{"id":"https://openalex.org/W2090773236","doi":"https://doi.org/10.1097/01.pai.0000213107.20355.d8","title":"Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation","display_name":"Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation","publication_year":2007,"publication_date":"2007-05-22","ids":{"openalex":"https://openalex.org/W2090773236","doi":"https://doi.org/10.1097/01.pai.0000213107.20355.d8","mag":"2090773236","pmid":"https://pubmed.ncbi.nlm.nih.gov/17525630"},"language":"en","primary_location":{"id":"doi:10.1097/01.pai.0000213107.20355.d8","doi":"https://doi.org/10.1097/01.pai.0000213107.20355.d8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pai.0000213107.20355.d8","pdf_url":null,"source":{"id":"https://openalex.org/S42732013","display_name":"Applied immunohistochemistry & molecular morphology","issn_l":"1533-4058","issn":["1533-4058","1541-2016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Immunohistochemistry &amp; Molecular Morphology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044777574","display_name":"Xueying Shi","orcid":"https://orcid.org/0000-0003-0384-560X","observed_orcids":["https://orcid.org/0000-0003-0384-560X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueying Shi","raw_affiliation_strings":["Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China. zhsh6812@yahoo.com.cn","Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China 100083","The abstract has been presented in the First Annual Scientific Meeting of Asia-Pacific Society for Molecular Immunohistology on August 2005, Beijing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China. zhsh6812@yahoo.com.cn","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China 100083","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"The abstract has been presented in the First Annual Scientific Meeting of Asia-Pacific Society for Molecular Immunohistology on August 2005, Beijing","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005035441","display_name":"Encong Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Encong Gong","raw_affiliation_strings":["Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China 100083","The abstract has been presented in the First Annual Scientific Meeting of Asia-Pacific Society for Molecular Immunohistology on August 2005, Beijing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China 100083","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"The abstract has been presented in the First Annual Scientific Meeting of Asia-Pacific Society for Molecular Immunohistology on August 2005, Beijing","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107994281","display_name":"Xiaopan Wu","orcid":"https://orcid.org/0000-0002-3839-4522","observed_orcids":["https://orcid.org/0000-0002-3839-4522"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaopan Wu","raw_affiliation_strings":["Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China 100083","The abstract has been presented in the First Annual Scientific Meeting of Asia-Pacific Society for Molecular Immunohistology on August 2005, Beijing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of basic Medical Sciences, Peking University, Beijing, China 100083","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"The abstract has been presented in the First Annual Scientific Meeting of Asia-Pacific Society for Molecular Immunohistology on August 2005, Beijing","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":null,"apc_paid":null,"fwci":0.578,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67986021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"15","issue":"2","first_page":"175","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-methylacyl-coa-racemase","display_name":"AMACR","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.765999972820282},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6179999709129333},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7213333249092102},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6531487107276917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6184899806976318},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5949797034263611},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.545708954334259},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5381053686141968},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5109931230545044},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.493314653635025},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.46011975407600403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27927708625793457},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19064658880233765}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019998","descriptor_name":"Racemases and Epimerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019998","descriptor_name":"Racemases and Epimerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.pai.0000213107.20355.d8","doi":"https://doi.org/10.1097/01.pai.0000213107.20355.d8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pai.0000213107.20355.d8","pdf_url":null,"source":{"id":"https://openalex.org/S42732013","display_name":"Applied immunohistochemistry & molecular morphology","issn_l":"1533-4058","issn":["1533-4058","1541-2016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Immunohistochemistry &amp; Molecular Morphology","raw_type":"journal-article"},{"id":"pmid:17525630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17525630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied immunohistochemistry & molecular morphology : AIMM","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1564446762","https://openalex.org/W1930548389","https://openalex.org/W1963527363","https://openalex.org/W1966056172","https://openalex.org/W1967548067","https://openalex.org/W1991192859","https://openalex.org/W1993786011","https://openalex.org/W2006473247","https://openalex.org/W2007483540","https://openalex.org/W2023370107","https://openalex.org/W2025903599","https://openalex.org/W2035936829","https://openalex.org/W2044392113","https://openalex.org/W2060768796","https://openalex.org/W2067120288","https://openalex.org/W2090406571","https://openalex.org/W2095128237","https://openalex.org/W2110188341","https://openalex.org/W2116575688","https://openalex.org/W2121425345","https://openalex.org/W2133763650","https://openalex.org/W2139154860","https://openalex.org/W2139797259","https://openalex.org/W2159257506","https://openalex.org/W2164594843","https://openalex.org/W2167370693","https://openalex.org/W2167474785","https://openalex.org/W2264698944","https://openalex.org/W2281407457","https://openalex.org/W2376539910","https://openalex.org/W2406089649","https://openalex.org/W2416978655","https://openalex.org/W6695175355","https://openalex.org/W6717975514"],"related_works":["https://openalex.org/W2095907870","https://openalex.org/W3007393561","https://openalex.org/W2071798080","https://openalex.org/W2617587148","https://openalex.org/W2995526723","https://openalex.org/W2110188341","https://openalex.org/W2390880480","https://openalex.org/W2473909306","https://openalex.org/W2510783509","https://openalex.org/W2139154860"],"abstract_inverted_index":{"Alpha-methylacyl-CoA":[0],"racemase":[1],"(AMACR)/P504S":[2],"is":[3,15,268],"an":[4],"enzyme":[5],"involved":[6],"in":[7,35,42,149,160,172,183,197,212,221,237,266],"the":[8,31,61,65,143,208,259,262],"metabolism":[9],"of":[10,19,33,38,64,73,81,92,112,117,128,147,181,190,199,210,219,264],"branched-chain":[11],"fatty":[12],"acids.":[13],"Little":[14],"known":[16],"about":[17],"correlation":[18],"AMACR":[20,34,182,236,251,265],"expression":[21,32,148,211,220,252,263],"with":[22,46,83,136,270],"colorectal":[23],"carcinoma":[24],"(CRC)":[25],"differentiation":[26,63],"and":[27,41,76,94,115,132,151,156,164,225,231,253],"prognosis.":[28],"We":[29],"investigated":[30],"106":[36],"cases":[37,53,72,91,127],"primary":[39,66,150,184,224],"CRC,":[40],"47":[43],"lymph":[44,84,120,137],"nodes":[45],"metastatic":[47,152,202,226],"CRC":[48,267],"by":[49],"immunohistochemical":[50],"analysis.":[51],"These":[52],"were":[54,154,228],"divided":[55],"into":[56],"3":[57],"groups":[58,161],"according":[59],"to":[60,100,188,207,241],"histologic":[62],"tumors.":[67],"group":[68,87,101,123,173,177,191,200,213,222],"A":[69,162,223],"included":[70,89,125],"50":[71],"histologically":[74,98],"well":[75,93],"moderately":[77,95],"differentiated":[78,96,130],"CRCs,":[79,97],"20":[80],"these":[82,104,118],"node":[85,121,138],"metastasis;":[86,122],"B":[88,165,201],"23":[90],"similar":[99,187,206,229],"A,":[102,192],"except":[103],"tumors":[105,185,227],"had":[106,119],"small":[107],"foci":[108],"(less":[109],"than":[110,170],"20%)":[111],"high-grade":[113],"carcinoma,":[114,134],"10":[116],"C":[124,174,214],"33":[126],"poorly":[129],"adenocarcinoma":[131],"undifferentiated":[133],"17":[135],"metastasis.":[139],"The":[140],"results":[141],"showed":[142],"overall":[144,254],"positive":[145],"rates":[146,218],"CRCs":[153],"59.4%":[155],"46.8%,":[157],"respectively.":[158],"Expression":[159],"(76.0%)":[163],"(69.6%)":[166],"was":[167,186,194,205,243,248],"much":[168],"higher":[169],"that":[171,189,261],"(27.3%).":[175],"In":[176,216],"B,":[178],"although":[179],"overexpression":[180],"it":[193],"only":[195],"seen":[196],"30.0%":[198],"tumors,":[203],"which":[204],"rate":[209],"(23.5%).":[215],"contrast,":[217],"(80.0%":[230],"75.0%).":[232],"Positive":[233],"staining":[234],"for":[235],"benign":[238],"epithelium":[239],"adjacent":[240],"tumor":[242,271],"rare":[244],"(<2%).":[245],"No":[246],"relation":[247],"found":[249],"between":[250],"survival.":[255],"Our":[256],"findings":[257],"support":[258],"view":[260],"correlated":[269],"differentiation.":[272]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}