{"id":"https://openalex.org/W2091091069","doi":"https://doi.org/10.1210/endo.138.4.5074","title":"The Role of Transforming Growth Factor- in the Regulation of Estrogen Receptor Expression in the MCF-7 Breast Cancer Cell Line","display_name":"The Role of Transforming Growth Factor- in the Regulation of Estrogen Receptor Expression in the MCF-7 Breast Cancer Cell Line","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2091091069","doi":"https://doi.org/10.1210/endo.138.4.5074","mag":"2091091069","pmid":"https://pubmed.ncbi.nlm.nih.gov/9075708"},"language":"en","primary_location":{"id":"doi:10.1210/endo.138.4.5074","doi":"https://doi.org/10.1210/endo.138.4.5074","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.138.4.5074","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083283335","display_name":"Adriana Stoica","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Stoica","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011693896","display_name":"Miguel Saceda","orcid":"https://orcid.org/0000-0002-1564-3602","observed_orcids":["https://orcid.org/0000-0002-1564-3602"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Saceda","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042548323","display_name":"Amina Fakhro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amina Fakhro","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016907930","display_name":"Harrison B. Solomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harrison B. Solomon","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064956173","display_name":"Bradley D. Fenster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley D. Fenster","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062855220","display_name":"Mary Beth Martin","orcid":"https://orcid.org/0000-0001-7688-9158","observed_orcids":["https://orcid.org/0000-0001-7688-9158"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary Beth Martin","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062855220"],"corresponding_institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.1492,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.79367012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"138","issue":"4","first_page":"1498","last_page":"1505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9959999918937683},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/estradiol-binding","display_name":"estradiol binding","score":0.734000027179718},{"id":"https://openalex.org/keywords/receptor-half-life","display_name":"receptor half-life","score":0.6769999861717224},{"id":"https://openalex.org/keywords/estrogen-receptor-mrna","display_name":"estrogen receptor mRNA","score":0.6850000023841858},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ps2","display_name":"pS2","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6822094917297363},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.670009970664978},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6496267914772034},{"id":"https://openalex.org/C2780730277","wikidata":"https://www.wikidata.org/wiki/Q24744759","display_name":"Chloramphenicol acetyltransferase","level":5,"score":0.5935089588165283},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5668268203735352},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5006506443023682},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48905691504478455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4889620542526245},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4591834247112274},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4509701728820801},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4500300884246826},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.4462661147117615},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43812867999076843},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42446067929267883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36984479427337646},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2985009551048279},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.28648650646209717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18460655212402344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12254604697227478},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11561048030853271},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/endo.138.4.5074","doi":"https://doi.org/10.1210/endo.138.4.5074","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.138.4.5074","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/en.138.4.1498","doi":"https://doi.org/10.1210/en.138.4.1498","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.138.4.1498","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:9075708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9075708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6301766021","display_name":"GROWTH