{"id":"https://openalex.org/W2090798613","doi":"https://doi.org/10.1021/pr3007705","title":"Feasibility of Identifying the Tobacco-related Global Metabolome in Blood by UPLC\u2013QTOF-MS","display_name":"Feasibility of Identifying the Tobacco-related Global Metabolome in Blood by UPLC\u2013QTOF-MS","publication_year":2012,"publication_date":"2012-12-17","ids":{"openalex":"https://openalex.org/W2090798613","doi":"https://doi.org/10.1021/pr3007705","mag":"2090798613","pmid":"https://pubmed.ncbi.nlm.nih.gov/23240883","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3579455"},"language":"en","primary_location":{"id":"doi:10.1021/pr3007705","doi":"https://doi.org/10.1021/pr3007705","is_oa":true,"landing_page_url":"https://doi.org/10.1021/pr3007705","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/pr3007705?ref=article_openPDF","source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/pr3007705?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040281765","display_name":"Ping-Ching Hsu","orcid":"https://orcid.org/0000-0002-1749-0662","observed_orcids":["https://orcid.org/0000-0002-1749-0662"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping-Ching Hsu","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083108695","display_name":"Bin Zhou","orcid":"https://orcid.org/0000-0003-3642-2048","observed_orcids":["https://orcid.org/0000-0003-3642-2048"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Zhou","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000991048","display_name":"Yi Chen Zhao","orcid":"https://orcid.org/0000-0001-6046-8420","observed_orcids":["https://orcid.org/0000-0001-6046-8420"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zhao","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125310","display_name":"Habtom W. Ressom","orcid":"https://orcid.org/0000-0001-9296-2132","observed_orcids":["https://orcid.org/0000-0001-9296-2132"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habtom W. Ressom","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003800447","display_name":"Amrita K. Cheema","orcid":"https://orcid.org/0000-0003-4877-7583","observed_orcids":["https://orcid.org/0000-0003-4877-7583"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita K. Cheema","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Comprehensive#R#Cancer#R#Center, Georgetown University, Washington,#R#D.C., United States","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088899243","display_name":"Wallace B. Pickworth","orcid":"https://orcid.org/0000-0003-3310-2567","observed_orcids":["https://orcid.org/0000-0003-3310-2567"]},"institutions":[{"id":"https://openalex.org/I1325736334","display_name":"Battelle","ror":"https://ror.org/01h5tnr73","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1325736334"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace Pickworth","raw_affiliation_strings":["Battelle Centers for Public Health Research & Evaluation, Baltimore, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Battelle Centers for Public Health Research & Evaluation, Baltimore, Maryland, United States","institution_ids":["https://openalex.org/I1325736334"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079716545","display_name":"Peter G. Shields","orcid":"https://orcid.org/0000-0002-7404-217X","observed_orcids":["https://orcid.org/0000-0002-7404-217X"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter G. Shields","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States","The Ohio State University Comprehensive Cancer Center, Columbus, Ohio,#R#United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States","institution_ids":["https://openalex.org/I2799885155"]},{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, Ohio,#R#United States","institution_ids":["https://openalex.org/I2799885155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079716545"],"corresponding_institution_ids":["https://openalex.org/I2799885155"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.6849,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.83688367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"2","first_page":"679","last_page":"691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tobacco-smoke-exposure","display_name":"tobacco smoke exposure","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.5370000004768372},{"id":"https://openalex.org/keywords/blood-metabolome","display_name":"blood