{"id":"https://openalex.org/W2090940253","doi":"https://doi.org/10.1159/000223108","title":"Immunsuppressivit\u00e4t parenteraler Fettemulsionen bei definierter Immunstimulation","display_name":"Immunsuppressivit\u00e4t parenteraler Fettemulsionen bei definierter Immunstimulation","publication_year":2009,"publication_date":"2009-05-27","ids":{"openalex":"https://openalex.org/W2090940253","doi":"https://doi.org/10.1159/000223108","mag":"2090940253","pmid":"https://pubmed.ncbi.nlm.nih.gov/7787404"},"language":"de","primary_location":{"id":"doi:10.1159/000223108","doi":"https://doi.org/10.1159/000223108","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000223108","pdf_url":null,"source":{"id":"https://openalex.org/S4210192054","display_name":"Infusionstherapie und Transfusionsmedizin / Infusion Therapy and Transfusion Medicine","issn_l":"1019-8466","issn":["1019-8466","1423-0089","1424-5485","1424-5493"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["oarl","poland-70"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infusionstherapie und Transfusionsmedizin / Infusion Therapy and Transfusion Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H. Grimm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"H. Grimm","raw_affiliation_strings":["Abteilung f\u00fcr Allgemein- und Thoraxchirurgie, Universit\u00e4t Gie\u03b2en","Karolinska-Institut, Abteilung f\u00fcr Transplan-tationschirurgie, Stockholm, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Allgemein- und Thoraxchirurgie, Universit\u00e4t Gie\u03b2en","institution_ids":["https://openalex.org/I200763008"]},{"raw_affiliation_string":"Karolinska-Institut, Abteilung f\u00fcr Transplan-tationschirurgie, Stockholm, Schweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012287375","display_name":"Annika Tibell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Tibell","raw_affiliation_strings":["Karolinska-Institut, Abteilung f\u00fcr Transplan-tationschirurgie, Stockholm, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska-Institut, Abteilung f\u00fcr Transplan-tationschirurgie, Stockholm, Schweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111987935","display_name":"B. Norrlind","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Norrlind","raw_affiliation_strings":["Institut f\u00fcr Ern\u00e4hrungsforschung G4, Kabi Pharmacia, Stockholm, Schweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Ern\u00e4hrungsforschung G4, Kabi Pharmacia, Stockholm, Schweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109557916","display_name":"J. Schott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Schott","raw_affiliation_strings":["Abteilung f\u00fcr Allgemein- und Thoraxchirurgie, Universit\u00e4t Gie\u03b2en"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Allgemein- und Thoraxchirurgie, Universit\u00e4t Gie\u03b2en","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108400567","display_name":"Rainer Maria Bohle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R.M. Bohle","raw_affiliation_strings":["Institut f\u00fcr Pathologie, Universit\u00e4t Gie\u03b2en"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pathologie, Universit\u00e4t Gie\u03b2en","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000865380","display_name":"Ch. Papavassilis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ch. Papavassilis","raw_affiliation_strings":["Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. F\u00fchrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. F\u00fchrer","raw_affiliation_strings":["Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109973068","display_name":"K. Mayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Mayer","raw_affiliation_strings":["Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084935661","display_name":"Friedrich Grimminger","orcid":"https://orcid.org/0000-0001-8725-6276","observed_orcids":["https://orcid.org/0000-0001-8725-6276"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Grimminger","raw_affiliation_strings":["Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik I des Zentrums f\u00fcr Innere Medizin, Universit\u00e4t Gie\u03b2en","institution_ids":["https://openalex.org/I200763008"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.24354614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"2","first_page":"110","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.4661000072956085,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.3840000033378601,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9610000252723694},{"id":"https://openalex.org/keywords/n-6-n-3-ratio","display_name":"n-6/n-3 ratio","score":0.9760000109672546},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.7009999752044678},{"id":"https://openalex.org/keywords/safflower-oil","display_name":"safflower oil","score":0.8479999899864197},{"id":"https://openalex.org/keywords/fish-oil","display_name":"fish oil","score":1.0},{"id":"https://openalex.org/keywords/soybean-oil","display_name":"soybean oil","score":1.0},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9079999923706055},{"id":"https://openalex.org/keywords/leukotriene-b5","display_name":"leukotriene