{"id":"https://openalex.org/W2090889765","doi":"https://doi.org/10.1056/nejmoa043540","title":"Dose Sparing with Intradermal Injection of Influenza Vaccine","display_name":"Dose Sparing with Intradermal Injection of Influenza Vaccine","publication_year":2004,"publication_date":"2004-11-04","ids":{"openalex":"https://openalex.org/W2090889765","doi":"https://doi.org/10.1056/nejmoa043540","mag":"2090889765","pmid":"https://pubmed.ncbi.nlm.nih.gov/15525714"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa043540","doi":"https://doi.org/10.1056/nejmoa043540","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa043540","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084180707","display_name":"Richard T. Kenney","orcid":"https://orcid.org/0009-0008-6720-3298","observed_orcids":["https://orcid.org/0009-0008-6720-3298"]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard T. Kenney","raw_affiliation_strings":["Iomai, Gaithersburg, Md 20878, USA","Iomai, Gaithersburg, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iomai, Gaithersburg, Md 20878, USA","institution_ids":["https://openalex.org/I4210165951"]},{"raw_affiliation_string":"Iomai, Gaithersburg, Md","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084972288","display_name":"Sarah A. Frech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A. Frech","raw_affiliation_strings":["Iomai, Gaithersburg, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iomai, Gaithersburg, Md","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019729741","display_name":"Larry R. Muenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry R. Muenz","raw_affiliation_strings":["Iomai, Gaithersburg, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iomai, Gaithersburg, Md","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091454762","display_name":"Christina P. Villar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina P. Villar","raw_affiliation_strings":["Iomai, Gaithersburg, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iomai, Gaithersburg, Md","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032295889","display_name":"Gregory M. Glenn","orcid":"https://orcid.org/0000-0002-2030-8665","observed_orcids":["https://orcid.org/0000-0002-2030-8665"]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Glenn","raw_affiliation_strings":["Iomai, Gaithersburg, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iomai, Gaithersburg, Md","institution_ids":["https://openalex.org/I4210165951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210165951"],"apc_list":null,"apc_paid":null,"fwci":15.8184,"has_fulltext":false,"cited_by_count":422,"citation_normalized_percentile":{"value":0.99371897,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"351","issue":"22","first_page":"2295","last_page":"2301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intradermal-vaccination","display_name":"intradermal vaccination","score":0.7990000247955322},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.7329999804496765},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hemagglutination-inhibition-antibodies","display_name":"hemagglutination inhibition antibodies","score":0.8130000233650208},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.8799999952316284},{"id":"https://openalex.org/keywords/seroprotection","display_name":"seroprotection","score":0.9169999957084656},{"id":"https://openalex.org/keywords/vaccine-shortage","display_name":"vaccine shortage","score":0.6460000276565552},{"id":"https://openalex.org/keywords/vaccine-supply","display_name":"vaccine supply","score":0.4169999957084656},{"id":"https://openalex.org/keywords/injection-site-reactions","display_name":"injection site reactions","score":0.6010000109672546},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9537510871887207},{"id":"https://openalex.org/C194051981","wikidata":"https://www.wikidata.org/wiki/Q1337691","display_name":"Economic shortage","level":3,"score":0.7506427764892578},{"id":"https://openalex.org/C2778937273","wikidata":"https://www.wikidata.org/wiki/Q10302254","display_name":"Intradermal injection","level":2,"score":0.6680828332901001},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.6127216219902039},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.43153882026672363},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4178462326526642},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35161322355270386},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.32728710770606995},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26344025135040283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16372480988502502},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2778137410","wikidata":"https://www.wikidata.org/wiki/Q2732820","display_name":"Government (linguistics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009981","descriptor_name":"Influenza B virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejmoa043540","doi":"https://doi.org/10.1056/nejmoa043540","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa043540","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:15525714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15525714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"},{"id":"pmid:15754448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15754448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde","raw_type":"News"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3716569697","display_name":null,"funder_award_id":"2R44-AI45264-02A2","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5165154631","display_name":"Formulated