"always":[3],"secrete":[4],"calcitonin,":[5],"leading":[6],"to":[7,92],"an":[8,63],"increased":[9],"plasma":[10,14,36,51],"hormone":[11],"concentration.1":[12],"The":[13],"calcitonin":[15,37,52],"concentration":[16,53],"usually":[17],"correlates":[18],"with":[19,30,41],"the":[20,46,84],"clinical":[21],"extent":[22],"of":[23,59,74,86],"disease.2":[24],"This":[25],"article":[26],"describes":[27],"a":[28,70,87,94],"patient":[29],"medullary":[31,95],"carcinoma":[33],"in":[34],"whom":[35],"did":[38],"not":[39],"correlate":[40],"estimated":[42],"tumor":[43,47,60,76],"burden.":[44],"Although":[45],"had":[48],"metastasized":[49],"widely,":[50],"was":[54],"unexpectedly":[55],"low.":[56],"Immunohistochemical":[57],"analysis":[58],"tissue":[61],"provides":[62],"explanation":[64],"for":[65],"this":[66],"observation":[67],"and":[68],"illustrates":[69],"potentially":[71],"important":[72],"feature":[73],"human":[75],"biology.Case":[77],"ReportA":[78],"46-year-old":[79],"man":[80],"underwent":[81],"hemithyroidectomy":[82],"after":[83],"discovery":[85],"nodule,":[89],"which":[90],"proved":[91],"be":[93],"carcinoma.":[97],".":[98,99,100]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
