{"id":"https://openalex.org/W2090946136","doi":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","title":"Hydrolysis of suxamethonium by different types of plasma","display_name":"Hydrolysis of suxamethonium by different types of plasma","publication_year":1969,"publication_date":"1969-09-01","ids":{"openalex":"https://openalex.org/W2090946136","doi":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","mag":"2090946136","pmid":"https://pubmed.ncbi.nlm.nih.gov/4981001","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1703787"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1969.tb09543.x","doi":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1969.tb09543.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1969.tb09543.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006410314","display_name":"Franz Hobbiger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. HOBBIGER","raw_affiliation_strings":["Department of Pharmacology, The Middlesex Hospital Medical School, London, W1P 5FD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Middlesex Hospital Medical School, London, W1P 5FD","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113457504","display_name":"Anthony W. Peck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. W. PECK","raw_affiliation_strings":["Department of Pharmacology, The Middlesex Hospital Medical School, London, W1P 5FD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Middlesex Hospital Medical School, London, W1P 5FD","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":4.3517,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.93430034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"1","first_page":"258","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/succinylcholine","display_name":"succinylcholine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cholinesterase","display_name":"cholinesterase","score":0.7480000257492065},{"id":"https://openalex.org/keywords/plasma-hydrolysis","display_name":"plasma hydrolysis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/butyrylcholine","display_name":"butyrylcholine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/benzoylcholine","display_name":"benzoylcholine","score":0.996999979019165},{"id":"https://openalex.org/keywords/atypical-cholinesterase","display_name":"atypical cholinesterase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/decamethonium","display_name":"decamethonium","score":0.722000002861023},{"id":"https://openalex.org/keywords/dibucaine","display_name":"dibucaine","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sodium-fluoride","display_name":"sodium fluoride","score":0.6629999876022339},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.47099998593330383},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.8698351383209229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7897020578384399},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.676869809627533},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.6182675957679749},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.46873268485069275},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45673537254333496},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.43083593249320984},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4196047782897949},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.265562504529953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10360398888587952}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001001","descriptor_name":"Anura","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003650","descriptor_name":"Decamethonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003992","descriptor_name":"Dibucaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005459","descriptor_name":"Fluorides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013390","descriptor_name":"Succinylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1969.tb09543.x","doi":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1969.tb09543.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1703787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1703787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:4981001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4981001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1969.tb09543.x","doi":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1969.tb09543.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1969.tb09543.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090946136.pdf","grobid_xml":"https://content.openalex.org/works/W2090946136.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W26210540","https://openalex.org/W78013147","https://openalex.org/W626485227","https://openalex.org/W1958488325","https://openalex.org/W1974932868","https://openalex.org/W1975390210","https://openalex.org/W1976747270","https://openalex.org/W1978647299","https://openalex.org/W1986928414","https://openalex.org/W1987385392","https://openalex.org/W1997895434","https://openalex.org/W2000030735","https://openalex.org/W2008729439","https://openalex.org/W2040501322","https://openalex.org/W2042031895","https://openalex.org/W2052786260","https://openalex.org/W2054115494","https://openalex.org/W2059855509","https://openalex.org/W2065032669","https://openalex.org/W2066006937","https://openalex.org/W2066851444","https://openalex.org/W2073034293","https://openalex.org/W2074947465","https://openalex.org/W2078260002","https://openalex.org/W2261825334","https://openalex.org/W2262814062","https://openalex.org/W2399505281","https://openalex.org/W2415618374","https://openalex.org/W4248098710","https://openalex.org/W4406984668"],"related_works":["https://openalex.org/W1995214167","https://openalex.org/W2083008644","https://openalex.org/W2426147267","https://openalex.org/W1907158351","https://openalex.org/W2415038278","https://openalex.org/W2106831005","https://openalex.org/W2399505281","https://openalex.org/W2054159774","https://openalex.org/W1984314839","https://openalex.org/W2054115494"],"abstract_inverted_index":{"1.":[0],"A":[1],"method,":[2],"based":[3],"on":[4,150],"the":[5,8,19,82,116,135,141,151,156,163,166,189,192,197,200,204,234,237,241,261,292],"use":[6],"of":[7,21,27,29,51,57,59,64,84,118,132,155,158,168,170,178,186,191,199,203,229,233,264,291,294,303,305,310],"isolated":[9],"frog":[10],"rectus":[11],"abdominis":[12],"preparation,":[13],"is":[14,100,269,296],"described":[15],"for":[16,124,129,138,194,236,282],"studying":[17],"quantitatively":[18],"hydrolysis":[20,28,58,157,169,293,304],"suxamethonium":[22,60,77,139,215,249,306],"at":[23],"low":[24],"concentrations.2.":[25],"Rates":[26],"butyrylcholine,":[30],"10":[31],"mM,":[32,35,39,173],"benzoylcholine,":[33],"0.05":[34],"and":[36,45,73,87,89,112,148,196],"suxamethonium,":[37,171],"0.025":[38,172],"by":[40,61,115,153,286,307],"plasma":[41,47,65,69,75,83,91,133,179,210,221,245,255,268],"from":[42],"different":[43,62,130,176,308],"species":[44],"human":[46,90,209,220,254,276],"with":[48,70,92,162,175,211,222,256],"genetic":[49],"variants":[50],"cholinesterase":[52,72,195,213,224,258,265],"were":[53],"measured.3.":[54],"The":[55,121,278],"rates":[56,167,302],"types":[63,131,177,309],"vary":[66,144,180],"widely.":[67],"Human":[68],"usual":[71,223,257],"monkey":[74,283],"hydrolyse":[76,248],"more":[78,271],"speedily":[79],"than":[80,218,252,273],"do":[81],"cats,":[85],"dogs":[86],"rats,":[88],"either":[93],"atypical":[94,212],"or":[95,226,288],"fluoride":[96,290],"resistant":[97],"cholinesterase.":[98,205],"This":[99],"only":[101],"to":[102,107,247,301],"a":[103,184,298],"small":[104],"extent":[105],"attributable":[106],"differences":[108,230],"in":[109,140,231,266,275],"enzyme":[110],"concentration":[111],"not":[113,297],"explained":[114],"presence":[117],"an":[119],"inhibitor.4.":[120],"K(m)":[122],"values":[123,137],"butyrylcholine":[125,159],"are":[126,160,183],"very":[127],"similar":[128],"but":[134],"K(I)":[136],"system":[142],"plasma-butyrylcholine-suxamethonium":[143],"greatly.5.":[145],"These":[146],"results":[147],"observations":[149],"inhibition":[152],"decamethonium":[154],"consistent":[161],"interpretation":[164],"that":[165,208,274],"obtained":[174],"because":[181,228,260],"they":[182],"function":[185],"two":[187,238],"variables,":[188],"affinity":[190,232],"ester":[193,235],"stability":[198],"monosuccinyl":[201,262],"derivative":[202,263],"It":[206],"seems":[207],"hydrolyses":[214],"much":[216,250,270],"slower":[217,251],"does":[219,253],"mainly":[225,259],"solely":[227],"enzymes.":[239],"On":[240],"other":[242],"hand,":[243],"cat":[244,267],"appears":[246],"stable":[272],"plasma.":[277,311],"reverse":[279],"might":[280],"apply":[281],"plasma.6.":[284],"Inhibition":[285],"dibucaine":[287],"sodium":[289],"benzoylcholine":[295],"general":[299],"guide":[300]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
