{"id":"https://openalex.org/W2091024375","doi":"https://doi.org/10.1158/1538-7445.am2011-1282","title":"Abstract 1282: Phase I evaluation of STA-1474, a pro-drug of the novel HSP90 inhibitor STA-9090, in dogs with spontaneous cancer","display_name":"Abstract 1282: Phase I evaluation of STA-1474, a pro-drug of the novel HSP90 inhibitor STA-9090, in dogs with spontaneous cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2091024375","doi":"https://doi.org/10.1158/1538-7445.am2011-1282","mag":"2091024375"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-1282","doi":"https://doi.org/10.1158/1538-7445.am2011-1282","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1282","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021474295","display_name":"Cheryl A. London","orcid":"https://orcid.org/0000-0001-8563-1490","observed_orcids":["https://orcid.org/0000-0001-8563-1490"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl A. London","raw_affiliation_strings":["1Ohio State Univ., Columbus, OH","1Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075536148","display_name":"Misty D. Bear","orcid":"https://orcid.org/0000-0001-6072-7621","observed_orcids":["https://orcid.org/0000-0001-6072-7621"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Misty D. Bear","raw_affiliation_strings":["1Ohio State Univ., Columbus, OH","1Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085260686","display_name":"Jennifer McCleese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer McCleese","raw_affiliation_strings":["1Ohio State Univ., Columbus, OH","1Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Ohio State Univ., Columbus, OH","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"1Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035181510","display_name":"Kevin P. Foley","orcid":"https://orcid.org/0000-0001-5148-7689","observed_orcids":["https://orcid.org/0000-0001-5148-7689"]},"institutions":[{"id":"https://openalex.org/I4210158135","display_name":"Synta Pharmaceuticals (United States)","ror":"https://ror.org/00rkhrg48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin P. Foley","raw_affiliation_strings":["2Synta Pharmaceuticals Corp, Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Synta Pharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I4210158135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049060405","display_name":"Reji Paalangara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158135","display_name":"Synta Pharmaceuticals (United States)","ror":"https://ror.org/00rkhrg48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reji Paalangara","raw_affiliation_strings":["2Synta Pharmaceuticals Corp, Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Synta Pharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I4210158135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062079325","display_name":"Takayo Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158135","display_name":"Synta Pharmaceuticals (United States)","ror":"https://ror.org/00rkhrg48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takayo Inoue","raw_affiliation_strings":["2Synta Pharmaceuticals Corp, Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Synta Pharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I4210158135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508194","display_name":"Weiwen Ying","orcid":"https://orcid.org/0000-0002-5879-3782","observed_orcids":["https://orcid.org/0000-0002-5879-3782"]},"institutions":[{"id":"https://openalex.org/I4210158135","display_name":"Synta Pharmaceuticals (United States)","ror":"https://ror.org/00rkhrg48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiwen Ying","raw_affiliation_strings":["2Synta Pharmaceuticals Corp, Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Synta Pharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I4210158135"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088509963","display_name":"James Barsoum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158135","display_name":"Synta Pharmaceuticals (United States)","ror":"https://ror.org/00rkhrg48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Barsoum","raw_affiliation_strings":["2Synta Pharmaceuticals Corp, Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Synta Pharmaceuticals Corp, Lexington, MA","institution_ids":["https://openalex.org/I4210158135"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"1282","last_page":"1282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.8759999871253967},{"id":"https://openalex.org/keywords/canine-cancer","display_name":"canine cancer","score":0.6570000052452087},{"id":"https://openalex.org/keywords/spontaneous-tumors","display_name":"spontaneous tumors","score":0.6520000100135803},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mast-cell-disorders","display_name":"mast