{"id":"https://openalex.org/W2090937429","doi":"https://doi.org/10.1016/j.mce.2014.01.010","title":"Astrocyte-derived growth factors and estrogen neuroprotection: Role of transforming growth factor-\u03b1 in estrogen-induced upregulation of glutamate transporters in astrocytes","display_name":"Astrocyte-derived growth factors and estrogen neuroprotection: Role of transforming growth factor-\u03b1 in estrogen-induced upregulation of glutamate transporters in astrocytes","publication_year":2014,"publication_date":"2014-01-18","ids":{"openalex":"https://openalex.org/W2090937429","doi":"https://doi.org/10.1016/j.mce.2014.01.010","mag":"2090937429","pmid":"https://pubmed.ncbi.nlm.nih.gov/24447465","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040305"},"language":"en","primary_location":{"id":"doi:10.1016/j.mce.2014.01.010","doi":"https://doi.org/10.1016/j.mce.2014.01.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mce.2014.01.010","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040305","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089738260","display_name":"Pratap Karki","orcid":"https://orcid.org/0000-0002-3087-5516","observed_orcids":["https://orcid.org/0000-0002-3087-5516"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratap Karki","raw_affiliation_strings":["Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037510492","display_name":"Keisha Smith","orcid":"https://orcid.org/0000-0001-7655-7997","observed_orcids":["https://orcid.org/0000-0001-7655-7997"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keisha Smith","raw_affiliation_strings":["Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019892029","display_name":"James Johnson","orcid":"https://orcid.org/0000-0003-2556-7778","observed_orcids":["https://orcid.org/0000-0003-2556-7778"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Johnson","raw_affiliation_strings":["Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100622533","display_name":"Eun-Sook Lee","orcid":"https://orcid.org/0000-0001-7047-5288","observed_orcids":["https://orcid.org/0000-0001-7047-5288"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eunsook Lee","raw_affiliation_strings":["Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA. Electronic address: elee@mmc.edu","Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA. Electronic address: elee@mmc.edu","institution_ids":["https://openalex.org/I118073183"]},{"raw_affiliation_string":"Department of Physiology, School of Medicine, Meharry Medical College, Nashville, TN, USA","institution_ids":["https://openalex.org/I118073183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100622533"],"corresponding_institution_ids":["https://openalex.org/I118073183"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":0.7981,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.6011236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"389","issue":"1-2","first_page":"58","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.972000002861023},{"id":"https://openalex.org/keywords/estrogen-neuroprotection","display_name":"estrogen neuroprotection","score":0.8899999856948853},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.953000009059906},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.859000027179718},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9138705134391785},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.785612940788269},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.771681547164917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5324208736419678},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5180054306983948},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48287084698677063},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4570782780647278},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.41417810320854187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4140767455101013},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.412320077419281},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3221660256385803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13791018724441528},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11822262406349182},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11044362187385559},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.mce.2014.01.010","doi":"https://doi.org/10.1016/j.mce.2014.01.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mce.2014.01.010","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},{"id":"pmid:24447465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24447465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3404910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040305","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4040305","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040305","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cell Endocrinol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3404910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040305","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2622160959","display_name":"Estrogen-neuroprotection due to astroglial Glu transporters occurs via TFG-a/bl","funder_award_id":"SC1GM089630","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4415224761","display_name":"The Meharry RISE initiative","funder_award_id":"R25GM059994","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G537290280","display_name":null,"funder_award_id":"SC1 089630","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W38866710","https://openalex.org/W88146268","https://openalex.org/W1488284274","https://openalex.org/W1494125886","https://openalex.org/W1550159293","https://openalex.org/W1606732951","https://openalex.org/W1661647511","https://openalex.org/W1726588509","https://openalex.org/W1751768857","https://openalex.org/W1768963439","https://openalex.org/W1824170643","https://openalex.org/W1928820616","https://openalex.org/W1948716141","https://openalex.org/W1956013732","https://openalex.org/W1963092557","https://openalex.org/W1966698297","https://openalex.org/W1967149184","https://openalex.org/W1968981889","https://openalex.org/W1968998907","https://openalex.org/W1974105812","https://openalex.org/W1976265701","https://openalex.org/W1977529472","https://openalex.org/W1978361606","https://openalex.org/W1979536838","https://openalex.org/W1980147601","https://openalex.org/W1980276379","https://openalex.org/W1981072854","https://openalex.org/W1981305733","https://openalex.org/W1981912305","https://openalex.org/W1986224339","https://openalex.org/W1991966343","https://openalex.org/W1993693608","https://openalex.org/W1996589674","https://openalex.org/W1998695362","https://openalex.org/W2002327891","https://openalex.org/W2002879969","https://openalex.org/W2003127863","https://openalex.org/W2004065307","https://openalex.org/W2004469687","https://openalex.org/W2005547107","https://openalex.org/W2006173437","https://openalex.org/W2007980908","https://openalex.org/W2008820856","https://openalex.org/W2009139369","https://openalex.org/W2019052857","https://openalex.org/W2021742640","https://openalex.org/W2024344832","https://openalex.org/W2025624761","https://openalex.org/W2025849462","https://openalex.org/W2025960931","https://openalex.org/W2025972963","https://openalex.org/W2028338900","https://openalex.org/W2029937779","https://openalex.org/W2030950206","https://openalex.org/W2037584349","https://openalex.org/W2043348076","https://openalex.org/W2045096990","https://openalex.org/W2045244003","https://openalex.org/W2051493946","https://openalex.org/W2052780535","https://openalex.org/W2055129010","https://openalex.org/W2059172386","https://openalex.org/W2060089716","https://openalex.org/W2060838923","https://openalex.org/W2063165012","https://openalex.org/W2063315017","https://openalex.org/W2063616597","https://openalex.org/W2065804639","https://openalex.org/W2065938547","https://openalex.org/W2066220221","https://openalex.org/W2067996406","https://openalex.org/W2069498125","https://openalex.org/W2070621825","https://openalex.org/W2071491662","https://openalex.org/W2073672013","https://openalex.org/W2075564085","https://openalex.org/W2077437805","https://openalex.org/W2080245596","https://openalex.org/W2085426503","https://openalex.org/W2093160885","https://openalex.org/W2094046759","https://openalex.org/W2095698264","https://openalex.org/W2100775280","https://openalex.org/W2100775283","https://openalex.org/W2107020136","https://openalex.org/W2107119262","https://openalex.org/W2108046041","https://openalex.org/W2119504151","https://openalex.org/W2119588378","https://openalex.org/W2121513807","https://openalex.org/W2124549591","https://openalex.org/W2128640727","https://openalex.org/W2130617495","https://openalex.org/W2130695898","https://openalex.org/W2131444429","https://openalex.org/W2134627266","https://openalex.org/W2149497936","https://openalex.org/W2156965301","https://openalex.org/W2167093282","https://openalex.org/W2169886803","https://openalex.org/W2312258226","https://openalex.org/W2948665150","https://openalex.org/W4211081379","https://openalex.org/W4214829914"],"related_works":["https://openalex.org/W2061188673","https://openalex.org/W2052780535","https://openalex.org/W1981912305","https://openalex.org/W2121513807","https://openalex.org/W1997221862","https://openalex.org/W2070621825","https://openalex.org/W1913069989","https://openalex.org/W1967149184","https://openalex.org/W2088763858","https://openalex.org/W1991966343"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
