{"id":"https://openalex.org/W2090739735","doi":"https://doi.org/10.2165/00002512-199101060-00006","title":"Physiological Changes Due to Age","display_name":"Physiological Changes Due to Age","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2090739735","doi":"https://doi.org/10.2165/00002512-199101060-00006","mag":"2090739735","pmid":"https://pubmed.ncbi.nlm.nih.gov/1794033"},"language":"en","primary_location":{"id":"doi:10.2165/00002512-199101060-00006","doi":"https://doi.org/10.2165/00002512-199101060-00006","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00002512-199101060-00006","pdf_url":null,"source":{"id":"https://openalex.org/S37256505","display_name":"Drugs & Aging","issn_l":"1170-229X","issn":["1170-229X","1179-1969"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs &amp; Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028419147","display_name":"Iwona Stolarek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. Stolarek","raw_affiliation_strings":["Department of Geriatric Medicine, Stobhill General Hospital, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Stobhill General Hospital, Glasgow, Scotland","institution_ids":["https://openalex.org/I2802797558"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P.J.W. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050120","display_name":"Southern General Hospital","ror":"https://ror.org/04wvkky61","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802050120","https://openalex.org/I4210158502"]},{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.J.W. Scott","raw_affiliation_strings":["Department of Geriatric Medicine, Stobhill General Hospital, Glasgow, Scotland","University Department of Geriatric Medicine, Southern General Hospital, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Stobhill General Hospital, Glasgow, Scotland","institution_ids":["https://openalex.org/I2802797558"]},{"raw_affiliation_string":"University Department of Geriatric Medicine, Southern General Hospital, Glasgow, Scotland","institution_ids":["https://openalex.org/I2802050120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113953113","display_name":"F. I. Caird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050120","display_name":"Southern General Hospital","ror":"https://ror.org/04wvkky61","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802050120","https://openalex.org/I4210158502"]},{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F.I. Caird","raw_affiliation_strings":["Department of Geriatric Medicine, Stobhill General Hospital, Glasgow, Scotland","University Department of Geriatric Medicine, Southern General Hospital, Glasgow, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Stobhill General Hospital, Glasgow, Scotland","institution_ids":["https://openalex.org/I2802797558"]},{"raw_affiliation_string":"University Department of Geriatric Medicine, Southern General Hospital, Glasgow, Scotland","institution_ids":["https://openalex.org/I2802050120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.7071,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.72887669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"6","first_page":"467","last_page":"476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.4828999936580658,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.4828999936580658,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.17749999463558197,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.10939999669790268,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cardiovascular-physiology","display_name":"cardiovascular physiology","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cardiovascular-pharmacology","display_name":"cardiovascular pharmacology","score":0.7360000014305115},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6589999794960022},{"id":"https://openalex.org/keywords/maximum-heart-rate","display_name":"maximal heart rate","score":0.7680000066757202},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.9470000267028809},{"id":"https://openalex.org/keywords/plasma-norepinephrine","display_name":"plasma norepinephrine","score":0.878000020980835},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.6740000247955322},{"id":"https://openalex.org/keywords/drug-elimination","display_name":"drug elimination","score":0.859000027179718},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.6880000233650208},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.849020779132843},{"id":"https://openalex.org/C79752029","wikidata":"https://www.wikidata.org/wiki/Q808732","display_name":"Baroreceptor","level":4,"score":0.6243680119514465},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.602556586265564},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5626977682113647},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5100947022438049},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49325650930404663},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47736573219299316},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.47323712706565857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4658803343772888},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.4539484977722168},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4309699237346649},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4298970103263855},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.41451531648635864},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.41007000207901},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2940039038658142},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2274520993232727},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/00002512-199101060-00006","doi":"https://doi.org/10.2165/00002512-199101060-00006","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00002512-199101060-00006","pdf_url":null,"source":{"id":"https://openalex.org/S37256505","display_name":"Drugs & Aging","issn_l":"1170-229X","issn":["1170-229X","1179-1969"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs &amp; Aging","raw_type":"journal-article"},{"id":"pmid:1794033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1794033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs & aging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W150877756","https://openalex.org/W606433516","https://openalex.org/W1892866931","https://openalex.org/W1959222363","https://openalex.org/W1963698801","https://openalex.org/W1964061197","https://openalex.org/W1968493849","https://openalex.org/W1968861010","https://openalex.org/W1969339562","https://openalex.org/W1971244664","https://openalex.org/W1975037618","https://openalex.org/W1977804080","https://openalex.org/W1979634507","https://openalex.org/W1983348140","https://openalex.org/W1987492961","https://openalex.org/W1987531347","https://openalex.org/W1987591466","https://openalex.org/W1988625353","https://openalex.org/W1989463301","https://openalex.org/W1999153032","https://openalex.org/W1999600985","https://openalex.org/W2001428635","https://openalex.org/W2004977704","https://openalex.org/W2006793498","https://openalex.org/W2008271145","https://openalex.org/W2008460170","https://openalex.org/W2011241344","https://openalex.org/W2012464391","https://openalex.org/W2013854344","https://openalex.org/W2025266169","https://openalex.org/W2033521365","https://openalex.org/W2034842322","https://openalex.org/W2039856801","https://openalex.org/W2044455629","https://openalex.org/W2046309221","https://openalex.org/W2047332924","https://openalex.org/W2051017744","https://openalex.org/W2051386984","https://openalex.org/W2056396767","https://openalex.org/W2057426066","https://openalex.org/W2059122113","https://openalex.org/W2061179388","https://openalex.org/W2062226497","https://openalex.org/W2063284592","https://openalex.org/W2073274896","https://openalex.org/W2076915743","https://openalex.org/W2078865702","https://openalex.org/W2083498095","https://openalex.org/W2084535212","https://openalex.org/W2084680549","https://openalex.org/W2094109678","https://openalex.org/W2096026912","https://openalex.org/W2105384939","https://openalex.org/W2106599269","https://openalex.org/W2108094183","https://openalex.org/W2110344705","https://openalex.org/W2117773619","https://openalex.org/W2143648744","https://openalex.org/W2146766834","https://openalex.org/W2147212602","https://openalex.org/W2153583116","https://openalex.org/W2155972258","https://openalex.org/W2160542890","https://openalex.org/W2161816921","https://openalex.org/W2164088115","https://openalex.org/W2176077554","https://openalex.org/W2285394125","https://openalex.org/W2315873287","https://openalex.org/W2320558234","https://openalex.org/W2327384329","https://openalex.org/W2401884674","https://openalex.org/W2402272431","https://openalex.org/W2408185311","https://openalex.org/W2408959636","https://openalex.org/W2410369374","https://openalex.org/W2412256995","https://openalex.org/W2412859516","https://openalex.org/W2414427325","https://openalex.org/W2414660958","https://openalex.org/W2414715525","https://openalex.org/W2419798841","https://openalex.org/W2428291947","https://openalex.org/W2465985015","https://openalex.org/W4234657925","https://openalex.org/W4293003451","https://openalex.org/W4298155037"],"related_works":["https://openalex.org/W2069534028","https://openalex.org/W2063348531","https://openalex.org/W1529956944","https://openalex.org/W2166975456","https://openalex.org/W2168134541","https://openalex.org/W1992415682","https://openalex.org/W2079075541","https://openalex.org/W4205742800","https://openalex.org/W2323656486","https://openalex.org/W2404231807"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