metabolome","score":0.8299999833106995},{"id":"https://openalex.org/keywords/plasma-metabolites","display_name":"plasma metabolites","score":0.5839999914169312},{"id":"https://openalex.org/keywords/serum-metabolites","display_name":"serum metabolites","score":0.859000027179718},{"id":"https://openalex.org/keywords/nicotine-metabolites","display_name":"nicotine metabolites","score":0.8169999718666077},{"id":"https://openalex.org/keywords/smokers-versus-nonsmokers","display_name":"smokers versus non-smokers","score":0.7799999713897705},{"id":"https://openalex.org/keywords/quality-control-samples","display_name":"quality control samples","score":0.777999997138977},{"id":"https://openalex.org/keywords/uplc-q-tof-ms","display_name":"UPLC-Q-TOF-MS","score":0.8080000281333923},{"id":"https://openalex.org/keywords/metabolic-phenotypes","display_name":"metabolic phenotypes","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.892067551612854},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4970290958881378},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44067680835723877},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.42634817957878113},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3259120285511017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1975664496421814}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015588","descriptor_name":"Observer Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062789","descriptor_name":"Tobacco Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1021/pr3007705","doi":"https://doi.org/10.1021/pr3007705","is_oa":true,"landing_page_url":"https://doi.org/10.1021/pr3007705","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/pr3007705?ref=article_openPDF","source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2578492","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3579455","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3579455","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3579455","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Proteome Res","raw_type":"Text"},{"id":"pmid:23240883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23240883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.797.4392","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.797.4392","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b2/74/pr3007705.PMC3579455.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1021/pr3007705","doi":"https://doi.org/10.1021/pr3007705","is_oa":true,"landing_page_url":"https://doi.org/10.1021/pr3007705","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/pr3007705?ref=article_openPDF","source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1034282553","display_name":"LABORATORY ASSESSMENT OF TOBACCO USE BEHAVIOR AND EXPOSURE TO TOXINS AMONG USERS","funder_award_id":"n01pc64402-4-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1719657011","display_name":null,"funder_award_id":"1R01 CA114377\u221201A2","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2332454928","display_name":null,"funder_award_id":"NCI N01-PC-64402","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5033279109","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR013297","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6754719614","display_name":"Laboratory based Evaluation of Tobacco Harm Reduction","funder_award_id":"R01CA114377","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G795411066","display_name":null,"funder_award_id":"N01 PC064402","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090798613.pdf","grobid_xml":"https://content.openalex.org/works/W2090798613.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1150927","https://openalex.org/W187554151","https://openalex.org/W560473619","https://openalex.org/W1509926796","https://openalex.org/W1521998039","https://openalex.org/W1541776008","https://openalex.org/W1867313983","https://openalex.org/W1897950719","https://openalex.org/W1964010911","https://openalex.org/W1964646889","https://openalex.org/W1965501701","https://openalex.org/W1968430975","https://openalex.org/W1969889522","https://openalex.org/W1971606140","https://openalex.org/W1982185581","https://openalex.org/W1984971566","https://openalex.org/W1988151751","https://openalex.org/W1994397833","https://openalex.org/W1997828131","https://openalex.org/W2001966671","https://openalex.org/W2003799884","https://openalex