{"id":"https://openalex.org/W2091106598","doi":"https://doi.org/10.3164/jcbn.2008008","title":"Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation","display_name":"Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2091106598","doi":"https://doi.org/10.3164/jcbn.2008008","mag":"2091106598","pmid":"https://pubmed.ncbi.nlm.nih.gov/18231630","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2212348"},"language":"en","primary_location":{"id":"doi:10.3164/jcbn.2008008","doi":"https://doi.org/10.3164/jcbn.2008008","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.2008008","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/42/1/42_2008008/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jcbn/42/1/42_2008008/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110593874","display_name":"Midori Natsume","orcid":"https://orcid.org/0009-0004-5819-1150","observed_orcids":["https://orcid.org/0009-0004-5819-1150"]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Midori Natsume","raw_affiliation_strings":["Food and Health Laboratories, Meiji Seika Kaisha. Ltd., 5-3-1 Chiyoda, Sakado-shi, Saitama 350-0289, Japan","Food and Health Laboratories, Meiji Seika Kaisha. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food and Health Laboratories, Meiji Seika Kaisha. Ltd., 5-3-1 Chiyoda, Sakado-shi, Saitama 350-0289, Japan","institution_ids":["https://openalex.org/I4405275510"]},{"raw_affiliation_string":"Food and Health Laboratories, Meiji Seika Kaisha. Ltd","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067577792","display_name":"Naomi Osakabe","orcid":"https://orcid.org/0000-0001-8159-7053","observed_orcids":["https://orcid.org/0000-0001-8159-7053"]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Osakabe","raw_affiliation_strings":["Food and Health Laboratories, Meiji Seika Kaisha. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food and Health Laboratories, Meiji Seika Kaisha. Ltd","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057450331","display_name":"Akiko Yasuda","orcid":"https://orcid.org/0000-0001-9994-1414","observed_orcids":["https://orcid.org/0000-0001-9994-1414"]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Yasuda","raw_affiliation_strings":["Food and Health Laboratories, Meiji Seika Kaisha. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food and Health Laboratories, Meiji Seika Kaisha. Ltd","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111822748","display_name":"Toshihiko Osawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Osawa","raw_affiliation_strings":["Graduate School of Bioagricultural Sciences, Nagoya University","Graduate School of Bioagricultural Sciences, Nagoya Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Bioagricultural Sciences, Nagoya University","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Graduate School of Bioagricultural Sciences, Nagoya Univ","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103111832","display_name":"Junji Terao","orcid":"https://orcid.org/0009-0008-2424-6300","observed_orcids":["https://orcid.org/0009-0008-2424-6300"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junji Terao","raw_affiliation_strings":["Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima","institution_ids":["https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110593874"],"corresponding_institution_ids":["https://openalex.org/I4405275510"],"apc_list":null,"apc_paid":null,"fwci":0.3545,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.56048193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"42","issue":"1","first_page":"50","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.2272000014781952,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epicatechin","display_name":"epicatechin","score":0.8019999861717224},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tyrosine-nitration","display_name":"tyrosine nitration","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/glucuronide-conjugates","display_name":"glucuronide conjugates","score":0.7559999823570251},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7749999761581421},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.9473099708557129},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7904595732688904},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.7803341150283813},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5690504312515259},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4962776303291321},{"id":"https://openalex.org/C2779385521","wikidata":"https://www.wikidata.org/wiki/Q412383","display_name":"Nitrotyrosine","level":4,"score":0.47453629970550537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45114609599113464},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.44181153178215027},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41705283522605896},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.1545882523059845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12810835242271423},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10344627499580383},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3164/jcbn.2008008","doi":"https://doi.org/10.3164/jcbn.2008008","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.2008008","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/42/1/42_2008008/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},{"id":"pmid:18231630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18231630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical biochemistry and nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2212348","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2212348/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Biochem Nutr","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.5155","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.5155","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9c/0f/J_Clin_Biochem_Nutr_2008_Jan_28_42(1)_50-53.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3164/jcbn.2008008","doi":"https://doi.org/10.3164/jcbn.2008008","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.2008008","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/42/1/42_2008008/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091106598.pdf","grobid_xml":"https://content.openalex.org/works/W2091106598.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1589162257","https://openalex.org/W1853889911","https://openalex.org/W1951936518","https://openalex.org/W1965033651","https://openalex.org/W1974277761","https://openalex.org/W1987829920","https://openalex.org/W1996186591","https://openalex.org/W2002797577","https://openalex.org/W2010257889","https://openalex.org/W2019622238","https://openalex.org/W2020766753","https://openalex.org/W2023766975","https://openalex.org/W2023904752","https://openalex.org/W2036573205","https://openalex.org/W2043938604","https://openalex.org/W2044212253","https://openalex.org/W2048182776","https://openalex.org/W2064569606","https://openalex.org/W2085268580","https://openalex.org/W2105234557","https://openalex.org/W2108025709","https://openalex.org/W2149322480","https://openalex.org/W2168191336","https://openalex.org/W2209359394"],"related_works":["https://openalex.org/W7096848758","https://openalex.org/W2064569606","https://openalex.org/W2042322971","https://openalex.org/W2091142550","https://openalex.org/W2026789068","https://openalex.org/W2155382971","https://openalex.org/W1996186591","https://openalex.org/W2020766753","https://openalex.org/W257776770","https://openalex.org/W2084223650"],"abstract_inverted_index":{"Previously,":[0],"we":[1],"identified":[2],"four":[3],"metabolites":[4,44,101],"of":[5,32,42,47,54,85,102],"(-)-epicatechin":[6,89,103],"in":[7,81],"blood":[8],"and":[9,17,57,64,66],"urine:":[10],"(-)-epicatechin-3'-O-glucuronide":[11],"(E3'G),":[12],"4'-O-methyl-(-)-epicatechin-3'-O-glucuronide":[13],"(4'ME3'G),":[14],"(-)-epicatechin-7-O-glucuronide":[15],"(E7G),":[16],"3'-O-methyl-(-)-epicatechin-7-O-glucuronide":[18],"(3'ME7G)":[19],"(Natsume":[20],"et":[21],"al.":[22],"Free":[23],"Radical":[24],"Biol.":[25],"Med.":[26],"34,":[27],"840-849,":[28],"2003).":[29],"The":[30],"aim":[31],"the":[33,39,82,100],"current":[34],"study":[35],"was":[36],"to":[37,111],"compare":[38],"antioxidative":[40,105],"activities":[41],"these":[43,75],"with":[45],"that":[46,74,99],"their":[48],"parent":[49],"compound.":[50],"After":[51],"oral":[52],"administration":[53],"(-)-epicatechin,":[55],"E3'G":[56,87],"4'ME3'G":[58],"were":[59],"isolated":[60,68],"from":[61,69],"human":[62],"urine,":[63],"E7G":[65,91],"3'ME7G":[67],"rat":[70],"urine.":[71],"We":[72],"found":[73],"compounds":[76],"inhibited":[77],"peroxynitrite-mediated":[78],"tyrosine":[79],"nitration,":[80],"following":[83],"order":[84],"potency:":[86],">":[88,90],"=":[92,94],"3'ME7G.":[93],"4'ME3'G.":[95],"These":[96],"results":[97],"demonstrate":[98],"retain":[104],"activity":[106],"on":[107],"peroxynitrite-induced":[108],"oxidative":[109],"damages":[110],"some":[112],"extent.":[113]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
