{"id":"https://openalex.org/W2090899216","doi":"https://doi.org/10.1158/1535-7163.targ-09-c180","title":"Abstract C180: A novel bispecific platform for potent redirected killing of B-cell lymphoma","display_name":"Abstract C180: A novel bispecific platform for potent redirected killing of B-cell lymphoma","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2090899216","doi":"https://doi.org/10.1158/1535-7163.targ-09-c180","mag":"2090899216"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-09-c180","doi":"https://doi.org/10.1158/1535-7163.targ-09-c180","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-09-c180","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023294934","display_name":"Paul A. Moore","orcid":"https://orcid.org/0000-0001-6057-7539","observed_orcids":["https://orcid.org/0000-0001-6057-7539"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Moore","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080629319","display_name":"Ling Huang","orcid":"https://orcid.org/0000-0002-2670-0553","observed_orcids":["https://orcid.org/0000-0002-2670-0553"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Huang","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006469058","display_name":"G. Jonah Rainey","orcid":"https://orcid.org/0000-0002-9906-843X","observed_orcids":["https://orcid.org/0000-0002-9906-843X"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonah Rainey","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenjun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjun Zhang","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103526230","display_name":"Steve Burke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Burke","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118788581","display_name":"Yinhua Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinhua Yang","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056696051","display_name":"Sergey N. Gorlatov","orcid":"https://orcid.org/0000-0002-1430-8765","observed_orcids":["https://orcid.org/0000-0002-1430-8765"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey Gorlatov","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344259","display_name":"Hua Li","orcid":"https://orcid.org/0000-0003-2153-2500","observed_orcids":["https://orcid.org/0000-0003-2153-2500","https://orcid.org/0009-0008-9698-2956"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Li","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110185766","display_name":"Ralph F. Alderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Alderson","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065510563","display_name":"Nadine Tuallion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadine Tuallion","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009027578","display_name":"Ezio Bonvini","orcid":"https://orcid.org/0000-0001-9054-3137","observed_orcids":["https://orcid.org/0000-0001-9054-3137"]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ezio Bonvini","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031117799","display_name":"Syd Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syd Johnson","raw_affiliation_strings":["Macrogenics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macrogenics, Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106297"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"12_Supplement","first_page":"C180","last_page":"C180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bispecific-t-cell-engagers","display_name":"bispecific T-cell engagers","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cd32b","display_name":"CD32B","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-redirection","display_name":"T cell redirection","score":0.6660000085830688},{"id":"https://openalex.org/keywords/nk-cell-redirection","display_name":"NK cell redirection","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mononuclear-phagocytes","display_name":"mononuclear phagocytes","score":0.7310000061988831},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.5950000286102295},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.7489079236984253},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5605263710021973},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5603101849555969},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5041605234146118},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4956563711166382},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48160669207572937},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47168996930122375},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4431777000427246},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4385649263858795},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4249199330806732},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40100017189979553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38234075903892517},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33335232734680176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3322327733039856},