cell disease","score":0.6830000281333923},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7869162559509277},{"id":"https://openalex.org/C2777260799","wikidata":"https://www.wikidata.org/wiki/Q15637420","display_name":"Lethargy","level":2,"score":0.6373753547668457},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5836050510406494},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5346919894218445},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5256413221359253},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4885026216506958},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4782654047012329},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4562396705150604},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.4361473023891449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4202675223350525},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4143766760826111},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3952057659626007},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3366493582725525},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3015891909599304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28979742527008057}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-1282","doi":"https://doi.org/10.1158/1538-7445.am2011-1282","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1282","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004703923","https://openalex.org/W2335661796","https://openalex.org/W4234918343","https://openalex.org/W7096477214","https://openalex.org/W2268504878","https://openalex.org/W2172503981","https://openalex.org/W2889442226","https://openalex.org/W2144551737","https://openalex.org/W2571319611","https://openalex.org/W2189254184"],"abstract_inverted_index":{"Abstract":[0],"The":[1,35],"novel":[2],"water":[3],"soluble":[4],"compound":[5],"STA-1474":[6,53,72,181,213],"is":[7,210],"metabolized":[8],"to":[9,17,42,203],"STA-9090,":[10],"a":[11,61,92,152,168,186],"potent":[12],"HSP90":[13,207],"inhibitor":[14],"previously":[15],"shown":[16],"kill":[18],"canine":[19,197],"tumor":[20,27,85,120,204],"cell":[21,140],"lines":[22],"in":[23,29,54,65,102,118,135,164,185,221],"vitro":[24],"and":[25,46,50,84,109,122,147,198,206,214],"inhibit":[26],"growth":[28],"the":[30,38,48,194,233,238],"setting":[31],"of":[32,37,52,75,94,105,112,155,173,191,196,232,237],"murine":[33],"xenografts.":[34],"purpose":[36],"following":[39,127],"study":[40,177],"was":[41,60,116,162],"extend":[43],"these":[44],"observations":[45],"investigate":[47],"safety":[49],"efficacy":[51],"dogs":[55,67,90,136],"with":[56,68,91,137,201],"spontaneous":[57,69],"tumors.":[58],"This":[59,176],"Phase":[62],"1":[63],"trial":[64],"which":[66],"tumors":[70],"received":[71],"under":[73],"one":[74],"three":[76],"different":[77],"dosing":[78],"schemes.":[79],"Pharmacokinetics,":[80],"toxicities,":[81],"biomarker":[82],"changes,":[83],"responses":[86,132],"were":[87,96,99,133],"assessed.":[88],"Twenty-five":[89],"variety":[93],"cancers":[95,200],"enrolled.":[97],"Toxicities":[98],"primarily":[100],"gastrointestinal":[101],"nature":[103],"consisting":[104],"diarrhea,":[106],"vomiting,":[107],"inappetence":[108],"lethargy.":[110],"Upregulation":[111],"HSP70":[113],"protein":[114],"expression":[115],"noted":[117],"both":[119],"specimens":[121],"PBMCs":[123],"within":[124],"7":[125],"hours":[126],"drug":[128],"administration.":[129],"Measurable":[130],"objective":[131],"observed":[134],"malignant":[138],"mast":[139],"disease":[141,159],"(n=3),":[142],"osteosarcoma":[143],"(n=1),":[144,150],"melanoma":[145],"(n=1)":[146],"thyroid":[148],"carcinoma":[149],"for":[151,167,241],"response":[153],"rate":[154],"24%":[156],"(6/25).":[157],"Stable":[158],"(>10":[160],"weeks)":[161],"seen":[163],"3":[165],"dogs,":[166],"resultant":[169],"overall":[170],"biological":[171],"activity":[172,184,220],"36%":[174],"(9/25).":[175],"provides":[178],"evidence":[179],"that":[180,212],"exhibits":[182],"biologic":[183],"relevant":[187],"large":[188],"animal":[189],"model":[190],"cancer.":[192],"Given":[193],"similarities":[195],"human":[199,222],"respect":[202],"biology":[205],"activation,":[208],"it":[209],"likely":[211],"STA-9090":[215],"will":[216],"demonstrate":[217],"comparable":[218],"anti-cancer":[219],"patients.":[223],"Citation":[224],"Format:":[225],"{Authors}.":[226],"{Abstract":[227],"title}":[228],"[abstract].":[229],"In:":[230],"Proceedings":[231],"102nd":[234],"Annual":[235],"Meeting":[236],"American":[239],"Association":[240],"Cancer":[242,252],"Research;":[243],"2011":[244],"Apr":[245],"2-6;":[246],"Orlando,":[247],"FL.":[248],"Philadelphia":[249],"(PA):":[250],"AACR;":[251],"Res":[253],"2011;71(8":[254],"Suppl):Abstract":[255],"nr":[256],"1282.":[257],"doi:10.1158/1538-7445.AM2011-1282":[258]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2016-06-24T00:00:00"}