REGULATION AS TARGETS IN BREAST CANCER TREATMENT","funder_award_id":"U01CA051908","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1480232957","https://openalex.org/W1515380434","https://openalex.org/W1543387243","https://openalex.org/W1545795848","https://openalex.org/W1568802110","https://openalex.org/W1569704074","https://openalex.org/W1573821584","https://openalex.org/W1576667188","https://openalex.org/W1584215988","https://openalex.org/W1590119505","https://openalex.org/W1791368090","https://openalex.org/W1808371613","https://openalex.org/W1811094195","https://openalex.org/W1847098517","https://openalex.org/W1894632965","https://openalex.org/W1916260177","https://openalex.org/W1932528123","https://openalex.org/W1954929088","https://openalex.org/W1966165057","https://openalex.org/W1967850071","https://openalex.org/W1980968239","https://openalex.org/W1981756776","https://openalex.org/W1983649348","https://openalex.org/W1988925715","https://openalex.org/W1994560336","https://openalex.org/W1994937757","https://openalex.org/W1995136152","https://openalex.org/W1999162852","https://openalex.org/W1999186716","https://openalex.org/W2005830746","https://openalex.org/W2018579779","https://openalex.org/W2021263701","https://openalex.org/W2025714049","https://openalex.org/W2027623914","https://openalex.org/W2029545106","https://openalex.org/W2042480227","https://openalex.org/W2051877942","https://openalex.org/W2059153388","https://openalex.org/W2073865988","https://openalex.org/W2085310269","https://openalex.org/W2086730539","https://openalex.org/W2087821275","https://openalex.org/W2130535740","https://openalex.org/W2130826810","https://openalex.org/W2133011645","https://openalex.org/W2171523212"],"related_works":["https://openalex.org/W7098246913","https://openalex.org/W1963741882","https://openalex.org/W2102344606","https://openalex.org/W2031850558","https://openalex.org/W2081523368","https://openalex.org/W2012003246","https://openalex.org/W2087767016","https://openalex.org/W2033461320","https://openalex.org/W4247808711","https://openalex.org/W2171523212"],"abstract_inverted_index":{"The":[0,55,90],"role":[1],"of":[2,10,22,41,57,87,93,118,132,159,177,188,194,224,252,262,274],"transforming":[3],"growth":[4,244],"factor-beta1":[5],"(TGFbeta1)":[6],"in":[7,15,45,52,70,77,100,107,127,150,154,174,191],"the":[8,23,68,84,88,94,116,119,130,133,142,155,175,192,225,232,240,243,250],"regulation":[9],"estrogen":[11],"receptor":[12,58,134,264],"(ER)":[13],"expression":[14],"MCF-7":[16,275],"cells":[17,24,47,102,276],"was":[18,97,135,180],"investigated.":[19],"After":[20],"treatment":[21,148,236],"with":[25,80,111,237],"100":[26],"pM":[27],"TGFbeta1,":[28],"ER":[29,71,145,160,195,205,226,233,241,279],"protein":[30,44,51,72],"declined":[31],"by":[32,218,256,277],"about":[33],"30%":[34],"at":[35,165,198],"6":[36,166],"h":[37],"from":[38],"a":[39,75,151,171,186],"concentration":[40,56],"413.5":[42],"fmol/mg":[43,50],"control":[46,108,128],"to":[48,74,104,141],"289.5":[49],"treated":[53],"cells.":[54,109],"remained":[59],"suppressed":[60],"for":[61],"24":[62,169],"h.":[63,138,167,200],"Scatchard":[64],"analysis":[65],"demonstrated":[66,185,209],"that":[67,210,221,268],"decrease":[69,76,153,187],"corresponded":[73],"estradiol-binding":[78],"sites,":[79],"no":[81,247],"effect":[82,143,248],"on":[83,144,249,259],"binding":[85],"affinity":[86],"ER.":[89,120],"dissociation":[91],"constant":[92],"estradiol-ER":[95],"complex":[96],"0.117":[98],"nM":[99,106],"TGFbeta1-treated":[101,122],"compared":[103],"0.155":[105],"Treatment":[110],"TGFbeta1":[112,147,212,222,238,269],"did":[113],"not":[114,271],"influence":[115],"half-life":[117,131],"In":[121,139],"cells,":[123,129],"as":[124,126,254],"well":[125],"approximately":[136,189],"4":[137],"contrast":[140],"concentration,":[146,242],"resulted":[149],"greater":[152],"steady":[156],"state":[157],"level":[158,193],"messenger":[161,178],"RNA":[162,179],"(approximately":[163],"75%)":[164],"By":[168],"h,":[170],"small":[172],"recovery":[173],"amount":[176],"observed.":[181],"Transcription":[182],"run-on":[183],"experiments":[184],"70%":[190],"gene":[196,227],"transcription":[197,228],"3":[199],"Transient":[201],"transfections":[202],"using":[203],"an":[204],"promoter-chloramphenicol":[206],"acetyltransferase":[207,215],"construct":[208],"after":[211],"treatment,":[213],"chloramphenicol":[214],"activity":[216,251],"decreased":[217,239],"50%,":[219],"suggesting":[220,267],"inhibition":[223],"is":[229],"mediated":[230],"through":[231],"promoter.":[234],"Although":[235],"factor":[245],"had":[246],"ER,":[253],"measured":[255],"its":[257],"effects":[258],"estradiol":[260],"induction":[261],"progesterone":[263],"and":[265],"pS2,":[266],"does":[270],"inhibit":[272],"proliferation":[273],"blocking":[278],"activity.":[280]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
