{"id":"https://openalex.org/W2090839765","doi":"https://doi.org/10.1093/nar/13.6.1871","title":"Sequence requirements for self-splicing of theTetrahymena thermophilapre-ribosomal RNA","display_name":"Sequence requirements for self-splicing of theTetrahymena thermophilapre-ribosomal RNA","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2090839765","doi":"https://doi.org/10.1093/nar/13.6.1871","mag":"2090839765","pmid":"https://pubmed.ncbi.nlm.nih.gov/4000946","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/341122"},"language":"en","primary_location":{"id":"doi:10.1093/nar/13.6.1871","doi":"https://doi.org/10.1093/nar/13.6.1871","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/13.6.1871","pdf_url":"https://academic.oup.com/nar/article-pdf/13/6/1871/7057556/13-6-1871.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/13/6/1871/7057556/13-6-1871.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037905421","display_name":"James V. Price","orcid":"https://orcid.org/0000-0001-9068-7317","observed_orcids":["https://orcid.org/0000-0001-9068-7317"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James V. Price","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology Boulder, CO 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056314878","display_name":"Gary L. Kieft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L. Kieft","raw_affiliation_strings":["Department of Chemistry, University of Colorado Boulder, CO 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Colorado Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028262547","display_name":"Jeffrey R. Kent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Kent","raw_affiliation_strings":["Department of Chemistry, University of Colorado Boulder, CO 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Colorado Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031662456","display_name":"Eric L. Sievers","orcid":"https://orcid.org/0000-0002-0794-9441","observed_orcids":["https://orcid.org/0000-0002-0794-9441"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Sievers","raw_affiliation_strings":["Department of Chemistry, University of Colorado Boulder, CO 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Colorado Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017573996","display_name":"Thomas R. Cech","orcid":"https://orcid.org/0000-0001-7338-3389","observed_orcids":["https://orcid.org/0000-0001-7338-3389"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Cech","raw_affiliation_strings":["Department of Chemistry, University of Colorado Boulder, CO 80309, USA","Department of Molecular, Cellular and Developmental Biology Boulder, CO 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Colorado Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":3.7235,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.94526386,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":"6","first_page":"1871","last_page":"1889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-splicing","display_name":"self-splicing","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tetrahymena-thermophila","display_name":"Tetrahymena thermophila","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ribosomal-dna","display_name":"ribosomal DNA","score":0.8370000123977661},{"id":"https://openalex.org/keywords/introns","display_name":"introns","score":0.8989999890327454},{"id":"https://openalex.org/keywords/3-splice-site","display_name":"3' splice site","score":0.7620000243186951},{"id":"https://openalex.org/keywords/sequence-requirements","display_name":"sequence requirements","score":0.5509999990463257},{"id":"https://openalex.org/keywords/stem-loop-structure","display_name":"stem-loop structure","score":0.8960000276565552},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2777166614","wikidata":"https://www.wikidata.org/wiki/Q1198419","display_name":"Tetrahymena","level":2,"score":0.609984815120697},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5474768280982971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4738783538341522},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.4323086738586426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26270127296447754},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24764469265937805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14301437139511108}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013768","descriptor_name":"Tetrahymena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/13.6.1871","doi":"https://doi.org/10.1093/nar/13.6.1871","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/13.6.1871","pdf_url":"https://academic.oup.com/nar/article-pdf/13/6/1871/7057556/13-6-1871.