{"id":"https://openalex.org/W2090857211","doi":"https://doi.org/10.1016/s0378-5173(99)00370-1","title":"Desolvation process and surface characterisation of protein nanoparticles","display_name":"Desolvation process and surface characterisation of protein nanoparticles","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2090857211","doi":"https://doi.org/10.1016/s0378-5173(99)00370-1","mag":"2090857211","pmid":"https://pubmed.ncbi.nlm.nih.gov/10601688"},"language":"en","primary_location":{"id":"doi:10.1016/s0378-5173(99)00370-1","doi":"https://doi.org/10.1016/s0378-5173(99)00370-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0378-5173(99)00370-1","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005002428","display_name":"Carolin Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Weber","raw_affiliation_strings":["Institut f]ur Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit]at, Marie-Curie-Strasse 9, D-60439, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f]ur Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit]at, Marie-Curie-Strasse 9, D-60439, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044787105","display_name":"Conrad Coester","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Coester","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit\u00e4t, Marie-Curie-Stra\u00dfe 9, D-60439, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit\u00e4t, Marie-Curie-Stra\u00dfe 9, D-60439, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112807703","display_name":"J. Kreuter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Kreuter","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit\u00e4t, Marie-Curie-Stra\u00dfe 9, D-60439, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit\u00e4t, Marie-Curie-Stra\u00dfe 9, D-60439, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029985164","display_name":"Klaus Langer","orcid":"https://orcid.org/0000-0002-0203-7478","observed_orcids":["https://orcid.org/0000-0002-0203-7478"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"K Langer","raw_affiliation_strings":["Institut f\u00fcr Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit\u00e4t, Marie-Curie-Stra\u00dfe 9, D-60439, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe-Universit\u00e4t, Marie-Curie-Stra\u00dfe 9, D-60439, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029985164"],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":9.9111,"has_fulltext":false,"cited_by_count":614,"citation_normalized_percentile":{"value":0.98471894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"194","issue":"1","first_page":"91","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.25780001282691956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.24009999632835388,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-nanoparticles","display_name":"protein nanoparticles","score":0.7829999923706055},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/desolvation","display_name":"desolvation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.9589999914169312},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/surface-amino-groups","display_name":"surface amino groups","score":0.8709999918937683},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.9309999942779541},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.9739999771118164},{"id":"https://openalex.org/keywords/colloidal-stability","display_name":"colloidal stability","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gelatin-nanoparticles","display_name":"gelatin nanoparticles","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.8765532970428467},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.8719459772109985},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.7953816652297974},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.6858540773391724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6721419095993042},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.6277270317077637},{"id":"https://openalex.org/C2776923230","wikidata":"https://www.wikidata.org/wiki/Q16955798","display_name":"Denaturation (fissile materials)","level":2,"score":0.6270856261253357},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.5009722709655762},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.4709136188030243},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4180886745452881},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.31451237201690674},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2538328468799591},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.09455326199531555},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003102","descriptor_name":"Colloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005976","descriptor_name":"Glutaral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014302","descriptor_name":"Trinitrobenzenesulfonic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0378-5173(99)00370-1","doi":"https://doi.org/10.1016/s0378-5173(99)00370-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0378-5173(99)00370-1","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:10601688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10601688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W36687287","https://openalex.org/W131472275","https://openalex.org/W297750265","https://openalex.org/W1498773598","https://openalex.org/W1504792186","https://openalex.org/W1982568915","https://openalex.org/W1991031656","https://openalex.org/W1994483910","https://openalex.org/W1994561089","https://openalex.org/W2003349363","https://openalex.org/W2009119064","https://openalex.org/W2010178116","https://openalex.org/W2023505841","https://openalex.org/W2030304099","https://openalex.org/W2035083579","https://openalex.org/W2037008627","https://openalex.org/W2057057376","https://openalex.org/W2058574835","https://openalex.org/W2129955028","https://openalex.org/W2152952586","https://openalex.org/W2156522410","https://openalex.org/W2320681805","https://openalex.org/W2332562159","https://openalex.org/W2402719599","https://openalex.org/W2466279822"],"related_works":["https://openalex.org/W2019366306","https://openalex.org/W2072397117","https://openalex.org/W7098120814","https://openalex.org/W2275094369","https://openalex.org/W2040451408","https://openalex.org/W2363542542","https://openalex.org/W2955054605","https://openalex.org/W2007192377","https://openalex.org/W4406436975","https://openalex.org/W2056710125"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":46},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":37},{"year":2016,"cited_by_count":51},{"year":2015,"cited_by_count":40},{"year":2014,"cited_by_count":38},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}