{"id":"https://openalex.org/W2090843392","doi":"https://doi.org/10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","title":"Weekly high-dose methotrexate-citrovorum factor in osteogenic sarcoma.Pre-surgical treatment of primary tumor and of overt pulmonary metastases","display_name":"Weekly high-dose methotrexate-citrovorum factor in osteogenic sarcoma.Pre-surgical treatment of primary tumor and of overt pulmonary metastases","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2090843392","doi":"https://doi.org/10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","mag":"2090843392","pmid":"https://pubmed.ncbi.nlm.nih.gov/299828"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","doi":"https://doi.org/10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109950215","display_name":"Norman Jaffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Jaffe","raw_affiliation_strings":["Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113497738","display_name":"E Frei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emil Frei","raw_affiliation_strings":["Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055790431","display_name":"Demetrius Traggis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Demetrius Traggis","raw_affiliation_strings":["Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108553806","display_name":"Hugh G. Watts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugh Watts","raw_affiliation_strings":["Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center (Department of Orthopedic Surgery), Sidney Farber Cancer Center, and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":9.7947,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.98541353,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"39","issue":"1","first_page":"45","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.9319999814033508},{"id":"https://openalex.org/keywords/citrovorum-factor","display_name":"citrovorum factor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/weekly-chemotherapy","display_name":"weekly chemotherapy","score":0.5350000262260437},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/limb-sparing-surgery","display_name":"limb-sparing surgery","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5720000267028809},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9793593883514404},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.7087414264678955},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5798109769821167},{"id":"https://openalex.org/C2779051857","wikidata":"https://www.wikidata.org/wiki/Q911386","display_name":"Stomatitis","level":2,"score":0.5724118947982788},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5508357882499695},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5158047676086426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4229970872402191},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.41311895847320557},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3937574028968811},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.12150713801383972}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012075","descriptor_name":"Remission, Spontaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","doi":"https://doi.org/10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(197701)39:1<45::aid-cncr2820390109>3.0.co;2-t","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:299828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/299828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1907860673","https://openalex.org/W1965076953","https://openalex.org/W1976734173","https://openalex.org/W2052512461","https://openalex.org/W2066411630","https://openalex.org/W2082784075","https://openalex.org/W2082910236","https://openalex.org/W2090484555","https://openalex.org/W2317833459","https://openalex.org/W2429040210"],"related_works":["https://openalex.org/W2403907339","https://openalex.org/W1974907966","https://openalex.org/W2043304162","https://openalex.org/W2082784075","https://openalex.org/W2000265889","https://openalex.org/W2317833459","https://openalex.org/W2003180293","https://openalex.org/W1991169033","https://openalex.org/W2414158663","https://openalex.org/W1975126592"],"abstract_inverted_index":{"Vincristine-high-dose":[0],"methotrexate-citrovorum":[1],"factor":[2],"(VCR-MTX-CF)":[3],"was":[4,34,67,118,137],"administered":[5,35],"preoperatively":[6],"at":[7],"weekly":[8,135],"intervals":[9],"to":[10,36,142],"eight":[11,49],"patients,":[12],"four":[13,18],"with":[14,19,39,63,74,102,145],"primary":[15,64],"tumors":[16,65],"and":[17,72,97,112,120,130],"pulmonary":[20,40,75],"metastases.":[21,76],"These":[22],"patients":[23,38,50,91],"had":[24,43,52,93],"not":[25,53],"received":[26,44,54,94],"prior":[27,45,55],"VCR-MTX-CF":[28],"treatment.":[29],"A":[30],"similar":[31],"treatment":[32],"program":[33,136],"five":[37],"metastases":[41],"who":[42,51,92],"VCR-MTX-CF.":[46,95],"Among":[47],"the":[48,110,146],"VCR-MTX-CF,":[56],"complete":[57],"responses":[58,78,85,143],"were":[59,86],"obtained":[60,88,144],"in":[61,80,89,99,107,150],"three":[62],"(this":[66],"followed":[68],"by":[69],"surgical":[70],"excision)":[71],"two":[73,81,90],"Partial":[77,84],"occurred":[79],"additional":[82],"patients.":[83],"also":[87],"Chemotherapy":[96],"surgery":[98],"one":[100],"patient":[101],"an":[103],"extremity":[104],"lesion":[105],"resulted":[106],"preservation":[108],"of":[109],"limb":[111],"useful":[113],"function.":[114],"The":[115,134],"major":[116],"toxicity":[117],"anorexia":[119],"weight":[121],"loss.":[122],"Other":[123],"side":[124],"effects":[125],"included":[126],"stomatitis,":[127],"myelosuppression,":[128],"hepatitis":[129],"transient":[131],"renal":[132],"impairment.":[133],"highly":[138],"effective":[139],"when":[140],"compared":[141],"tri-weekly":[147],"schedule":[148],"utilized":[149],"previous":[151],"studies.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}