{"id":"https://openalex.org/W2090977677","doi":"https://doi.org/10.1038/nm0596-585","title":"Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction","display_name":"Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2090977677","doi":"https://doi.org/10.1038/nm0596-585","mag":"2090977677","pmid":"https://pubmed.ncbi.nlm.nih.gov/8616721"},"language":"en","primary_location":{"id":"doi:10.1038/nm0596-585","doi":"https://doi.org/10.1038/nm0596-585","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm0596-585","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103526130","display_name":"Joseph A. Cioffi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255310","display_name":"Indiana University Columbus","ror":"https://ror.org/02vnghs48","country_code":"US","type":"education","lineage":["https://openalex.org/I4405255310","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Cioffi","raw_affiliation_strings":["Progenitor, Inc., Columbus, Ohio 43212, USA","Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Progenitor, Inc., Columbus, Ohio 43212, USA","institution_ids":["https://openalex.org/I4405255310"]},{"raw_affiliation_string":"Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109098652","display_name":"Alan Shafer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan W. Shafer","raw_affiliation_strings":["Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056297932","display_name":"Thomas J. Zupancic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Zupancic","raw_affiliation_strings":["Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058702904","display_name":"Julie Smith-Gbur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Smith-Gbur","raw_affiliation_strings":["Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103419693","display_name":"Adel A. Mikhail","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adel Mikhail","raw_affiliation_strings":["Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034526583","display_name":"Doros Platika","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doros Platika","raw_affiliation_strings":["Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109051211","display_name":"H. Ralph Snodgrass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. Ralph Snodgrass","raw_affiliation_strings":["Department of Internal Medicine, Division of Bone Marrow Transplantation, Ohio State University Medical School, Columbus, Ohio, 43210, USA","Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Bone Marrow Transplantation, Ohio State University Medical School, Columbus, Ohio, 43210, USA","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]},{"raw_affiliation_string":"Progenitor, Inc., 1507 Chambers Rd, Columbus, Ohio, 43212, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109051211"],"corresponding_institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":40.2602,"has_fulltext":false,"cited_by_count":615,"citation_normalized_percentile":{"value":0.99945115,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"2","issue":"5","first_page":"585","last_page":"589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.2222999930381775,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/receptor-isoforms","display_name":"receptor isoforms","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/yolk-sac","display_name":"yolk sac","score":0.8550000190734863},{"id":"https://openalex.org/keywords/obesity-genes","display_name":"obesity-related genes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/genitalia","display_name":"genitalia","score":0.5879999995231628},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.7369999885559082},{"id":"https://openalex.org/keywords/endothelial-development","display_name":"endothelial development","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7693108320236206},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7395691871643066},{"id":"https://openalex.org/C2777043721","wikidata":"https://www.wikidata.org/wiki/Q369887","display_name":"Yolk sac","level":3,"score":0.5343661904335022},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.5182690024375916},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4891998767852783},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.48745274543762207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45585474371910095},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4303862750530243},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42124953866004944},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4132803678512573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38301795721054077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36008527874946594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3248506784439087},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2006339728832245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20043891668319702},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006066","descriptor_name":"Gonads","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nm0596-585","doi":"https://doi.org/10.1038/nm0596-585","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm0596-585","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},{"id":"pmid:8616721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8616721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W27140539","https://openalex.org/W39516543","https://openalex.org/W1510017376","https://openalex.org/W1530543461","https://openalex.org/W1902836344","https://openalex.org/W1996713062","https://openalex.org/W1998566378","https://openalex.org/W1999887945","https://openalex.org/W2005854869","https://openalex.org/W2008577129","https://openalex.org/W2016994959","https://openalex.org/W2017223857","https://openalex.org/W2025846514","https://openalex.org/W2032237595","https://openalex.org/W2050719437","https://openalex.org/W2051192888","https://openalex.org/W2055956383","https://openalex.org/W2060958975","https://openalex.org/W2070879288","https://openalex.org/W2086124769","https://openalex.org/W2089936456","https://openalex.org/W2120056767","https://openalex.org/W2132022427","https://openalex.org/W2143166206","https://openalex.org/W2149397006","https://openalex.org/W2172413152","https://openalex.org/W2179601534","https://openalex.org/W2344615469","https://openalex.org/W2413217421"],"related_works":["https://openalex.org/W2067935095","https://openalex.org/W2069038722","https://openalex.org/W1980558382","https://openalex.org/W2061979997","https://openalex.org/W1967772553","https://openalex.org/W2181595615","https://openalex.org/W2076611707","https://openalex.org/W1910514939","https://openalex.org/W2028039109","https://openalex.org/W2086423808"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}