{"id":"https://openalex.org/W2090854907","doi":"https://doi.org/10.1534/genetics.109.107268","title":"Transient Genotype-by-Environment Interactions Following Environmental Shock Provide a Source of Expression Variation for Essential Genes","display_name":"Transient Genotype-by-Environment Interactions Following Environmental Shock Provide a Source of Expression Variation for Essential Genes","publication_year":2009,"publication_date":"2009-12-05","ids":{"openalex":"https://openalex.org/W2090854907","doi":"https://doi.org/10.1534/genetics.109.107268","mag":"2090854907","pmid":"https://pubmed.ncbi.nlm.nih.gov/19966067","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828734"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.109.107268","doi":"https://doi.org/10.1534/genetics.109.107268","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.109.107268","pdf_url":"https://academic.oup.com/genetics/article-pdf/184/2/587/42173633/genetics0587.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/genetics/article-pdf/184/2/587/42173633/genetics0587.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034560158","display_name":"Kevin Hasegawa Eng","orcid":"https://orcid.org/0000-0001-5636-0812","observed_orcids":["https://orcid.org/0000-0001-5636-0812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin H Eng","raw_affiliation_strings":["Department of Statistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016787543","display_name":"Daniel J. Kvitek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J Kvitek","raw_affiliation_strings":["Laboratory of Genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027290261","display_name":"S\u00fcnd\u00fcz Kele\u015f","orcid":"https://orcid.org/0000-0001-9048-0922","observed_orcids":["https://orcid.org/0000-0001-9048-0922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Su\u0308ndu\u0308z Keles\u0327","raw_affiliation_strings":["Department of Biostatistics and Medical Informatics","Department of Statistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics","institution_ids":[]},{"raw_affiliation_string":"Department of Statistics","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048778946","display_name":"Audrey P. Gasch","orcid":"https://orcid.org/0000-0002-8182-257X","observed_orcids":["https://orcid.org/0000-0002-8182-257X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Audrey P Gasch","raw_affiliation_strings":["Genome Center of Wisconsin, University of Wisconsin, Madison, Wisconsin 53706","Laboratory of Genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Center of Wisconsin, University of Wisconsin, Madison, Wisconsin 53706","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Laboratory of Genetics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048778946"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.875,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.70515702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"184","issue":"2","first_page":"587","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.48100000619888306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.48100000619888306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.23100000619888306,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.10040000081062317,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gene-expression-variation","display_name":"gene expression variation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.8059999942779541},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9520000219345093},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/non-essential-genes","display_name":"non-essential genes","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.8389999866485596},{"id":"https://openalex.org/keywords/environmental-acclimation","display_name":"environmental acclimation","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8413392305374146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7628343105316162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7294973731040955},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6238818764686584},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5799883008003235},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5245023965835571},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4800040125846863},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4422563314437866},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.4254506826400757},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.42040741443634033},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4124869406223297},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1534/genetics.109.107268","doi":"https://doi.org/10.1534/genetics.109.107268","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.109.107268","pdf_url":"https://academic.oup.com/genetics/article-pdf/184/2/587/42173633/genetics0587.