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2851773202419281},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2652897238731384},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17501282691955566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11404338479042053}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-09-c180","doi":"https://doi.org/10.1158/1535-7163.targ-09-c180","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-09-c180","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086766201","https://openalex.org/W2081055185","https://openalex.org/W2056362227","https://openalex.org/W2595360873","https://openalex.org/W2727279249","https://openalex.org/W2334567517","https://openalex.org/W298521960","https://openalex.org/W3038016373","https://openalex.org/W2024890197","https://openalex.org/W1544912259"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"significant":[2],"advances":[3],"in":[4,10,79,104,154,182,303,305,313,318,329],"the":[5,13,183,230,256],"treatment":[6],"of":[7,29,33,56,75,132,144,164,173,242],"B-cell":[8,42,151,311,360],"lymphoma,":[9],"many":[11],"cases":[12],"disease":[14],"remains":[15],"untreatable":[16],"or":[17,120,150,176,192,216,284],"displays":[18],"recurrence":[19],"after":[20],"initial":[21],"response":[22],"to":[23,69,110,162,265,345],"therapy.":[24],"The":[25],"recent":[26],"clinical":[27,66],"success":[28],"bi-specific":[30,54],"molecules":[31,60],"capable":[32,131],"redirecting":[34],"T-lymphocyte-mediated":[35],"cytotoxicity":[36],"(Bi-specific":[37],"T-cell":[38],"Engagers,":[39],"BiTEs)":[40],"against":[41,125,137,207,252,274,281,289,359],"lymphoma":[43,152,178,322],"provides":[44],"a":[45,73,80,90,165,208,221,235,239,243,290,340],"feasible":[46],"therapeutic":[47],"option.":[48],"We":[49,96],"have":[50],"developed":[51],"an":[52,157],"alternate":[53],"platform":[55,344],"Dual-Affinity":[57],"Re-Targeting":[58],"(DART)":[59],"that":[61,99,159,163],"is":[62],"well":[63],"suited":[64],"for":[65,223,226,355],"applications.":[67],"Compared":[68],"BiTEs,":[70],"which":[71],"comprise":[72],"pair":[74],"single-chain":[76],"Fv":[77,169],"domains":[78],"single":[81],"polypeptide,":[82],"DARTs":[83,100,299,338],"contain":[84],"two":[85],"separate":[86],"chains":[87],"associated":[88],"into":[89],"heterodimeric,":[91],"covalently":[92],"linked,":[93],"\u2018diabody\u2019":[94],"structure.":[95],"show":[97,300],"here":[98],"are":[101],"very":[102],"stable":[103],"vitro":[105],"and":[106,112,297,325,342],"can":[107],"be":[108],"built":[109],"recruit":[111,346],"retarget":[113],"different":[114,347],"effector":[115,199,218,272],"cells,":[116,124,277],"including":[117,309],"T":[118,135,190],"cells":[119,136,191,196,273,286],"CD16-":[121],"(Fc":[122],"RIII)-positive":[123],"B-cell-lineage":[126],"targets.":[127],"A":[128,259],"CD3xCD19":[129,231],"DART":[130,232,236,261],"recruiting":[133],"cytotoxic":[134],"CD19-positive":[138,253],"targets":[139,254,354],"mediated":[140],"extremely":[141],"potent":[142,279,301],"killing":[143,172,204,228,280,357],"human":[145,319,334],"peripheral":[146,193],"blood":[147,194],"B":[148,276],"lymphocytes":[149],"lines":[153,179],"vitro,":[155],"with":[156,167,213,238,333],"EC50":[158],"compares":[160],"favorably":[161],"BiTE":[166],"identical":[168],"sequences.":[170],"Redirected":[171],"Daudi,":[174,282],"Raji,":[175],"Nalm6":[177],"was":[180,205,249,262],"observed":[181,206],"picomolar":[184],"range":[185],"using":[186],"either":[187,214],"freshly":[188],"purified":[189],"mononuclear":[195,270],"(PBMC)":[197],"as":[198,250,255],"populations.":[200],"In":[201,336],"contrast,":[202],"no":[203],"CD19-negative":[209],"cell":[210,292,323,327,348,352],"line":[211,293],"(RPMI-8226)":[212],"resting":[215],"stimulated":[217],"populations,":[219],"indicating":[220],"requirement":[222],"CD19":[224],"engagement":[225],"T-cell-mediated":[227],"by":[229],"molecule.":[233],"Furthermore,":[234],"constructed":[237,264],"humanized":[240],"version":[241],"pan":[244],"anti-TCR-beta":[245],"antibody":[246],"(TCRxCD19":[247],"DART)":[248],"efficient":[251],"CD3-based":[257],"DART.":[258],"CD16xCD32B":[260],"also":[263],"redirect":[266],"CD16-positive":[267],"NK":[268],"and/or":[269],"phagocyte":[271],"CD32B-positive":[275],"displaying":[278],"Raji":[283,320,326],"RPMI-8226":[285],"but":[287],"not":[288],"CD32B-negative":[291],"(Ramos).":[294],"Both":[295],"TCR-":[296],"CD16-based":[298],"activity":[302],"vivo":[304],"several":[306],"mouse":[307],"models,":[308],"autologous":[310],"depletion":[312],"huCD32B-transgenic":[314],"mice,":[315],"tumor":[316],"reduction":[317],"Burkitt's":[321],"xenografts":[324],"implants":[328],"NOD/SCID":[330],"mice":[331],"reconstituted":[332],"PBMC.":[335],"conclusion,":[337],"represent":[339],"robust":[341],"flexible":[343],"populations":[349],"via":[350],"various":[351],"surface":[353],"re-directed":[356],"applications":[358],"malignancies.":[361],"Citation":[362],"Information:":[363],"Mol":[364],"Cancer":[365],"Ther":[366],"2009;8(12":[367],"Suppl):C180.":[368]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}