.org/W2004301401","https://openalex.org/W2008602777","https://openalex.org/W2017076975","https://openalex.org/W2018153895","https://openalex.org/W2022071572","https://openalex.org/W2023663582","https://openalex.org/W2026814210","https://openalex.org/W2028240481","https://openalex.org/W2030097349","https://openalex.org/W2030471578","https://openalex.org/W2032555174","https://openalex.org/W2043987813","https://openalex.org/W2051180998","https://openalex.org/W2061417688","https://openalex.org/W2061543580","https://openalex.org/W2067461842","https://openalex.org/W2069936863","https://openalex.org/W2071534982","https://openalex.org/W2079590996","https://openalex.org/W2080130381","https://openalex.org/W2083210511","https://openalex.org/W2084415324","https://openalex.org/W2087354802","https://openalex.org/W2088716662","https://openalex.org/W2096576371","https://openalex.org/W2101324933","https://openalex.org/W2103021214","https://openalex.org/W2106017862","https://openalex.org/W2107363389","https://openalex.org/W2111100167","https://openalex.org/W2114094271","https://openalex.org/W2124054636","https://openalex.org/W2130452710","https://openalex.org/W2131219362","https://openalex.org/W2133895954","https://openalex.org/W2135170450","https://openalex.org/W2135977165","https://openalex.org/W2154999108","https://openalex.org/W2155897723","https://openalex.org/W2156613862","https://openalex.org/W2159124202","https://openalex.org/W2228687373","https://openalex.org/W2329966122","https://openalex.org/W2735168990","https://openalex.org/W2971034932","https://openalex.org/W2990238889","https://openalex.org/W4233763100","https://openalex.org/W4250187775","https://openalex.org/W4253083207","https://openalex.org/W4254811157","https://openalex.org/W4299128497"],"related_works":["https://openalex.org/W2473634482","https://openalex.org/W2747926459","https://openalex.org/W2563781570","https://openalex.org/W2040952485","https://openalex.org/W2062322586","https://openalex.org/W1985498624","https://openalex.org/W2333142264","https://openalex.org/W2065127110","https://openalex.org/W7024173068","https://openalex.org/W3107432940"],"abstract_inverted_index":{"Metabolomics":[0],"is":[1,125],"likely":[2],"an":[3,44,55],"ideal":[4],"tool":[5],"to":[6,83,104,154,183,191],"assess":[7,23],"tobacco":[8],"smoke":[9,16,92,193],"exposure":[10,19,194],"and":[11,20,25,100,115,149,187,195],"the":[12,36,85,132,139,155,181],"impact":[13],"of":[14,27,38,46,57,76,87,97,131,157],"cigarette":[15,192],"on":[17],"human":[18],"health.":[21],"To":[22],"reproducibility":[24],"feasibility":[26,86],"this":[28],"by":[29,178],"UPLC-QTOF-MS,":[30],"three":[31],"experiments":[32],"were":[33,176],"designed":[34],"for":[35],"assessment":[37],"smokers'":[39],"blood.":[40],"Experiment":[41,52,94],"I":[42],"was":[43,54,112,163],"analysis":[45,56],"8":[47,50],"smokers":[48,99,168],"with":[49],"replicates.":[51],"II":[53],"62":[58],"pooled":[59],"quality":[60],"control":[61],"(QC)":[62],"samples":[63,78,137],"from":[64,79,169,173],"7":[65],"nonsmokers'":[66,102],"plasma":[67],"placed":[68],"as":[69,160],"every":[70],"tenth":[71],"sample":[72,116],"among":[73],"a":[74,164],"study":[75,89],"613":[77],"160":[80],"smokers.":[81],"Finally,":[82,151],"examine":[84],"metabolomic":[88],"in":[90,107,119,138,152],"assessing":[91,135],"exposure,":[93],"III":[95],"consisted":[96],"9":[98],"10":[101],"serum":[103],"evaluate":[105],"differences":[106],"their":[108],"global":[109],"metabolome.":[110],"There":[111],"minimal":[113],"measurement":[114],"preparation":[117],"variation":[118],"all":[120],"experiments,":[121],"although":[122],"some":[123],"caution":[124],"needed":[126],"when":[127],"analyzing":[128],"specific":[129],"parts":[130],"chromatogram.":[133],"When":[134],"QC":[136,143],"large":[140],"scale":[141],"study,":[142],"clustering":[144],"indicated":[145],"high":[146],"stability,":[147],"reproducibility,":[148],"consistency.":[150],"addition":[153],"identification":[156],"nicotine":[158],"metabolites":[159,189],"expected,":[161],"there":[162],"characteristic":[165],"profile":[166],"distinguishing":[167],"nonsmokers.":[170],"Metabolites":[171],"selected":[172],"putative":[174],"identifications":[175],"verified":[177],"MS/MS,":[179],"showing":[180],"potential":[182],"identify":[184],"metabolic":[185],"phenotypes":[186],"new":[188],"relating":[190],"toxicity.":[196]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
