{"id":"https://openalex.org/W2090959453","doi":"https://doi.org/10.1172/jci118194","title":"Cloning and regulation of expression of the rat kidney urea transporter (rUT2).","display_name":"Cloning and regulation of expression of the rat kidney urea transporter (rUT2).","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2090959453","doi":"https://doi.org/10.1172/jci118194","mag":"2090959453","pmid":"https://pubmed.ncbi.nlm.nih.gov/7657826","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/185781"},"language":"en","primary_location":{"id":"doi:10.1172/jci118194","doi":"https://doi.org/10.1172/jci118194","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118194","pdf_url":"http://www.jci.org/articles/view/118194/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/118194/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103060857","display_name":"Craig P. Smith","orcid":"https://orcid.org/0000-0002-4828-2700","observed_orcids":["https://orcid.org/0000-0002-4828-2700"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C P Smith","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037032483","display_name":"Wen\u2010Sen Lee","orcid":"https://orcid.org/0000-0002-7362-1815","observed_orcids":["https://orcid.org/0000-0002-7362-1815"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W S Lee","raw_affiliation_strings":["Cardiovascular Biology Laboratory , Harvard School of Public Health , Boston , MA 02115 ","Renal Division , Brig- ham and Women's Hospital , 75 Francis Street , Boston , MA 02115 ","Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","Graduate Institute of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Biology Laboratory , Harvard School of Public Health , Boston , MA 02115 ","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Renal Division , Brig- ham and Women's Hospital , 75 Francis Street , Boston , MA 02115 ","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Graduate Institute of Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103025612","display_name":"Sonia Martial","orcid":"https://orcid.org/0000-0002-6732-0936","observed_orcids":["https://orcid.org/0000-0002-6732-0936"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Martial","raw_affiliation_strings":["Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029048638","display_name":"Mark A. Knepper","orcid":"https://orcid.org/0000-0002-2276-8091","observed_orcids":["https://orcid.org/0000-0002-2276-8091"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Knepper","raw_affiliation_strings":["tRenal Division , Department of Medicine , Emory University School of Medicine , Atlanta , Georgia 30322 ; and \u00a7Laboratory of Kidney and Electrolyte Metabolism ,","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"tRenal Division , Department of Medicine , Emory University School of Medicine , Atlanta , Georgia 30322 ; and \u00a7Laboratory of Kidney and Electrolyte Metabolism ,","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G You","raw_affiliation_strings":["National Heart, Lung, and Blood Institute , National Institutes of Health , Bethesda , Maryland 20892","Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute , National Institutes of Health , Bethesda , Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014014770","display_name":"Jeff M. Sands","orcid":"https://orcid.org/0000-0001-9822-0607","observed_orcids":["https://orcid.org/0000-0001-9822-0607"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Sands","raw_affiliation_strings":["Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Hediger","raw_affiliation_strings":["Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division , Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts 02115 ;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.066,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.92843862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"96","issue":"3","first_page":"1556","last_page":"1563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urine-concentrating-mechanism","display_name":"urine concentrating mechanism","score":0.7289999723434448},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.7789999842643738},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.6949999928474426},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.5709999799728394},{"id":"https://openalex.org/keywords/hydration-status","display_name":"hydration status","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nitrogen-balance","display_name":"nitrogen balance","score":0.8080000281333923},{"id":"https://openalex.org/keywords/fluid-balance","display_name":"fluid balance","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.75}],"concepts":[{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.6624873280525208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.593727707862854},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5875144600868225},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5722017884254456},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5342838764190674},{"id":"https://openalex.org/C2778423325","wikidata":"https://www.wikidata.org/wiki/Q2268463","display_name":"Phloretin","level":2,"score":0.515689492225647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4911904036998749},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4619847238063812},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.45552027225494385},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4358450174331665},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4327634871006012},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4258264899253845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32445254921913147},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2944380044937134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26827818155288696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000096982","descriptor_name":"Urea Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004231","descriptor_name":"Diuresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008961","descriptor_name":"Models, Structural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci118194","doi":"https://doi.org/10.1172/jci118194","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118194","pdf_url":"http://www.jci.org/articles/view/118194/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:185781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/185781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:7657826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7657826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comparative Study"},{"id":"pmh:oai:HAL:hal-02376421v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02376421","pdf_url":"https://hal.science/hal-02376421v1/file/Smith%20-%201995%20-%20Cloning%20and%20regulation%20of%20rUT2.