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1909282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2828734","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828734","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmid:19966067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19966067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1534/genetics.109.107268","doi":"https://doi.org/10.1534/genetics.109.107268","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.109.107268","pdf_url":"https://academic.oup.com/genetics/article-pdf/184/2/587/42173633/genetics0587.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5961890981","display_name":"High dimensional statistical data modeling and integration for studying regulatory variation","funder_award_id":"R01HG003747","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7429372411","display_name":null,"funder_award_id":"HG003747","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000887391","display_name":"Institutional Training Grant in Genome Science","funder_award_id":"T32HG000044","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090854907.pdf","grobid_xml":"https://content.openalex.org/works/W2090854907.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1555578917","https://openalex.org/W1981442331","https://openalex.org/W1995340594","https://openalex.org/W1997839385","https://openalex.org/W2015312982","https://openalex.org/W2016786878","https://openalex.org/W2037594820","https://openalex.org/W2037652809","https://openalex.org/W2038225430","https://openalex.org/W2044044072","https://openalex.org/W2048258507","https://openalex.org/W2079319076","https://openalex.org/W2081719540","https://openalex.org/W2084695584","https://openalex.org/W2088014737","https://openalex.org/W2089114713","https://openalex.org/W2090803844","https://openalex.org/W2094902224","https://openalex.org/W2097782352","https://openalex.org/W2104254337","https://openalex.org/W2106601849","https://openalex.org/W2110065044","https://openalex.org/W2120423098","https://openalex.org/W2121331980","https://openalex.org/W2127013070","https://openalex.org/W2137683543","https://openalex.org/W2140948740","https://openalex.org/W2143941462","https://openalex.org/W2151233592","https://openalex.org/W2165081628","https://openalex.org/W2171327609","https://openalex.org/W2325325200"],"related_works":["https://openalex.org/W1997839385","https://openalex.org/W2038225430","https://openalex.org/W7098162202","https://openalex.org/W7096143998","https://openalex.org/W2113905284","https://openalex.org/W7095132060","https://openalex.org/W2146096926","https://openalex.org/W4206399077","https://openalex.org/W1995340594","https://openalex.org/W1573727656"],"abstract_inverted_index":{"Understanding":[0],"complex":[1],"genotype-by-environment":[2],"interactions":[3],"(GEIs)":[4],"is":[5,19],"crucial":[6],"for":[7,107,120,173],"understanding":[8],"phenotypic":[9],"variation.":[10],"An":[11],"important":[12],"factor":[13],"often":[14],"overlooked":[15],"in":[16,30,78],"GEI":[17,46,68,103,131,158],"studies":[18],"time.":[20],"We":[21,154],"measured":[22],"the":[23,57,72,142,160],"contribution":[24],"of":[25,56,63,90,94,124,169],"GEIs":[26,117,151],"to":[27,38,101,129,141,149],"expression":[28,52,65,89,139,170],"variation":[29],"four":[31],"nonlaboratory":[32],"Saccharomyces":[33],"cerevisiae":[34],"strains":[35],"responding":[36],"dynamically":[37],"a":[39,48,84,91,165],"25":[40],"degrees":[41,43],"-37":[42],"heat":[44],"shock.":[45],"was":[47],"major":[49],"force":[50],"explaining":[51],"variation,":[53,171],"affecting":[54],"55%":[55],"genes":[58,109,122,147],"analyzed.":[59],"Importantly,":[60],"almost":[61],"half":[62],"these":[64],"patterns":[66],"showed":[67,133],"influence":[69],"only":[70],"during":[71,159],"transition":[73,161],"between":[74,162],"environments,":[75],"but":[76],"not":[77],"acclimated":[79,137],"cells.":[80],"This":[81],"class":[82],"reveals":[83],"genotype-by-environment-by-time":[85],"interaction":[86],"that":[87,156],"affected":[88],"large":[92],"fraction":[93],"yeast":[95,144],"genes.":[96,175],"Strikingly,":[97],"although":[98],"transcripts":[99],"subject":[100,128],"persistent":[102,130],"effects":[104],"were":[105,118],"enriched":[106,119],"nonessential":[108],"with":[110],"upstream":[111],"TATA":[112,125],"elements,":[113],"those":[114],"displaying":[115],"transient":[116,150,157],"essential":[121,174],"regardless":[123],"regulation.":[126],"Genes":[127],"influences":[132],"relaxed":[134],"constraint":[135],"on":[136],"gene":[138],"compared":[140],"average":[143],"gene,":[145],"whereas":[146],"restricted":[148],"did":[152],"not.":[153],"propose":[155],"environments":[163],"provides":[164],"previously":[166],"unappreciated":[167],"source":[168],"particularly":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