B5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9390000104904175},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mononuclear-cells","display_name":"mononuclear cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5285552740097046},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5180040001869202},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3406762480735779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2185954451560974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15866270661354065}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005217","descriptor_name":"Fat Emulsions, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010289","descriptor_name":"Parenteral Nutrition, Total","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016042","descriptor_name":"Transplantation, Heterotopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000223108","doi":"https://doi.org/10.1159/000223108","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000223108","pdf_url":null,"source":{"id":"https://openalex.org/S4210192054","display_name":"Infusionstherapie und Transfusionsmedizin / Infusion Therapy and Transfusion Medicine","issn_l":"1019-8466","issn":["1019-8466","1423-0089","1424-5485","1424-5493"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["oarl","poland-70"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infusionstherapie und Transfusionsmedizin / Infusion Therapy and Transfusion Medicine","raw_type":"journal-article"},{"id":"pmid:7787404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7787404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infusionstherapie und Transfusionsmedizin","raw_type":"Comparative Study"},{"id":"mag:2395273497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7787404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W459156541","https://openalex.org/W2395273497","https://openalex.org/W2345581797","https://openalex.org/W2462012967","https://openalex.org/W2027181231","https://openalex.org/W2167199109","https://openalex.org/W2048534789","https://openalex.org/W6963506308","https://openalex.org/W1983736395","https://openalex.org/W2083464847"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,152],"the":[2,45,147,153,157,163,175,194,206,213,229],"heterotopic":[3],"rat":[4],"heart":[5],"allotransplant":[6],"model":[7],"we":[8],"have":[9],"previously":[10],"shown":[11],"that":[12],"intravenous":[13],"fat":[14,219,280],"emulsions":[15,92,220,281],"are":[16,290],"to":[17,49,56,81,172,184,205],"a":[18,76,101,222,251,262,283],"various":[19],"extent":[20],"immunosuppressive":[21,248,275],"or":[22],"immunoneutral,":[23],"dependent":[24],"on":[25],"their":[26],"n-3/n-6":[27,230,265,284],"fatty":[28,231,238,244,266,285],"acid":[29,232,245,267,286],"ratio.":[30,233],"Safflower":[31],"oil":[32,38,42,99,108,196,215,260,271],"(n-3:":[33],"n-6":[34,235],"=":[35,121],"1:370),":[36],"fish":[37,96,107,195,214],"(7.6:1)":[39],"and":[40,52,63,85,100,106,130,134,137,174,236,254,279],"soybean":[41,98],"(1:6.5)":[43],"prolonged":[44],"transplant":[46],"survival":[47,80,162],"time":[48],"13.3,":[50],"12.3":[51],"10.4":[53],"days":[54,58,65],"compared":[55],"6.7":[57],"(oil":[59,109],"control":[60,67,110],"group;":[61],"1.2.1)":[62],"7.8":[64],"(saline":[66],"group)":[68,111,124],"(p":[69],"<":[70],"0.01),":[71],"respectively.":[72],"This":[73],"study":[74],"presents":[75],"correlation":[77],"of":[78,93,104,128,140,160,165,228,256,288],"graft":[79,161],"immunohistological,":[82],"cell":[83,179],"biological":[84],"biochemical":[86],"parameters.":[87],"MATERIALS":[88],"AND":[89],"METHODS:":[90],"20%":[91],"safflower":[94,105,270,277],"oil,":[95,97,278],"1:1":[102],"mixture":[103],"were":[112,144,191],"continuously":[113],"infused":[114],"(9":[115],"g":[116],"fat/kg":[117],"body":[118],"weight/day;":[119],"n":[120],"10":[122],"each":[123],"after":[125],"transplantation.":[126],"Subpopulations":[127],"infiltrating":[129,166],"circulating":[131,141,188],"immunocompetent":[132,257],"cells":[133,143,167,190],"leukotriene":[135,209],"B4":[136,199],"B5":[138,210],"release":[139,181],"mononuclear":[142,178],"analyzed":[145],"(on":[146],"4th":[148],"postoperative":[149],"day).":[150],"RESULTS:":[151],"2":[154],"groups":[155,204],"with":[156,261,282],"highest":[158],"prolongation":[159],"number":[164],"was":[168,200],"reduced":[169,192],"by":[170,182,250],"up":[171,183],"40%":[173],"peripheral":[176],"blood":[177],"interleukin-6":[180],"45%.":[185],"Beyond":[186],"that,":[187],"T":[189],"in":[193,202,212,226],"group.":[197,216],"Leukotriene":[198],"released":[201],"all":[203],"same":[207],"extent,":[208],"exclusively":[211],"CONCLUSIONS:":[217],"Intravenous":[218],"show":[221],"varying":[223],"immunomodulatory":[224],"effect":[225],"dependence":[227],"Both":[234],"n-3":[237],"acids,":[239],"if":[240],"applied":[241],"as":[242],"main":[243],"source,":[246],"exert":[247],"effects":[249],"diminished":[252],"infiltration":[253],"mobilisation":[255],"cells.":[258],"Soybean":[259],"more":[263],"balanced":[264],"ratio":[268,287],"than":[269,276],"is":[272],"significantly":[273],"less":[274],"1:2":[289],"immunologically":[291],"neutral.":[292]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}