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation, 1995, ⟨10.1172/JCI118194⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci118194","doi":"https://doi.org/10.1172/jci118194","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118194","pdf_url":"http://www.jci.org/articles/view/118194/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3528507391","display_name":null,"funder_award_id":"R01-DK707844","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7805235926","display_name":"REGULATION OF RAT RENAL INNER MEDULLARY FUNCTION","funder_award_id":"R29DK041707","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G835508346","display_name":"REGULATION OF URINE CONCENTRATING ABILITY IN RAT KIDNEY","funder_award_id":"R01DK045688","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8985077591","display_name":"Regulation of Renal Inner Medullary Function","funder_award_id":"R01DK041707","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090959453.pdf","grobid_xml":"https://content.openalex.org/works/W2090959453.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W218175079","https://openalex.org/W1485456553","https://openalex.org/W1541548986","https://openalex.org/W1580090335","https://openalex.org/W1618643845","https://openalex.org/W1848248203","https://openalex.org/W1991425261","https://openalex.org/W2013005355","https://openalex.org/W2025460399","https://openalex.org/W2039841405","https://openalex.org/W2041099611","https://openalex.org/W2066441977","https://openalex.org/W2071277783","https://openalex.org/W2076216028","https://openalex.org/W2082414348","https://openalex.org/W2087534198","https://openalex.org/W2093407677","https://openalex.org/W2121810210","https://openalex.org/W2129508153","https://openalex.org/W2135152819","https://openalex.org/W2148984043","https://openalex.org/W2170596122","https://openalex.org/W2187992481","https://openalex.org/W2223937487","https://openalex.org/W2278221945","https://openalex.org/W2279354174","https://openalex.org/W2313309482","https://openalex.org/W2315892236","https://openalex.org/W2323540000","https://openalex.org/W2330760529","https://openalex.org/W2397002128","https://openalex.org/W2402124262","https://openalex.org/W2402716553","https://openalex.org/W2408221665","https://openalex.org/W2415942952","https://openalex.org/W2417622984","https://openalex.org/W2419537200","https://openalex.org/W2419650311","https://openalex.org/W4242746409"],"related_works":["https://openalex.org/W2013187640","https://openalex.org/W2302385627","https://openalex.org/W2120123261","https://openalex.org/W2025460399","https://openalex.org/W1975794640","https://openalex.org/W2441082476","https://openalex.org/W2012818550","https://openalex.org/W1998098091","https://openalex.org/W2080823491","https://openalex.org/W1953206860"],"abstract_inverted_index":{"In":[0],"mammals,":[1],"urea":[2,45,61,124,242],"is":[3,25],"the":[4,16,22,28,31,50,55,78,119,174,183,187,190,198,202,208,212,237,240,256],"predominant":[5],"end-product":[6],"of":[7,30,44,58,70,82,148,155,186,201,211,239,255],"nitrogen":[8,225],"metabolism":[9],"and":[10,47,67,95,115,139,158,168,224,245,260],"plays":[11],"a":[12,74,247],"central":[13],"role":[14],"in":[15,21,49,169,182,197],"urinary-concentrating":[17],"mechanism.":[18],"Urea":[19],"accumulation":[20,48],"renal":[23,51,241],"medulla":[24,52],"critical":[26],"to":[27,33,36,112,118,180,195,221,227,251],"ability":[29],"kidney":[32,150],"concentrate":[34],"urine":[35],"an":[37],"osmolality":[38],"greater":[39],"than":[40],"systemic":[41],"plasma.":[42],"Regulation":[43],"excretion":[46],"depends":[53],"on":[54,249],"functional":[56],"state":[57,200],"specialized":[59],"phloretin-sensitive":[60],"transporters.":[62],"To":[63],"study":[64],"these":[65],"transporters":[66],"their":[68],"regulation":[69,238],"expression":[71,209],"we":[72],"isolated":[73],"cDNA":[75],"which":[76,161,250],"encodes":[77],"rat":[79,149],"homologue":[80],"(rUT2)":[81],"rabbit":[83,113],"UT2":[84,105,114,244],"(You,":[85],"G.,":[86],"C.P.":[87],"Smith,":[88],"Y.":[89],"Kanai,":[90],"W.-S.":[91],"Lee,":[92],"M.":[93],"Stelzner,":[94],"M.A.":[96,133],"Hediger,":[97,134],"et":[98],"al.":[99],"Nature":[100],"(Lond.).":[101],"1993.":[102],"365:844-847).":[103],"Rat":[104],"has":[106],"88%":[107],"amino":[108],"acid":[109],"sequence":[110],"identity":[111,117],"64%":[116],"recently":[120],"cloned":[121],"human":[122],"erythrocyte":[123],"transporter,":[125],"HUT11":[126],"(Olives,":[127],"B.,":[128],"P.":[129,131,140],"Neav,":[130],"Bailly,":[132],"G.":[135],"Rousselet,":[136],"J.P.":[137],"Cartron,":[138],"Ripoch":[141],"J.":[142],"Biol.":[143],"Chem.":[144],"1994.":[145],"269:31649-31652).":[146],"Analysis":[147],"mRNA":[151],"revealed":[152],"two":[153,213],"transcripts":[154,215],"size":[156],"2.9":[157],"4.0":[159],"kb":[160],"had":[162],"spatially":[163],"distinct":[164],"distributions.":[165],"Northern":[166],"analysis":[167],"situ":[170],"hybridization":[171],"showed":[172],"that":[173,207],"4.0-kb":[175],"transcript":[176,192],"was":[177,193],"primarily":[178],"responsive":[179,194],"changes":[181,196],"protein":[184],"content":[185],"diet":[188],"whereas":[189],"2.9-kb":[191],"hydration":[199],"animal.":[203],"These":[204],"studies":[205],"reveal":[206],"levels":[210],"rUT2":[214],"are":[216],"modulated":[217],"by":[218],"different":[219],"pathways":[220],"allow":[222],"fluid":[223],"balance":[226],"be":[228],"regulated":[229],"independently.":[230],"Our":[231],"data":[232],"provide":[233,246],"important":[234],"insights":[235],"into":[236],"transporter":[243],"basis":[248],"refine":[252],"our":[253],"understanding":[254],"urinary":[257],"concentrating":[258],"mechanism":[259],"its":[261],"regulation.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}