{"id":"https://openalex.org/W2090907783","doi":"https://doi.org/10.1089/jop.1990.6.43","title":"L-Buthionine Sulfoximine-Induced Loss of Glutathione Does Not Elicit PGH Synthase Inactivation in Cultured Bovine Lens Epithelial Cells","display_name":"L-Buthionine Sulfoximine-Induced Loss of Glutathione Does Not Elicit PGH Synthase Inactivation in Cultured Bovine Lens Epithelial Cells","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2090907783","doi":"https://doi.org/10.1089/jop.1990.6.43","mag":"2090907783","pmid":"https://pubmed.ncbi.nlm.nih.gov/2113938"},"language":"en","primary_location":{"id":"doi:10.1089/jop.1990.6.43","doi":"https://doi.org/10.1089/jop.1990.6.43","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jop.1990.6.43","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108229402","display_name":"Patrick R. Cammarata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PATRICK R. CAMMARATA","raw_affiliation_strings":["Department of Anatomy, Texas College of Osteopathic Medicine, Fort Worth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Texas College of Osteopathic Medicine, Fort Worth","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110155612","display_name":"Thomas Yorio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"THOMAS YORIO","raw_affiliation_strings":["","Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3467,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62719477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":"43","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.21799999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-buthionine-sulfoximine","display_name":"L-buthionine sulfoximine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9470000267028809},{"id":"https://openalex.org/keywords/prostaglandin-h-synthase","display_name":"prostaglandin H synthase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.7960000038146973},{"id":"https://openalex.org/keywords/galactitol","display_name":"galactitol","score":0.902999997138977},{"id":"https://openalex.org/keywords/polyol-accumulation","display_name":"polyol accumulation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hypergalactosemia","display_name":"hypergalactosemia","score":0.8460000157356262},{"id":"https://openalex.org/keywords/prostaglandin-synthesis","display_name":"prostaglandin synthesis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/autoxidation","display_name":"autoxidation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.49000000953674316},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.5180000066757202},{"id":"https://openalex.org/keywords/lens-metabolism","display_name":"lens metabolism","score":0.328000009059906},{"id":"https://openalex.org/keywords/bovine-lens","display_name":"bovine lens","score":0.41999998688697815},{"id":"https://openalex.org/keywords/galactosemia","display_name":"galactosemia","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2777476445","wikidata":"https://www.wikidata.org/wiki/Q5002519","display_name":"Buthionine sulfoximine","level":4,"score":0.6797641515731812},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5967487096786499},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.5489925146102905},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.528178334236145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44916045665740967},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4438033401966095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4351139962673187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38887229561805725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33871468901634216},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30493539571762085},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007903","descriptor_name":"Lens Capsule, Crystalline","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007903","descriptor_name":"Lens Capsule, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008717","descriptor_name":"Methionine Sulfoximine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008717","descriptor_name":"Methionine Sulfoximine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019328","descriptor_name":"Buthionine