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:341122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/341122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:4000946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4000946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.867.1722","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.867.1722","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/13/6/1871.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/nar/13.6.1871","doi":"https://doi.org/10.1093/nar/13.6.1871","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/13.6.1871","pdf_url":"https://academic.oup.com/nar/article-pdf/13/6/1871/7057556/13-6-1871.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2222028608","display_name":null,"funder_award_id":"GM 28039","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320309070","display_name":"Brown University","ror":"https://ror.org/05gq02987"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090839765.pdf","grobid_xml":"https://content.openalex.org/works/W2090839765.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1516266635","https://openalex.org/W1590677545","https://openalex.org/W1602364274","https://openalex.org/W1964915470","https://openalex.org/W1968282235","https://openalex.org/W1969108251","https://openalex.org/W1969292324","https://openalex.org/W1979496015","https://openalex.org/W1989482194","https://openalex.org/W1993667465","https://openalex.org/W1993725313","https://openalex.org/W2002502414","https://openalex.org/W2016970512","https://openalex.org/W2028335053","https://openalex.org/W2032578351","https://openalex.org/W2032776824","https://openalex.org/W2051281883","https://openalex.org/W2055357838","https://openalex.org/W2060578134","https://openalex.org/W2063539244","https://openalex.org/W2072229642","https://openalex.org/W2078119356","https://openalex.org/W2080119769","https://openalex.org/W2088731210","https://openalex.org/W2094374039","https://openalex.org/W2095120711","https://openalex.org/W2097971843","https://openalex.org/W2339662051"],"related_works":["https://openalex.org/W7099195147","https://openalex.org/W2030453506","https://openalex.org/W2062826894","https://openalex.org/W2100655288","https://openalex.org/W1968282235","https://openalex.org/W2102575752","https://openalex.org/W2157133767","https://openalex.org/W1580007630","https://openalex.org/W2328759390","https://openalex.org/W2133569537"],"abstract_inverted_index":{"The":[0,30,135,157],"sequence":[1,28,148],"requirements":[2],"for":[3,39,122,140,159,164],"splicing":[4,166],"of":[5,45,59,71,79,103,154,176],"the":[6,14,26,36,69,72,77,80,85,100,146,162,172],"Tetrahymena":[7],"pre-rRNA":[8,165],"have":[9],"been":[10],"examined":[11],"by":[12,92],"altering":[13],"rRNA":[15],"gene":[16],"to":[17,132,145,171],"produce":[18],"versions":[19],"that":[20,118,137,150],"contain":[21],"insertions":[22,46],"and":[23,35,115],"deletions":[24,104],"within":[25,99,161],"intervening":[27,155],"(IVS).":[29],"altered":[31],"genes":[32],"were":[33,130],"transcribed":[34],"RNA":[37],"tested":[38],"self-splicing":[40,56,141],"in":[41,125,168,179],"vitro.":[42,126],"A":[43],"number":[44],"(8-54":[47],"nucleotides)":[48],"at":[49,63,106],"three":[50],"locations":[51],"had":[52],"no":[53],"effect":[54],"on":[55],"activity.":[57],"Two":[58],"these":[60],"insertions,":[61],"located":[62],"a":[64,96,112,116],"site":[65,88],"5":[66],"nucleotides":[67],"preceding":[68],"3'-end":[70],"IVS,":[73],"did":[74],"not":[75,90,143],"alter":[76],"choice":[78],"3'":[81,86],"splice":[82,87],"site.":[83],"Thus":[84],"is":[89,167],"chosen":[91],"its":[93],"distance":[94],"from":[95],"fixed":[97],"point":[98],"IVS.":[101],"Analysis":[102],"constructed":[105],"two":[107,110],"sites":[108],"revealed":[109],"structures,":[111],"hairpin":[113],"loop":[114],"stem-loop,":[117],"are":[119,138,142],"entirely":[120],"dispensable":[121],"IVS":[123,163,177],"excision":[124],"Three":[127],"other":[128],"regions":[129,136],"found":[131],"be":[133],"necessary.":[134],"important":[139],"restricted":[144],"conserved":[147],"elements":[149],"define":[151],"this":[152],"class":[153],"sequences.":[156],"requirement":[158],"structures":[160],"sharp":[169],"contrast":[170],"very":[173],"limited":[174],"role":[175],"structure":[178],"nuclear":[180],"pre-mRNA":[181],"splicing.":[182]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
