{"id":"https://openalex.org/W2090858","doi":null,"title":"Targeting the hedgehog pathway to treat basal cell carcinoma.","display_name":"Targeting the hedgehog pathway to treat basal cell carcinoma.","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2090858","mag":"2090858","pmid":"https://pubmed.ncbi.nlm.nih.gov/23652945"},"language":"en","primary_location":{"id":"pmid:23652945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23652945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118975845","display_name":"Pieter Geeraert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pieter Geeraert","raw_affiliation_strings":["Department of Radiology, University Hospital, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Hospital, Brussels, Belgium","institution_ids":["https://openalex.org/I4210126764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014878886","display_name":"Jonathan S. Williams","orcid":"https://orcid.org/0000-0001-7152-765X","observed_orcids":["https://orcid.org/0000-0001-7152-765X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan S Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039497310","display_name":"Isaac Brownell","orcid":"https://orcid.org/0000-0002-0090-9914","observed_orcids":["https://orcid.org/0000-0002-0090-9914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isaac Brownell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3299,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52591035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"5","first_page":"519","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vismodegib","display_name":"vismodegib","score":0.878000020980835},{"id":"https://openalex.org/keywords/smoothened-inhibitor","display_name":"Smoothened inhibitors","score":0.8569999933242798},{"id":"https://openalex.org/keywords/smo-antagonists","display_name":"SMO antagonists","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gorlin-syndrome","display_name":"Gorlin syndrome","score":0.9039999842643738},{"id":"https://openalex.org/keywords/advanced-basal-cell-carcinoma","display_name":"advanced basal cell carcinoma","score":0.875},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8289999961853027},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.7129999995231628},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2779545874","wikidata":"https://www.wikidata.org/wiki/Q2070286","display_name":"Vismodegib","level":4,"score":0.9958198070526123},{"id":"https://openalex.org/C145837895","wikidata":"https://www.wikidata.org/wiki/Q18031607","display_name":"Smoothened","level":4,"score":0.9757339954376221},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.8799207806587219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8492909669876099},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.8477722406387329},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7216981649398804},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.6898812651634216},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5519855618476868},{"id":"https://openalex.org/C2909761261","wikidata":"https://www.wikidata.org/wiki/Q1536720","display_name":"Basal Cell Nevus Syndrome","level":4,"score":0.515086829662323},{"id":"https://openalex.org/C2779477247","wikidata":"https://www.wikidata.org/wiki/Q18030895","display_name":"PTCH1","level":4,"score":0.46428385376930237},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3838501572608948},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36720049381256104},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.365800678730011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31990188360214233},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3111306428909302},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2487412393093109},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.17871582508087158},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15106409788131714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1106322705745697}],"mesh":[{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001478","descriptor_name":"Basal Cell Nevus Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001478","descriptor_name":"Basal Cell Nevus Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23652945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23652945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"},{"id":"mag:2090858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23652945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2282601220","https://openalex.org/W2110705645","https://openalex.org/W2754869681","https://openalex.org/W2070902733","https://openalex.org/W4200011977","https://openalex.org/W2110967174","https://openalex.org/W2093518411","https://openalex.org/W2041330527","https://openalex.org/W2101938392","https://openalex.org/W2588244614"],"abstract_inverted_index":{"The":[0],"discovery":[1],"of":[2,21,36,53,89,99,110],"mutations":[3],"that":[4,25,39],"activate":[5],"hedgehog":[6],"(Hh)":[7],"signaling":[8,49],"in":[9,46,60,96],"basal":[10,105],"cell":[11,106],"carcinoma":[12],"(BCC)":[13],"and":[14,77,91,104,116],"other":[15,92],"cancers":[16],"has":[17],"spurred":[18],"the":[19,27,47,54,74,85,97],"development":[20],"small":[22],"molecule":[23],"inhibitors":[24,95],"target":[26],"Hh":[28,48,93],"pathway.":[29,50],"High-throughput":[30],"screens":[31],"have":[32,67],"identified":[33],"a":[34],"number":[35],"drug":[37,111],"candidates":[38],"antagonize":[40],"smoothened":[41],"(SMO),":[42],"an":[43,87],"essential":[44],"protein":[45],"Clinical":[51],"studies":[52],"oral":[55],"SMO":[56],"inhibitor":[57],"vismodegib":[58,90],"(GDC-0449)":[59],"patients":[61,100],"with":[62,101],"inoperable":[63],"or":[64],"metastatic":[65],"BCC":[66,103],"led":[68],"to":[69,83],"its":[70],"recent":[71],"approval":[72],"by":[73],"US":[75],"Food":[76],"Drug":[78],"Administration.":[79],"This":[80],"review":[81],"aims":[82],"give":[84],"clinician":[86],"overview":[88],"pathway":[94],"treatment":[98],"advanced":[102],"nevus":[107],"syndrome.":[108],"Issues":[109],"mechanism,":[112],"efficacy,":[113],"safety,":[114],"tolerability,":[115],"tumor":[117],"resistance":[118],"are":[119],"addressed.":[120]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