Sulfoximine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/jop.1990.6.43","doi":"https://doi.org/10.1089/jop.1990.6.43","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jop.1990.6.43","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:2113938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2113938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ocular pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2015850083","https://openalex.org/W2120465860","https://openalex.org/W2134397585","https://openalex.org/W2158150851","https://openalex.org/W2165191737","https://openalex.org/W2167285587","https://openalex.org/W2417082521"],"related_works":["https://openalex.org/W2167285587","https://openalex.org/W2030581866","https://openalex.org/W1971896747","https://openalex.org/W2069437675","https://openalex.org/W2011381119","https://openalex.org/W2071153095","https://openalex.org/W2417082521","https://openalex.org/W2422391587","https://openalex.org/W1569244310","https://openalex.org/W2104450421"],"abstract_inverted_index":{"Previous":[0],"studies":[1,303],"from":[2],"this":[3],"laboratory":[4],"have":[5],"indicated":[6],"that":[7,61,138,258,295,305,321],"exposure":[8,64,166,229],"of":[9,38,65,72,98,114,129,171,200,228,264,274,308,330,335],"cultured":[10],"bovine":[11],"lens":[12,325],"epithelial":[13],"cells":[14,133,161,262],"(BLECs)":[15],"to":[16,67,83,104,109,124,134,186,230,240,257,276,294],"minimal":[17],"essential":[18],"medium":[19],"(MEM)":[20],"containing":[21],"40":[22],"mM":[23],"galactose":[24],"(Gal)":[25],"for":[26,194],"as":[27,31,42,76],"short":[28],"a":[29,36,45,86,135,163,312,322,333],"duration":[30],"20":[32,164,195,226],"h":[33,165,227],"results":[34],"in":[35,47,122,131,141,159,175,178,189,208,217,223,246,252,268,299,314,324],"reduction":[37,313,334],"microsomal":[39],"prostaglandin":[40],"biosynthesis":[41],"demonstrated":[43],"by":[44],"decrease":[46],"PGH":[48,99,249,315,336],"synthase":[49,100,250,316,337],"activity":[50,97,251,292,317],"(Invest.":[51],"Ophthalmol.":[52],"Vis.":[53],"Sci.":[54],"29:1452-1460,":[55],"1988).":[56],"The":[57,112,152,197],"present":[58],"study":[59],"shows":[60],"upon":[62],"brief":[63],"BLECs":[66,107,176,187,224,254,298],"Gal,":[68],"the":[69,96,126,220,265,272,282,290,306],"cellular":[70,198,309],"content":[71,94,154,199,222],"glutathione":[73,115],"(GSH)":[74],"decreases":[75],"galactitol":[77,148,153,172],"increases.":[78],"Studies":[79],"were":[80],"therefore":[81],"undertaken":[82],"establish":[84],"whether":[85],"positive":[87],"correlation":[88],"existed":[89],"between":[90],"polyol":[91],"accumulation,":[92],"GSH":[93,130,201,221,269,284,310,327],"and":[95,211,311],"(an":[101],"enzyme":[102,291],"known":[103],"auto-oxidize)":[105],"utilizing":[106],"exposed":[108],"hypergalactosemic":[110],"conditions.":[111],"inhibitor":[113],"biosynthesis,":[116],"L-buthionine":[117],"sulfoximine":[118],"(L-BSO)":[119],"was":[120,155,173,184,202,232,255],"used":[121],"order":[123],"lower":[125],"intracellular":[127,283],"pool":[128],"MEM-incubated":[132,261],"level":[136,170],"below":[137],"routinely":[139],"observed":[140,174,259,296],"Gal-incubated":[142,160,277],"cells,":[143,278],"under":[144],"conditions":[145],"whereby":[146],"no":[147,168],"accumulation":[149],"had":[150],"occurred.":[151],"92":[156],"nmol/\u03bcg":[157],"PO4":[158,207,216,237,245],"after":[162,225],"period;":[167],"detectable":[169],"maintained":[177,188],"galactose-free":[179],"MEM.":[180],"L-(BSO)":[181],"(1":[182],"mM)":[183],"co-administered":[185],"either":[190],"MEM":[191,209],"or":[192],"Gal":[193,231,300],"h.":[196],"1.70":[203],"\u00b1.02":[204,213],"\u03bcg":[205,214,235,243],"GSH/\u03bcg":[206,215,236,244],"alone":[210],"0.540":[212],"MEM+BSO.":[218],"Furthermore,":[219],"0.960":[233],"\u00b1.01":[234,242],"but":[238],"decreased":[239],"0.110":[241],"Gal+BSO.":[247],"However,":[248],"MEM+BSO-treated":[253],"equivalent":[256],"with":[260,297],"regardless":[263],"significant":[266],"difference":[267],"content.":[270],"Likewise,":[271],"addition":[273],"BSO":[275],"while":[279],"substantially":[280],"lowering":[281],"content,":[285],"did":[286],"not":[287,329],"further":[288],"diminish":[289],"compared":[293],"alone.":[301],"These":[302],"demonstrate":[304],"depletion":[307,323],"are":[318],"uncoupled,":[319],"such":[320],"cell":[326],"does":[328],"itself":[331],"elicit":[332],"activity.":[338]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