Patch for Topical Influenza Vaccine","funder_award_id":"1r43ai060071-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5567589183","display_name":"Transcutaneous Immunization for Tetanus Booster","funder_award_id":"5r44ai045264-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6224872638","display_name":null,"funder_award_id":"1R43-AI060071-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1536181655","https://openalex.org/W1971462013","https://openalex.org/W1976797474","https://openalex.org/W2042220448","https://openalex.org/W2064391381","https://openalex.org/W2072518656","https://openalex.org/W2092998089","https://openalex.org/W2107587363","https://openalex.org/W2123156812","https://openalex.org/W2134940298","https://openalex.org/W2143110355","https://openalex.org/W2149821903","https://openalex.org/W2160841179","https://openalex.org/W2167474512","https://openalex.org/W2170456252","https://openalex.org/W2414313173","https://openalex.org/W2419577347","https://openalex.org/W4239192913"],"related_works":["https://openalex.org/W3126857517","https://openalex.org/W2114833733","https://openalex.org/W1993304502","https://openalex.org/W2016143593","https://openalex.org/W2082436249","https://openalex.org/W2142212499","https://openalex.org/W1964841465","https://openalex.org/W2045992337","https://openalex.org/W2122868020","https://openalex.org/W2081182462"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"loss":[2],"of":[3,8,25,52,60,81,84,93,99,108,116,122,174,189,203,234,243,280,286,300,305,312,339],"half":[4],"the":[5,41,56,130,135,159,186,195,206,210,214,220,240,244,254,308,337],"U.S.":[6],"supply":[7],"influenza":[9,42,64,86,190,314,340],"vaccine":[10,65,191,315],"due":[11],"to":[12,31,49,54,74,151,263,268,321,335],"contamination":[13],"has":[14],"created":[15],"a":[16,36,77,100,104,123,201,232],"critical":[17],"shortage.":[18],"Dose-sparing":[19],"strategies":[20],"that":[21,318,325],"use":[22],"intradermal":[23,61,106,181,281,303],"delivery":[24],"vaccines":[26],"may":[27],"be":[28,333,351],"one":[29,184,306],"approach":[30],"consider.":[32],"METHODS:":[33],"We":[34],"conducted":[35],"randomized,":[37],"open-label":[38],"trial":[39],"outside":[40],"season":[43],"in":[44,129,134,158,194,209,253],"100":[45,269],"healthy":[46],"adults":[47],"18":[48],"40":[50],"years":[51],"age":[53],"compare":[55],"immunogenicity":[57,317],"and":[58,147,154,161,165,217,237,248,266,294],"safety":[59],"immunization":[62],"with":[63,66,183,228],"standard":[67,187,245,309],"intramuscular":[68,79,241,287,310,328],"immunization.":[69],"Subjects":[70,177],"were":[71,128,140,169,251,274,292],"randomly":[72],"assigned":[73],"receive":[75],"either":[76],"single":[78,105],"dose":[80,107,188,311],"0.5":[82],"ml":[83],"trivalent":[85],"vaccine,":[87,211,341],"containing":[88,111],"at":[89,112],"least":[90,113],"15":[91],"microg":[92,115],"hemagglutinin":[94,117],"per":[95,118],"strain,":[96,119,216],"by":[97,120,142,155,200,231,327],"means":[98,121],"prefilled":[101],"syringe":[102],"or":[103,322],"0.1":[109],"ml,":[110],"3":[114],"fine-gauge":[124],"needle;":[125],"both":[126,172],"injections":[127,282],"deltoid":[131],"region.":[132],"Changes":[133],"hemagglutination-inhibition":[136],"(HAI)":[137],"antibody":[138],"titer":[139,199],"assessed":[141,170],"comparing":[143,156],"geometric":[144,196],"mean":[145,197],"titers":[146],"fold":[148],"increases":[149,193,230],"relative":[150],"baseline":[152],"values":[153],"changes":[157],"seroconversion":[160],"seroprotection":[162,249],"rates.":[163],"Local":[164,272],"systemic":[166],"adverse":[167],"events":[168],"after":[171],"types":[173],"vaccination.":[175],"RESULTS:":[176],"who":[178],"received":[179],"an":[180,313],"injection":[182,242],"fifth":[185,307],"had":[192],"HAI":[198],"factor":[202,233],"15.2":[204],"for":[205,213,219,239,353],"H1N1":[207],"strain":[208,222],"19.0":[212],"H3N2":[215],"12.4":[218],"B":[221],"on":[223,257],"day":[224,258],"21,":[225,259],"as":[226],"compared":[227],"respective":[229],"14.9,":[235],"7.1,":[236],"15.3":[238],"dose.":[246],"Seroconversion":[247],"rates":[250],"similar":[252,320],"two":[255],"groups":[256],"ranging":[260],"from":[261],"66":[262],"82":[264],"percent":[265],"84":[267],"percent,":[270],"respectively.":[271],"reactions":[273,291],"significantly":[275],"more":[276],"frequent":[277],"among":[278,284],"recipients":[279,285],"than":[283,324],"injections,":[288],"but":[289,342],"such":[290],"mild":[293],"transient.":[295],"CONCLUSIONS:":[296],"In":[297],"this":[298,348],"study":[299],"young":[301],"adults,":[302],"administration":[304,331],"elicited":[316,326],"was":[319],"better":[323],"injection.":[329],"Intradermal":[330],"could":[332],"used":[334],"expand":[336],"supplies":[338],"further":[343],"studies":[344],"are":[345],"needed":[346],"before":[347],"strategy":[349],"can":[350],"recommended":[352],"routine":[354],"use.":[355]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":29}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}